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Protein
Submitted name:

Actin, aortic smooth muscle

Gene

ACTA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiF6QUT6

Names & Taxonomyi

Protein namesi
Submitted name:
Actin, aortic smooth muscleImported
Gene namesi
Name:ACTA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107796.12
HGNCiHGNC:130 ACTA2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000107796

PTM / Processingi

Proteomic databases

PeptideAtlasiF6QUT6
PRIDEiF6QUT6

Expressioni

Gene expression databases

BgeeiENSG00000107796 Expressed in 236 organ(s), highest expression level in thoracic aorta
ExpressionAtlasiF6QUT6 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF6QUT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00930000150927

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F6QUT6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCEEEDSTAL VCDNGSGLCK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG
60 70 80 90 100
QKDSYVGDEA QSKRGILTLK YPIEHGIITN WDDMEKIWHH SFYNELRVAP
110 120 130 140 150
EEHPTLLTEA PLNPKANREK MTQIMFETFN VPAMYVAIQA VLSLYASGRT

T
Length:151
Mass (Da):16,759
Last modified:February 22, 2012 - v1
Checksum:i2C5852212D6163DB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P62736ACTA_HUMAN
Actin, aortic smooth muscle
ACTA2 ACTSA, ACTVS, GIG46
377Annotation score:
F6UVQ4F6UVQ4_HUMAN
Actin, aortic smooth muscle
ACTA2
151Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei151Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157394 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000415557; ENSP00000396730; ENSG00000107796

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157394 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliF6QUT6
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiF6QUT6
PRIDEiF6QUT6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000415557; ENSP00000396730; ENSG00000107796

Organism-specific databases

EuPathDBiHostDB:ENSG00000107796.12
HGNCiHGNC:130 ACTA2
OpenTargetsiENSG00000107796
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00930000150927

Enzyme and pathway databases

SignaLinkiF6QUT6

Miscellaneous databases

ChiTaRSiACTA2 human

Gene expression databases

BgeeiENSG00000107796 Expressed in 236 organ(s), highest expression level in thoracic aorta
ExpressionAtlasiF6QUT6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF6QUT6_HUMAN
AccessioniPrimary (citable) accession number: F6QUT6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 7, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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