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Entry version 64 (07 Oct 2020)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

LAMA3

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMA3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501879392021 – 1724Sequence analysisAdd BLAST1704

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi94 ↔ 103PROSITE-ProRule annotation
Disulfide bondi122 ↔ 134PROSITE-ProRule annotation
Disulfide bondi145 ↔ 154PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6Q8N4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000021277, Expressed in epithelium of bronchus and 19 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F6Q8N4, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 103TNFR-CysInterPro annotationAdd BLAST49
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati55 – 103TNFR-CysPROSITE-ProRule annotationAdd BLAST49
Domaini75 – 121Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini122 – 174Laminin EGF-likeInterPro annotationAdd BLAST53
Domaini779 – 980LAM_G_DOMAINInterPro annotationAdd BLAST202
Domaini987 – 1149LAM_G_DOMAINInterPro annotationAdd BLAST163
Domaini1156 – 1316LAM_G_DOMAINInterPro annotationAdd BLAST161
Domaini1377 – 1541LAM_G_DOMAINInterPro annotationAdd BLAST165
Domaini1548 – 1721LAM_G_DOMAINInterPro annotationAdd BLAST174

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1344 – 1378DisorderedSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili248 – 303Sequence analysisAdd BLAST56
Coiled coili311 – 331Sequence analysisAdd BLAST21
Coiled coili352 – 372Sequence analysisAdd BLAST21
Coiled coili410 – 437Sequence analysisAdd BLAST28
Coiled coili445 – 465Sequence analysisAdd BLAST21
Coiled coili487 – 524Sequence analysisAdd BLAST38
Coiled coili528 – 555Sequence analysisAdd BLAST28
Coiled coili568 – 588Sequence analysisAdd BLAST21
Coiled coili728 – 748Sequence analysisAdd BLAST21
Coiled coili752 – 772Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155638

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002814_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6Q8N4

TreeFam database of animal gene trees

More...
TreeFami
TF335359

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR009254, Laminin_aI
IPR010307, Laminin_dom_II
IPR002049, Laminin_EGF
IPR001791, Laminin_G
IPR001368, TNFR/NGFR_Cys_rich_reg

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053, Laminin_EGF, 2 hits
PF02210, Laminin_G_2, 5 hits
PF06008, Laminin_I, 1 hit
PF06009, Laminin_II, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00180, EGF_Lam, 2 hits
SM00282, LamG, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899, SSF49899, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01248, EGF_LAM_1, 1 hit
PS50027, EGF_LAM_2, 2 hits
PS50025, LAM_G_DOMAIN, 5 hits
PS50050, TNFR_NGFR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F6Q8N4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPAVRWSAG WLWIFGAALG QCLGYDSQQQ RVVFLQPPGQ SHLQASYSEF
60 70 80 90 100
KPSQGCSPGY YRDNKGLYTG RCVPCSCNGH SHRCQDGSGI CINCQHNTAG
110 120 130 140 150
NHCERCKEGH YRNAVQGSCM VCPCPHSNSF ATGCVVTGGN VKCSCKPGYT
160 170 180 190 200
GTQCERCAPG YFGNPQKFGG SCQPCNCNNN GHLGSCDPVT GDCINQEPKD
210 220 230 240 250
DGPGEECDDC DSCVMTLLND LATMEGELRL VKSQLQGLSA SASTLEHMRH
260 270 280 290 300
LETQTKDLRN QLLNYRSAIS NHGSKMDGLE KELSNLNHEF ETLQEKVQIN
310 320 330 340 350
SRKVQALPNN VDRTTQRAKE LDTKIKNVIR NVHILLKQQF SGTNGEGNNV
360 370 380 390 400
LLGDFSRELA EADRMMRELR SRNFGKQLKD AEDGKKNAQL LLNRIRSWLE
410 420 430 440 450
KHQVENSGLV KSIRDSLNEY EAKLTDLRAM LQEAATQAKQ AAGLNRENQK
460 470 480 490 500
TLESIKRQVK EMNSLQSDFN KYLATADASL LQTSAVLQLM RKSQEEYEKL
510 520 530 540 550
AASLNEAKHE LRDKVKELSK SSSKTSLVVA AEKHAQSLQE LAKQLEEIKR
560 570 580 590 600
NTSGDELVRC AVDAATAYEN ILNAIKAAED AADKATSASE SAHQTVIKEN
610 620 630 640 650
LPRKAKTLSS NSEKLLNEAK ITQKKLQQEI SPALNNLQQT LKIMTVQKGL
660 670 680 690 700
IDTNITTIRD DLRGIQRGDI DGMINSAKSI VRNANDITNE VLDGLTPIQT
710 720 730 740 750
DVERIKDTYG STQSEDFNKA LGDADNSVKK LTNKLPDLLS KIESINQQLL
760 770 780 790 800
PLGNISDNVD RIRELIQQAR DAANKVAVPM RFNGKSGVEV RLPNDLEDLK
810 820 830 840 850
GYTSLSLFLQ RPDSRENGGT NNMFVMYLGK KDASRDYIGM AVVDGQLTCV
860 870 880 890 900
YNLGEREAEL QVDQILTESE TQESVMDRVK FQRIYQFARL NYTKKATSSK
910 920 930 940 950
PEATQPHDMD SGNSNTLLNL DPENAVFYVG GYPPDFRLPS RLRFPPYKGC
960 970 980 990 1000
IELDDLNENV LSLYNFKKTF NLNTTEVEPC RRRKEESDKN YFEGTGYARI
1010 1020 1030 1040 1050
PTQPNAPLPI FVQTIQTTVD RGLLFFAENQ DHFISLDIED GSLLVRYKLN
1060 1070 1080 1090 1100
SESPEEKGIR VIINDGKDHS IQIRIGKAQK LMRISVARED IKINGEIFDF
1110 1120 1130 1140 1150
STYYLGGIPI SIRERFNIST PAFRGCMKNL KKTTGVVRLN DTVGVTKKCS
1160 1170 1180 1190 1200
EDWKLVRSAS FSRGGQMSFT NLDFPLPSLF QASFGFQTFQ PGGILLHHQT
1210 1220 1230 1240 1250
RTSSLQVTLE DGHIELSTTD SSSPIFKSPQ TYMDGLLHYV SVISDTSGLR
1260 1270 1280 1290 1300
LLIDDQPLKN NQRLQGFSGS QQSLRLGGSH FEGCISNVFV HRSSQSPAVL
1310 1320 1330 1340 1350
DLASKSTKRE VSLGGCSLNE PPFLMLLKGS TRFNTAKTFS INQPLQDTPV
1360 1370 1380 1390 1400
ASPRSKERWR DAQSCPSPPK AQASHGALRF GDSPTSHLLF TVPQELLKSR
1410 1420 1430 1440 1450
SRFAVDVQTT SSRGLMFYTG TRNSFMALYL SKGRLVFALG AEGKKLKLKS
1460 1470 1480 1490 1500
KEKFNDGKWH TVAFGQDGEK ARLVVDGLRA REGSWPRSFT VSLRVPVYLG
1510 1520 1530 1540 1550
SPPSEKSKSL PQSSFVGCLR NLQLDSKPLA TPSVSFGVSP CSHGSLEKGI
1560 1570 1580 1590 1600
YFSQEGGHII LANSVLLGPE FKLVFSIRPR SLTGILIHIG SQRGKHLCVY
1610 1620 1630 1640 1650
MEAGKVTASV DSEAGGILTS VTPKRSLCDG QWHRVAVTIK KHILHLELDT
1660 1670 1680 1690 1700
ENSYTAGQLP FPPASAREPL HIGGVPANLQ TLKLPVWKSF FGCVKNVQVN
1710 1720
HIPVPVTEAV EVQGTVSLNG CPDH
Length:1,724
Mass (Da):190,826
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i694D0AD77E8CB8A4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6ZCR0F6ZCR0_HORSE
Uncharacterized protein
LAMA3
3,274Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HXJ3A0A3Q2HXJ3_HORSE
Uncharacterized protein
LAMA3
3,331Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000022904; ENSECAP00000018951; ENSECAG00000021277

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF6Q8N4

Genome annotation databases

EnsembliENSECAT00000022904; ENSECAP00000018951; ENSECAG00000021277

Phylogenomic databases

GeneTreeiENSGT00940000155638
HOGENOMiCLU_002814_0_0_1
InParanoidiF6Q8N4
TreeFamiTF335359

Gene expression databases

BgeeiENSECAG00000021277, Expressed in epithelium of bronchus and 19 other tissues
ExpressionAtlasiF6Q8N4, baseline

Family and domain databases

InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR009254, Laminin_aI
IPR010307, Laminin_dom_II
IPR002049, Laminin_EGF
IPR001791, Laminin_G
IPR001368, TNFR/NGFR_Cys_rich_reg
PfamiView protein in Pfam
PF00053, Laminin_EGF, 2 hits
PF02210, Laminin_G_2, 5 hits
PF06008, Laminin_I, 1 hit
PF06009, Laminin_II, 1 hit
SMARTiView protein in SMART
SM00180, EGF_Lam, 2 hits
SM00282, LamG, 5 hits
SUPFAMiSSF49899, SSF49899, 5 hits
PROSITEiView protein in PROSITE
PS01248, EGF_LAM_1, 1 hit
PS50027, EGF_LAM_2, 2 hits
PS50025, LAM_G_DOMAIN, 5 hits
PS50050, TNFR_NGFR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6Q8N4_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6Q8N4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: October 7, 2020
This is version 64 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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