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UniProtKB - F6Q8N4 (F6Q8N4_HORSE)

Entry version 64 (07 Oct 2020)
Sequence version 2 (10 Apr 2019)
Previous versions | rss
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Protein
Submitted name:

Uncharacterized protein

Gene

LAMA3

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMA3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501879392021 – 1724Sequence analysisAdd BLAST1704

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi94 ↔ 103PROSITE-ProRule annotation
Disulfide bondi122 ↔ 134PROSITE-ProRule annotation
Disulfide bondi145 ↔ 154PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		F6Q8N4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSECAG00000021277, Expressed in epithelium of bronchus and 19 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F6Q8N4, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 103TNFR-CysInterPro annotationAdd BLAST49
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati55 – 103TNFR-CysPROSITE-ProRule annotationAdd BLAST49
Domaini75 – 121Laminin EGF-likeInterPro annotationAdd BLAST47
Domaini122 – 174Laminin EGF-likeInterPro annotationAdd BLAST53
Domaini779 – 980LAM_G_DOMAINInterPro annotationAdd BLAST202
Domaini987 – 1149LAM_G_DOMAINInterPro annotationAdd BLAST163
Domaini1156 – 1316LAM_G_DOMAINInterPro annotationAdd BLAST161
Domaini1377 – 1541LAM_G_DOMAINInterPro annotationAdd BLAST165
Domaini1548 – 1721LAM_G_DOMAINInterPro annotationAdd BLAST174

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1344 – 1378DisorderedSequence analysisAdd BLAST35

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili248 – 303Sequence analysisAdd BLAST56
Coiled coili311 – 331Sequence analysisAdd BLAST21
Coiled coili352 – 372Sequence analysisAdd BLAST21
Coiled coili410 – 437Sequence analysisAdd BLAST28
Coiled coili445 – 465Sequence analysisAdd BLAST21
Coiled coili487 – 524Sequence analysisAdd BLAST38
Coiled coili528 – 555Sequence analysisAdd BLAST28
Coiled coili568 – 588Sequence analysisAdd BLAST21
Coiled coili728 – 748Sequence analysisAdd BLAST21
Coiled coili752 – 772Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155638

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002814_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		F6Q8N4

TreeFam database of animal gene trees

More...TreeFami		TF335359

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR009254, Laminin_aI
IPR010307, Laminin_dom_II
IPR002049, Laminin_EGF
IPR001791, Laminin_G
IPR001368, TNFR/NGFR_Cys_rich_reg

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00053, Laminin_EGF, 2 hits
PF02210, Laminin_G_2, 5 hits
PF06008, Laminin_I, 1 hit
PF06009, Laminin_II, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00180, EGF_Lam, 2 hits
SM00282, LamG, 5 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49899, SSF49899, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01248, EGF_LAM_1, 1 hit
PS50027, EGF_LAM_2, 2 hits
PS50025, LAM_G_DOMAIN, 5 hits
PS50050, TNFR_NGFR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F6Q8N4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPAVRWSAG WLWIFGAALG QCLGYDSQQQ RVVFLQPPGQ SHLQASYSEF 
        60         70         80         90        100
KPSQGCSPGY YRDNKGLYTG RCVPCSCNGH SHRCQDGSGI CINCQHNTAG 
       110        120        130        140        150
NHCERCKEGH YRNAVQGSCM VCPCPHSNSF ATGCVVTGGN VKCSCKPGYT 
       160        170        180        190        200
GTQCERCAPG YFGNPQKFGG SCQPCNCNNN GHLGSCDPVT GDCINQEPKD 
       210        220        230        240        250
DGPGEECDDC DSCVMTLLND LATMEGELRL VKSQLQGLSA SASTLEHMRH 
       260        270        280        290        300
LETQTKDLRN QLLNYRSAIS NHGSKMDGLE KELSNLNHEF ETLQEKVQIN 
       310        320        330        340        350
SRKVQALPNN VDRTTQRAKE LDTKIKNVIR NVHILLKQQF SGTNGEGNNV 
       360        370        380        390        400
LLGDFSRELA EADRMMRELR SRNFGKQLKD AEDGKKNAQL LLNRIRSWLE 
       410        420        430        440        450
KHQVENSGLV KSIRDSLNEY EAKLTDLRAM LQEAATQAKQ AAGLNRENQK 
       460        470        480        490        500
TLESIKRQVK EMNSLQSDFN KYLATADASL LQTSAVLQLM RKSQEEYEKL 
       510        520        530        540        550
AASLNEAKHE LRDKVKELSK SSSKTSLVVA AEKHAQSLQE LAKQLEEIKR 
       560        570        580        590        600
NTSGDELVRC AVDAATAYEN ILNAIKAAED AADKATSASE SAHQTVIKEN 
       610        620        630        640        650
LPRKAKTLSS NSEKLLNEAK ITQKKLQQEI SPALNNLQQT LKIMTVQKGL 
       660        670        680        690        700
IDTNITTIRD DLRGIQRGDI DGMINSAKSI VRNANDITNE VLDGLTPIQT 
       710        720        730        740        750
DVERIKDTYG STQSEDFNKA LGDADNSVKK LTNKLPDLLS KIESINQQLL 
       760        770        780        790        800
PLGNISDNVD RIRELIQQAR DAANKVAVPM RFNGKSGVEV RLPNDLEDLK 
       810        820        830        840        850
GYTSLSLFLQ RPDSRENGGT NNMFVMYLGK KDASRDYIGM AVVDGQLTCV 
       860        870        880        890        900
YNLGEREAEL QVDQILTESE TQESVMDRVK FQRIYQFARL NYTKKATSSK 
       910        920        930        940        950
PEATQPHDMD SGNSNTLLNL DPENAVFYVG GYPPDFRLPS RLRFPPYKGC 
       960        970        980        990       1000
IELDDLNENV LSLYNFKKTF NLNTTEVEPC RRRKEESDKN YFEGTGYARI 
      1010       1020       1030       1040       1050
PTQPNAPLPI FVQTIQTTVD RGLLFFAENQ DHFISLDIED GSLLVRYKLN 
      1060       1070       1080       1090       1100
SESPEEKGIR VIINDGKDHS IQIRIGKAQK LMRISVARED IKINGEIFDF 
      1110       1120       1130       1140       1150
STYYLGGIPI SIRERFNIST PAFRGCMKNL KKTTGVVRLN DTVGVTKKCS 
      1160       1170       1180       1190       1200
EDWKLVRSAS FSRGGQMSFT NLDFPLPSLF QASFGFQTFQ PGGILLHHQT 
      1210       1220       1230       1240       1250
RTSSLQVTLE DGHIELSTTD SSSPIFKSPQ TYMDGLLHYV SVISDTSGLR 
      1260       1270       1280       1290       1300
LLIDDQPLKN NQRLQGFSGS QQSLRLGGSH FEGCISNVFV HRSSQSPAVL 
      1310       1320       1330       1340       1350
DLASKSTKRE VSLGGCSLNE PPFLMLLKGS TRFNTAKTFS INQPLQDTPV 
      1360       1370       1380       1390       1400
ASPRSKERWR DAQSCPSPPK AQASHGALRF GDSPTSHLLF TVPQELLKSR 
      1410       1420       1430       1440       1450
SRFAVDVQTT SSRGLMFYTG TRNSFMALYL SKGRLVFALG AEGKKLKLKS 
      1460       1470       1480       1490       1500
KEKFNDGKWH TVAFGQDGEK ARLVVDGLRA REGSWPRSFT VSLRVPVYLG 
      1510       1520       1530       1540       1550
SPPSEKSKSL PQSSFVGCLR NLQLDSKPLA TPSVSFGVSP CSHGSLEKGI 
      1560       1570       1580       1590       1600
YFSQEGGHII LANSVLLGPE FKLVFSIRPR SLTGILIHIG SQRGKHLCVY 
      1610       1620       1630       1640       1650
MEAGKVTASV DSEAGGILTS VTPKRSLCDG QWHRVAVTIK KHILHLELDT 
      1660       1670       1680       1690       1700
ENSYTAGQLP FPPASAREPL HIGGVPANLQ TLKLPVWKSF FGCVKNVQVN 
      1710       1720 
HIPVPVTEAV EVQGTVSLNG CPDH
Length:1,724
Mass (Da):190,826
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i694D0AD77E8CB8A4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6ZCR0F6ZCR0_HORSE
Uncharacterized protein
LAMA3
3,274Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HXJ3A0A3Q2HXJ3_HORSE
Uncharacterized protein
LAMA3
3,331Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSECAT00000022904; ENSECAP00000018951; ENSECAG00000021277

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PaxDbiF6Q8N4

Genome annotation databases

EnsembliENSECAT00000022904; ENSECAP00000018951; ENSECAG00000021277

Phylogenomic databases

GeneTreeiENSGT00940000155638
HOGENOMiCLU_002814_0_0_1
InParanoidiF6Q8N4
TreeFamiTF335359

Gene expression databases

BgeeiENSECAG00000021277, Expressed in epithelium of bronchus and 19 other tissues
ExpressionAtlasiF6Q8N4, baseline

Family and domain databases

InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR009254, Laminin_aI
IPR010307, Laminin_dom_II
IPR002049, Laminin_EGF
IPR001791, Laminin_G
IPR001368, TNFR/NGFR_Cys_rich_reg
PfamiView protein in Pfam
PF00053, Laminin_EGF, 2 hits
PF02210, Laminin_G_2, 5 hits
PF06008, Laminin_I, 1 hit
PF06009, Laminin_II, 1 hit
SMARTiView protein in SMART
SM00180, EGF_Lam, 2 hits
SM00282, LamG, 5 hits
SUPFAMiSSF49899, SSF49899, 5 hits
PROSITEiView protein in PROSITE
PS01248, EGF_LAM_1, 1 hit
PS50027, EGF_LAM_2, 2 hits
PS50025, LAM_G_DOMAIN, 5 hits
PS50050, TNFR_NGFR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6Q8N4_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6Q8N4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: October 7, 2020
This is version 64 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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