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Entry version 55 (02 Jun 2021)
Sequence version 2 (09 Jan 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

TOPBP1

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOPBP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri13616 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002280 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMODG00000011537, Expressed in hindlimb bud and 22 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
13616.ENSMODP00000014442

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini101 – 174BRCTInterPro annotationAdd BLAST74
Domaini195 – 284BRCTInterPro annotationAdd BLAST90
Domaini355 – 445BRCTInterPro annotationAdd BLAST91
Domaini537 – 622BRCTInterPro annotationAdd BLAST86
Domaini631 – 728BRCTInterPro annotationAdd BLAST98
Domaini889 – 980BRCTInterPro annotationAdd BLAST92
Domaini1276 – 1341BRCTInterPro annotationAdd BLAST66
Domaini1379 – 1476BRCTInterPro annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni286 – 310DisorderedSequence analysisAdd BLAST25
Regioni464 – 486DisorderedSequence analysisAdd BLAST23
Regioni750 – 770DisorderedSequence analysisAdd BLAST21
Regioni1076 – 1104DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi290 – 310Polar residuesSequence analysisAdd BLAST21
Compositional biasi472 – 486Basic and acidic residuesSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1929, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157001

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004165_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6QWV3

Identification of Orthologs from Complete Genome Data

More...
OMAi
ACTHLLC

Database of Orthologous Groups

More...
OrthoDBi
557169at2759

TreeFam database of animal gene trees

More...
TreeFami
TF326403

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10190, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00533, BRCT, 3 hits
PF12738, PTCB-BRCT, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00292, BRCT, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52113, SSF52113, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50172, BRCT, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F6QWV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSENDREPYY VKFVKAQANS KFFFTALGSM KEFQSEEYLQ TITEEEALNI
60 70 80 90 100
KKNDRSLYIC DPFSGIVFDH LKKLGCRIVG PQVVIFCMQQ QRCVPKAEYP
110 120 130 140 150
VYNMIMADVT ISCTSLDKET RKEVHKYVQM MGGRVCRDLS ISVTHLIAGE
160 170 180 190 200
VGSKKYLVAA NLGKPIMLPS WVKELWKKSQ EKCLTQFTDI NMEDFKCPIF
210 220 230 240 250
FGCTICVTGL CSVDRRAVQR LTVEHGGQYM GQLKMNECTH LIVQEPKGPK
260 270 280 290 300
YECAKRWNVH CVTIQWFFHS IEKNFCQDEA KYKTEPRSEA KSVPGTSTPT
310 320 330 340 350
GQNNEASGRT LSDVSHISNI NSSCINESTH NSIMNNKLGS LLENLQNLDI
360 370 380 390 400
SAFQAPEDLL DGCRIYLCGF SGRKLDKLRR LINCGGGVRF NQLNEDVTHV
410 420 430 440 450
IVGDYDDELK QFWTKSTHRP HVVGAKWLLE CFSKGYLLSE EPYIHLNYQP
460 470 480 490 500
VEITVSDQPA MKSTLSKRNN SFSKKESVDT EKHQQTDEDL LSQYMNMLVD
510 520 530 540 550
EGEKSGTGIF IDSSDITVQA ENQSSLSHNS LPEISTNIEG LFSRKKFLVV
560 570 580 590 600
GFSEEDESCI ADAIKENAGK ILPLQSRTIS DYAVVPLLGC EVESTVGEVV
610 620 630 640 650
TNTWLITCIE QQKLFDPESN PLFTPIPVLE ASNSPLENCV LSFSQFIGAE
660 670 680 690 700
KDSLVYLASL LGARVQEFFV RKDNAKNDMF ASTHLIVKQP DGSKYQAAQK
710 720 730 740 750
WGLPAVTMAW ILETAKLGRR ADECKFMVGN LPKQEESFET QLTVNKTYSD
760 770 780 790 800
TSENSSMVLE PERRPPVTPL DVNRFQSKTF HTVISQHSKK CSIPPIEAQP
810 820 830 840 850
LQKEPSLHLD TPSKFLSKDK LFKPSFDVKD ALAALETPLG PSQRSRRMST
860 870 880 890 900
PLSEVIGRNL KHALANSTRH TVALTASPVL KDAQSEKEED PKPLHNVVIC
910 920 930 940 950
VSKKLSKKQS ELNTIAASLG AEYRWSFDET VTHFIYQGRP NDTNREYKSI
960 970 980 990 1000
KERGIHIVSE HWLLESARVQ RRLPESLYPH TYNPKMSLDI SAVQDSRVCP
1010 1020 1030 1040 1050
NQSPSTGKMA KDDDEPLLHL SLEGNDEDIT IDQKHVANTN GEIPNIPKGA
1060 1070 1080 1090 1100
LTQTLEMRKS FQKQLQEIMS ATSTVKLQGQ RNSLSRNGCD SSSSTPDNTW
1110 1120 1130 1140 1150
SARSGRSRVL EALRQSRQAI ADVNIEPSQS EQIIWDDPTA REERARLASN
1160 1170 1180 1190 1200
FQWPICPTQY PDLQTSIKDL EDSPFQESLH DSTVAENAVC DPGDTCVTKT
1210 1220 1230 1240 1250
PKEPVCEDLE ATIKDSHLIP TPQAPSIAFP LANPPVAPHP KEKTVQAEET
1260 1270 1280 1290 1300
HEELEKQYRF QLSSLNPQER IDYCHLIEEL GGLVLEKQCF DPSCTHIVVG
1310 1320 1330 1340 1350
HPLRNEKYLA SMAAGKWVLH RSYLEACRAA GHFVQEEEYE WGSNSILDAL
1360 1370 1380 1390 1400
TGITVQQRKL ALAAMRWRKR IQKKQEEGIV EGAFSGWKVI LNVDQSREAG
1410 1420 1430 1440 1450
FRRLLQSGGA KVLPGHSVPL FKEATHLFAD FNKLKPDDSR VNIGEAVAHK
1460 1470 1480 1490 1500
VNCLKPEYIA DYLMQESPPS LECYSLPEAV SFLQNNKETA AGLSQKRKTS
1510
TEINKFKRPR IY
Length:1,512
Mass (Da):170,153
Last modified:January 9, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC899881071A4DD1C
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_003342122.1, XM_003342074.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMODT00000014708; ENSMODP00000014442; ENSMODG00000011537

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100030030

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mdo:100030030

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_003342122.1, XM_003342074.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi13616.ENSMODP00000014442

Genome annotation databases

EnsembliENSMODT00000014708; ENSMODP00000014442; ENSMODG00000011537
GeneIDi100030030
KEGGimdo:100030030

Phylogenomic databases

eggNOGiKOG1929, Eukaryota
GeneTreeiENSGT00940000157001
HOGENOMiCLU_004165_1_0_1
InParanoidiF6QWV3
OMAiACTHLLC
OrthoDBi557169at2759
TreeFamiTF326403

Gene expression databases

BgeeiENSMODG00000011537, Expressed in hindlimb bud and 22 other tissues

Family and domain databases

Gene3Di3.40.50.10190, 9 hits
InterProiView protein in InterPro
IPR001357, BRCT_dom
IPR036420, BRCT_dom_sf
PfamiView protein in Pfam
PF00533, BRCT, 3 hits
PF12738, PTCB-BRCT, 3 hits
SMARTiView protein in SMART
SM00292, BRCT, 9 hits
SUPFAMiSSF52113, SSF52113, 6 hits
PROSITEiView protein in PROSITE
PS50172, BRCT, 8 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6QWV3_MONDO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6QWV3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: January 9, 2013
Last modified: June 2, 2021
This is version 55 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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