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Protein

Heparan-sulfate 6-O-sulfotransferase

Gene

HS6ST2

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.UniRule annotation

Catalytic activityi

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Heparan-sulfate 6-O-sulfotransferaseUniRule annotation (EC:2.8.2.-UniRule annotation)
Gene namesi
Name:HS6ST2Imported
OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
Taxonomic identifieri13616 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
Proteomesi
  • UP000002280 Componenti: Chromosome X

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Expressioni

Gene expression databases

BgeeiENSMODG00000015297

Interactioni

Protein-protein interaction databases

STRINGi13616.ENSMODP00000019103

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfotransferase 6 family.UniRule annotation

Keywords - Domaini

Signal-anchorUniRule annotation, Transmembrane

Phylogenomic databases

eggNOGiKOG3955 Eukaryota
ENOG410XSW4 LUCA
GeneTreeiENSGT00390000013468
InParanoidiF6QDG7
KOiK08102
OMAiNYYYITI
OrthoDBiEOG091G08UD
TreeFamiTF312835

Family and domain databases

InterProiView protein in InterPro
IPR010635 Heparan_SO4-6-sulfoTrfase
IPR027417 P-loop_NTPase
IPR005331 Sulfotransferase
PANTHERiPTHR12812 PTHR12812, 1 hit
PfamiView protein in Pfam
PF03567 Sulfotransfer_2, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

Sequencei

Sequence statusi: Complete.

F6QDG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDKSNKLLL ALVMLFLFAV IVVQYVCPGT ECQLLRLQAF ASSHADPYRT
60 70 80 90 100
EDESPPRFVA RLNFTDAELL RKVDFNIKGD DLIVFLHIQK TGGTTFGRHL
110 120 130 140 150
VRNIQLEQPC ECKAGQKKCT CHRPGKRETW LFSRFSTGWS CGLHADWTEL
160 170 180 190 200
TNCVPSIVDS KKEAKLRPTS CCKSKKAHCV CRDPKGAYQR RGTKKRRNFY
210 220 230 240 250
YITILRDPVS RYLSEWRHVQ RGATWKASLH VCDGRSPTIE ELPSCYAGDD
260 270 280 290 300
WSGCSLKEFM DCPYNLANNR QVRMLSDLSL VGCYNLSVMP EEQRNKVLLD
310 320 330 340 350
SAKENLKCMA FFGLTEFQRK TQYLFEKTFN MNFISPFTQY NNTRASSVEI
360 370 380 390 400
DQQTQKRIEA LNFLDMELYE YAKDLFLQRY QFTRQKDHQE ARRKRQERKI
410 420
LKTRHVHKRD QTDNATADYV EDVEKWR
Length:427
Mass (Da):49,953
Last modified:January 9, 2013 - v2
Checksum:i72F17032D0FBA0EE
GO

Sequence databases

RefSeqiXP_007507262.1, XM_007507200.2

Genome annotation databases

EnsembliENSMODT00000019448; ENSMODP00000019103; ENSMODG00000015297
GeneIDi100013802
KEGGimdo:100013802

Similar proteinsi

Entry informationi

Entry nameiF6QDG7_MONDO
AccessioniPrimary (citable) accession number: F6QDG7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: January 9, 2013
Last modified: July 18, 2018
This is version 41 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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