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Entry version 54 (11 Dec 2019)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Collagen type XV alpha 1 chain

Gene

COL15A1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen type XV alpha 1 chainImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL15A1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 25

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:16725 COL15A1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6Q978

PRoteomics IDEntifications database

More...
PRIDEi
F6Q978

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000021211 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 219LAM_G_DOMAINInterPro annotationAdd BLAST189
Domaini80 – 218LAM_G_DOMAINInterPro annotationAdd BLAST139

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni213 – 242DisorderedSequence analysisAdd BLAST30
Regioni257 – 324DisorderedSequence analysisAdd BLAST68
Regioni372 – 426DisorderedSequence analysisAdd BLAST55
Regioni534 – 791DisorderedSequence analysisAdd BLAST258
Regioni833 – 864DisorderedSequence analysisAdd BLAST32
Regioni876 – 910DisorderedSequence analysisAdd BLAST35
Regioni983 – 1120DisorderedSequence analysisAdd BLAST138

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi302 – 324PolarSequence analysisAdd BLAST23
Compositional biasi614 – 628Pro-richSequence analysisAdd BLAST15
Compositional biasi711 – 727Pro-richSequence analysisAdd BLAST17
Compositional biasi1069 – 1102Pro-richSequence analysisAdd BLAST34

Keywords - Domaini

CollagenSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3546 Eukaryota
ENOG410XQ04 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158302

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6Q978

TreeFam database of animal gene trees

More...
TreeFami
TF315821

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00247 Endostatin-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR039070 COL15A1
IPR008160 Collagen
IPR010515 Collagenase_NC10/endostatin
IPR013320 ConA-like_dom_sf
IPR016187 CTDL_fold
IPR001791 Laminin_G

The PANTHER Classification System

More...
PANTHERi
PTHR24023:SF912 PTHR24023:SF912, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01391 Collagen, 4 hits
PF06482 Endostatin, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00282 LamG, 1 hit
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF56436 SSF56436, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F6Q978-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVHTQEPVST HVKGGRELTT RTQRESASQG HLDLTELIGV PLPSSVSFVT
60 70 80 90 100
GYGGFPAYSF GPGANVGRPA RTLIPPTFFR DFAISVTVKP NSARGGVLFA
110 120 130 140 150
ITDAFQKVIY LGLRLSGAED GHQRVILYYT EPGSQVSHEA AAFLVPVMTH
160 170 180 190 200
RWNRFAVIVR GEEVSLLVDC EEHSPVPFQR SSQPLAFEPS AGIFVGNAGA
210 220 230 240 250
TGLERFTGSI QQLTVHPDPG TPEELCEAEE SSASGETSGL QETDGVAEIL
260 270 280 290 300
EAVTYTQAPS KEAQVEPIST PPTLSPPSED AELSGEPVPE GTLETTKLSE
310 320 330 340 350
PVPEGTPETT NLSVIPHSSP EQGSGEIMND TLEGAQTVDG APITDVGSGD
360 370 380 390 400
GAILHVIEEG PHPEEGLATT AAAGEAEVPV STAEEAEASG VPTGGPTLST
410 420 430 440 450
FTEDPGERVT PGLDTEEGSA ATAAEEAEVP IGTAGEVEAD TVRTGGPTLS
460 470 480 490 500
TSTQDPGEGV TLGPISEESL TTAVAATEVA LSTFEEEEAS GVPTDGLVPL
510 520 530 540 550
TPTVPSEQVV PSGPGDEEDL AAATTEEPLT AAGAEETGGA LPEGPPLPIP
560 570 580 590 600
TVAPERGVTP GGAEEVLSGP PGTAEPAGPT VRAEAEGSGL AWGLDLGSGS
610 620 630 640 650
GSDDLVRSEE LLRGPPGPPG PPGSPGIPGK PGTDIFMGPP GSPGEDGAAG
660 670 680 690 700
EPGPPGPEGQ PGLDGASGLP GMKGEKGARG PNGSVGEKGD PGSRGLPGPP
710 720 730 740 750
GKNGQVGTPG VMGPPGPPGP PGPPGPGCAT GLGFEDTEGS GSIRLLHEPR
760 770 780 790 800
ISGPTASSGP KGEKGDQGPK GDRGMDGASI VGPPGPRGPP GRIEVLPSSL
810 820 830 840 850
INITHGFKNL SDIPELMGPP GPEGMPGLPG FPGPRGPKGD TGVPGFPGLK
860 870 880 890 900
GEQGEKGEPG TILTGDVPLE RLRGMKGEPG AHGAPGPMGP KGPPGHKGEF
910 920 930 940 950
GLPGRPGRPG LNGLKGAKGD RGLMMPGPPG LPGPPGPPGP PGAVINIKGA
960 970 980 990 1000
VFPIPIRPHC KTPVGTTHPG NSELITFHGV KGEKGSWGLP GSKGEKGDQG
1010 1020 1030 1040 1050
AQGPPGPPVD PAYLRHFLNS LKGENGDRGL KGEKGDSNGD FLVSGPPGLP
1060 1070 1080 1090 1100
GNPGLVGQKG ETVIGPQGPP GAPGLPGPPG FGRPGSPGPP GPPGPPGPPA
1110 1120 1130 1140 1150
ILGAAVALPG PPGPPGQPGL PGSRNLVTAF SSMDDMLQNA HLVIEGTFIY
1160 1170 1180 1190 1200
LKDSAEFFIR VRDGWKKLQL GELIPIPADS LPPPALSSNP HQPQVPLTSV
1210 1220 1230 1240 1250
SSVTYERPAL HLVALNTPFS GDLRADFQCF QQARAAGLLS TYRAFLSSHL
1260 1270 1280 1290 1300
QDLSTVVRKA ERYSLPIVNL KGQVLFNNWD SVFSGHGGQF NTHVPIYSFD
1310 1320 1330 1340 1350
GRDVMTDPSW PQKAVWHGSS PRGVRLVDKY CEAWRTADTA VTGLASPLST
1360 1370 1380
GKILDQKTYS CANRLIVLCI ENSFMTDARK
Length:1,380
Mass (Da):140,298
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DBFF53AA0E68564
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6Q947F6Q947_HORSE
Collagen type XV alpha 1 chain
COL15A1
1,388Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000022894; ENSECAP00000018942; ENSECAG00000021211

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF6Q978
PRIDEiF6Q978

Genome annotation databases

EnsembliENSECAT00000022894; ENSECAP00000018942; ENSECAG00000021211

Organism-specific databases

VGNCiVGNC:16725 COL15A1

Phylogenomic databases

eggNOGiKOG3546 Eukaryota
ENOG410XQ04 LUCA
GeneTreeiENSGT00940000158302
InParanoidiF6Q978
TreeFamiTF315821

Gene expression databases

BgeeiENSECAG00000021211 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

CDDicd00247 Endostatin-like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR039070 COL15A1
IPR008160 Collagen
IPR010515 Collagenase_NC10/endostatin
IPR013320 ConA-like_dom_sf
IPR016187 CTDL_fold
IPR001791 Laminin_G
PANTHERiPTHR24023:SF912 PTHR24023:SF912, 2 hits
PfamiView protein in Pfam
PF01391 Collagen, 4 hits
PF06482 Endostatin, 2 hits
SMARTiView protein in SMART
SM00282 LamG, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
SSF56436 SSF56436, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6Q978_HORSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6Q978
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: December 11, 2019
This is version 54 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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