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Entry version 67 (11 Dec 2019)
Sequence version 1 (27 Jul 2011)
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Protein
Submitted name:

Microtubule-actin cross-linking factor 1

Gene

Macf1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi4095 – 4106PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi4131 – 4142PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalciumPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule-actin cross-linking factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Macf1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:108559 Macf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, CytoskeletonPROSITE-ProRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
F6Q750

MaxQB - The MaxQuant DataBase

More...
MaxQBi
F6Q750

PeptideAtlas

More...
PeptideAtlasi
F6Q750

PRoteomics IDEntifications database

More...
PRIDEi
F6Q750

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028649 Expressed in 318 organ(s), highest expression level in lung

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F6Q750 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
F6Q750, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F6Q750

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 57SH3InterPro annotationAdd BLAST57
Domaini4082 – 4117EF-handInterPro annotationAdd BLAST36
Domaini4118 – 4153EF-handInterPro annotationAdd BLAST36
Domaini4158 – 4230GARInterPro annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni3989 – 4020DisorderedSequence analysisAdd BLAST32
Regioni4246 – 4429DisorderedSequence analysisAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili178 – 198Sequence analysisAdd BLAST21
Coiled coili535 – 565Sequence analysisAdd BLAST31
Coiled coili654 – 681Sequence analysisAdd BLAST28
Coiled coili761 – 788Sequence analysisAdd BLAST28
Coiled coili914 – 952Sequence analysisAdd BLAST39
Coiled coili1179 – 1206Sequence analysisAdd BLAST28
Coiled coili1213 – 1233Sequence analysisAdd BLAST21
Coiled coili1253 – 1280Sequence analysisAdd BLAST28
Coiled coili1291 – 1311Sequence analysisAdd BLAST21
Coiled coili1319 – 1346Sequence analysisAdd BLAST28
Coiled coili1359 – 1386Sequence analysisAdd BLAST28
Coiled coili1424 – 1444Sequence analysisAdd BLAST21
Coiled coili1668 – 1688Sequence analysisAdd BLAST21
Coiled coili1782 – 1802Sequence analysisAdd BLAST21
Coiled coili1875 – 1895Sequence analysisAdd BLAST21
Coiled coili1919 – 1939Sequence analysisAdd BLAST21
Coiled coili2026 – 2081Sequence analysisAdd BLAST56
Coiled coili2218 – 2238Sequence analysisAdd BLAST21
Coiled coili2244 – 2264Sequence analysisAdd BLAST21
Coiled coili2899 – 2919Sequence analysisAdd BLAST21
Coiled coili3132 – 3159Sequence analysisAdd BLAST28
Coiled coili3911 – 3931Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4265 – 4339PolarSequence analysisAdd BLAST75
Compositional biasi4376 – 4429PolarSequence analysisAdd BLAST54

Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516 Eukaryota
COG5069 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155824

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051 EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.920.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041615 Desmoplakin_SH3
IPR041573 Desmoplakin_Spectrin-like
IPR029926 Dystonin-like
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169:SF24 PTHR23169:SF24, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13499 EF-hand_7, 1 hit
PF02187 GAS2, 1 hit
PF17902 SH3_10, 1 hit
PF00435 Spectrin, 18 hits
PF18373 Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 2 hits
SM00243 GAS2, 1 hit
SM00150 SPEC, 31 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575 SSF143575, 1 hit
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS51460 GAR, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 18 potential isoforms that are computationally mapped.Show allAlign All

F6Q750-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
STLSVKAICD YRQIEITICK NDECVLEDNS QRTKWKVISP TGNEAMVPSV
60 70 80 90 100
CFLIPPPNKE AIEMASRVEQ SYQKVMALWH QLHINTKSLI SWNYLRKDLD
110 120 130 140 150
TVQTWSLEKL RSLAPGECHQ VMKNLQAHYE DFLQDSHDSA LFSVADRLRI
160 170 180 190 200
EEEVEACKAH FQHLMKSLEN EDKEETLAKV YISELKNIRL LLEECEQRLL
210 220 230 240 250
KQIQSPASSK TDRDARQDIT LRIAEQEHTQ EDLQHLRSDL DAISMKCNVF
260 270 280 290 300
LQQSPSGSSA TTLRSELNLM VEKMDHVYGL STVYLNKLKT IDVIVRSMQD
310 320 330 340 350
AELLVKGYEI KLSQEEAVPA DLSALESHRT TLQHWLSDVK DKNSVFSVLD
360 370 380 390 400
EEITKAKKVA EQLRHPASEP NLDLERYQEK GSQLQERWHR VIAQLETRQS
410 420 430 440 450
EVESIQEVLR DYRACHGTLI KWIEETTAQQ EMMKPGQAED SRVLSEQLSQ
460 470 480 490 500
QTELFAEIER NQTKLDQCQK FSQQYSTIVK DYELQLMTYK AFVESQQKSP
510 520 530 540 550
GKRRRMISSS DAITQEFMDL RTRYTALVTL TTQHVKYISD ALRRLEEEEK
560 570 580 590 600
VVEEEKQEHV EKVKDLLGWV STLARNTQGT TTSSHTSASA DIEKAILEQQ
610 620 630 640 650
VLAEELTTKK EQVSEAIKTS QIFLAKHGHK LSEGEKEQIS EQLRVLNKTY
660 670 680 690 700
HDLCDGSANQ LQQLQSELAQ QTEQKTLQKQ QDTCHKKLED LCNWVGQAER
710 720 730 740 750
ALERHQGGAS RQELPALQQN QSDLKDLQGD IQSHSTSFAT AVKDIEGFLE
760 770 780 790 800
ENQTKLSPQE LTALREKLHQ AKEQYEVLQE RTRVAQKELE EAVTSALQQE
810 820 830 840 850
TEKSKAATEL AENKRKIDAL LDWVASVGSS ERKPQASLPG MEQFSGACLE
860 870 880 890 900
KQTLAATDGH VDVNQVPETL DRQYELMKAR HQELLSQQQN FIVATQSVQS
910 920 930 940 950
FLDQHSHNLT PEERQKLQEK LGELKEQYAA SLARSEAELK QTQALRDELQ
960 970 980 990 1000
KFLQDHKEFE NWLQQSENEL DSMHKGGSSP EALNSLLKRQ GSFSEDVISH
1010 1020 1030 1040 1050
KGDLRFVTIS GQKVLETENN FEEGQEPSAT RNLVNEKLKD ATERYTTLHS
1060 1070 1080 1090 1100
KCIRLGSHLS MLLGQYQQFQ SSADSLQAWV LTCEASVGKL LSDTVASDPG
1110 1120 1130 1140 1150
VLQQQLATTK QLQEELAEHQ VPVEKLQKAA HDLLDIEGEP ALDCRPIQET
1160 1170 1180 1190 1200
TDSISSRFQN LSCSLDERSA LLQKAIAQSQ SVQESMESLL QSIREVEQNL
1210 1220 1230 1240 1250
ERDQVASLSS GVIQEALANN MKLKQDIARQ KSSLEATHDM VTRFMETADS
1260 1270 1280 1290 1300
NSASVLQGKL AELSQRFQQL QLQQQEKESN LKKLLPQAEM FEQLSNKLQQ
1310 1320 1330 1340 1350
FMENKSRLLA SGNQPDQDIA HFSQQIQELT LAMEDQKENL DTLEHLVTTL
1360 1370 1380 1390 1400
GSCGFALDLS QHQDKIQNLK KDFTELQKTV QEREKDASTC QEQLDEFRKL
1410 1420 1430 1440 1450
IRTFQKWLKE TEGNVPPAKT FVSAKELEKQ IEHLKDLISD WESKGALLGE
1460 1470 1480 1490 1500
INAKGTALES LIMDITAPDS QAKTDLTEIQ CDMFDVNSKY EKLWEVLRER
1510 1520 1530 1540 1550
QESLQTVFSR MEEVQKEASS VLQWLESKEE VLKAMDATLS PTKTETVKAQ
1560 1570 1580 1590 1600
AESNKAFLAE LEQNSPKIQK VKEALAGLLK TYPNSQEAEN WKKMQEDLNS
1610 1620 1630 1640 1650
RWEKATEVTV ARQKQLEESA SHLACFQAAE SQLRPWLMEK ELMMGVLGPL
1660 1670 1680 1690 1700
SIDPNMLNAQ KQQVQFMLKE FEARRQQHEQ LNEAAQGILT GPGDMSPSAS
1710 1720 1730 1740 1750
QVHKDLQSIS QKWVELTDKL NSRSSQIDQA IVKSTQYQDL LQDLSEKVKA
1760 1770 1780 1790 1800
IGQRLSGQSA ISTQPEAVKQ QLEETSEIRS DLGQLDNEIK EAQTLCQELS
1810 1820 1830 1840 1850
LLIGEQYLKD ELKKRLETVA LPLQGLEDLA ADRMNRLQAA LASTQQFQQM
1860 1870 1880 1890 1900
FDELRTWLDE KQSQQAKNCP ISAKLERLQC QLQENEEFQK NLNQHSGSYE
1910 1920 1930 1940 1950
VIVAEGEALL LSVPPGEEKK TLQNQLVELR SHWEDLSKKT ANRQSRLKDC
1960 1970 1980 1990 2000
MQKAQKYQGH VEDLVPWIDE CKSKMSELQV TLDPVQLESS LLRSKAMLNE
2010 2020 2030 2040 2050
AEKRRSLLEI LNSAADILIN SSEIDEDEIR DEKAGLNQNM DAITEELQAK
2060 2070 2080 2090 2100
TSSLEEMTQR LKEFQESFKN IEKKVEGAKH QLEIFDALGS QACSNKNLEK
2110 2120 2130 2140 2150
LKAQQEVLQA LEPQVDYLRN FTQGLVEDAP DGSDASPLVH QAEVAQQEFL
2160 2170 2180 2190 2200
EVKQRVSSSC LTMENKLEGI GQFHCRVREM FSQLADLDDE LDGMGAIGRD
2210 2220 2230 2240 2250
TDSLQSQIED VRLFLNKIQA LRFDIEDSEA ECRKMLEEEG TLDLLGLKRE
2260 2270 2280 2290 2300
LEALNKQCGK LTERGKVRQE QLELTLGRVE DFYRKLKALN DAATAAEEGE
2310 2320 2330 2340 2350
ALQWIVGTEV DVINQQLADF KLFQKDQVDP LQVKLQQVNG LGQGLIQSAG
2360 2370 2380 2390 2400
KNCDVQGLEH DMDEINTRWN TLNKKVAQRI AQLQEALLHC GKFQDALEPL
2410 2420 2430 2440 2450
LSWLTDTEEL IANQKPPSAE YKVVKAQIQE QKLLQRLLDD RKATVDMLQA
2460 2470 2480 2490 2500
EGGRIAQSAE LADREKITGQ LESLERRWTD LLSKAAARQK QLEDILVLAK
2510 2520 2530 2540 2550
QFHETAEPIS DFLSVTEKKL ANSEPVGTQT AKIHQQIIRH KALNEEIINR
2560 2570 2580 2590 2600
KKNVDQAIKN GQALLKQTTG EEVLLIQEKL DGIKTRYADI TLTSSKALRT
2610 2620 2630 2640 2650
LEQARQLATK FHSTYEELTG WLREAEEELA ASGGQSPTGE QIPQFQQRQK
2660 2670 2680 2690 2700
ELKKEVMEHR LVLDTVNEVS HALLELVPWR AREGLDKLVS DANEQYKLIS
2710 2720 2730 2740 2750
DTVGQRVDEI DAAIQRSQQY EQAADAELAW VAETKRKLMA LGPIRLEQDQ
2760 2770 2780 2790 2800
TTAQLQVQKA FSIDIIRHKD SMDELFSHRG EIFSTCGEEQ KAVLQEKTEC
2810 2820 2830 2840 2850
LIQQYEAVSL LNSERYARLE RAQVLVNQFW ETYEELSPWA EETLALIAQL
2860 2870 2880 2890 2900
PPPAVDHEQL RQQQEEMRQL RESIAEHKPH IDKILKIGPQ LKELNPEEGK
2910 2920 2930 2940 2950
MVEEKYQKAE NMYAQIKDEV RQRALALDEA VSQSAQFHDK IEPMLETLEN
2960 2970 2980 2990 3000
LSSRLRMPPL IPAEVDKIRE CISDNKSATV ELEKLQPSFE ALKRRGEELI
3010 3020 3030 3040 3050
GRSQGADKDL AAKEIQDKLD QMVFFWEDIK ARSEEREIKF LDVLELAEKF
3060 3070 3080 3090 3100
WYDMAALLTT IKDTQDIVHD LESPGIDPSI IKQQVEAAET IKEETDGLHE
3110 3120 3130 3140 3150
ELEFIRILGA DLIFACGETE KPEVKKSIDE MNNAWENLNK TWKERLEKLE
3160 3170 3180 3190 3200
DAMQAAVQYQ DTLQAMFDWL DNTVIKLCTM PPVGTDLNTV KDQLNEMKEF
3210 3220 3230 3240 3250
KVEVYQQQIE MEKLNHQGEL MLKKATDETD RDIIREPLTE LKHLWENLGE
3260 3270 3280 3290 3300
KIAHRQHKLE GALLALGQFQ HALEELMSWL THTEELLDAQ RPISGDPKVI
3310 3320 3330 3340 3350
EVELAKHHVL KNDVLAHQAT VATVNKAGSE LLESSAGDDA SSLRSRLETM
3360 3370 3380 3390 3400
NQCWESVLQK TEEREQQLQS TLQQAQGFHS EIEDFLLELN RMENQLSASK
3410 3420 3430 3440 3450
PTGGLPETAR EQLDTHMELH SQLRAKEEIY NQLLDKGRLM LLSRGDSGSG
3460 3470 3480 3490 3500
SKTEQSVALL EQKWHAVSSK VEERKSKLEE ALSLATEFQN SLQEFINWLT
3510 3520 3530 3540 3550
LAEQSLNIAS PPSLILNTVL SQIEEHKVFA NEVNDHRDQI IELDQTGNQL
3560 3570 3580 3590 3600
KFLSQKQDVV LIKNLLVSVQ SRWEKVVQRS IERGRSLDDA RKRAKQFHEA
3610 3620 3630 3640 3650
WKKLIDWLED AESHLDSELE ISNDPDKIKL QLSKHKEFQK TLGGKQPVYD
3660 3670 3680 3690 3700
TTIRTGRALK EKTLLAGDTQ KLDNLLGEVR DKWDTVCGKS VERQHKLEEA
3710 3720 3730 3740 3750
LLFSGQFMDA LQALVDWLYK VEPQLAEDQP VHGDLDLVMN LMDAHKVFQK
3760 3770 3780 3790 3800
ELGKRTGTVQ VLKRSGRELI EGSRDDTTWV KGQLQELSTR WDTVCKLSVS
3810 3820 3830 3840 3850
KQSRLEQALK QAEEFRDTVH MLLEWLSEAE QTLRFRGALP DDTEALQSLI
3860 3870 3880 3890 3900
DTHKEFMKKV EEKRVDVNTA VAMGEAILAV CHPDCITTIK HWITIIRARF
3910 3920 3930 3940 3950
EEVLTWAKQH QQRLETALSE LVANAELLEE LLAWIQWAET TLIQRDQEPI
3960 3970 3980 3990 4000
PQNIDRVKAL ITEHQSFMEE MTRKQPDVDR VTKTYKRKSV EPTHAPFMEK
4010 4020 4030 4040 4050
SRSGSRKSLN QPTPPPMPIL SQSEAKNPRI NQLSARWQQV WLLALERQRK
4060 4070 4080 4090 4100
LNDALDRLEE LKEFANFDFD VWRKKYMRWM NHKKSRVMDF FRRIDKDQDG
4110 4120 4130 4140 4150
KITRQEFIDG ILASKFPTTK LEMTAVADIF DRDGDGYIDY YEFVAALHPN
4160 4170 4180 4190 4200
KDAYRPTTDA DKIEDEVTRQ VAQCKCAKRF QVEQIGENKY RFGDSQQLRL
4210 4220 4230 4240 4250
VRILRSTVMV RVGGGWMALD EFLVKNDPCR ARGRTNIELR EKFILPEGAS
4260 4270 4280 4290 4300
QGMTPFRSRG RRSKPSSRAA SPTRSSSSAS QSNHSCTSMP SSPATPASGT
4310 4320 4330 4340 4350
KVISSSGSKL KRPTPAFHSS RTSLAGDTSN SSSPASTGAK ANRADPKKSA
4360 4370 4380 4390 4400
SRPGSRAGSR AGSRASSRRG SDASDFDLLE TQSACSDTSE SSAAGGQGSS
4410 4420
RRGLTKPSKI PTMSKKTTTA SPRTPGPKR
Length:4,429
Mass (Da):504,231
Last modified:July 27, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i504D1186E6DADB15
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 18 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9QXZ0MACF1_MOUSE
Microtubule-actin cross-linking fac...
Macf1 Acf7, Aclp7, Macf
7,354Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PVY8E9PVY8_MOUSE
Microtubule-actin cross-linking fac...
Macf1
7,355Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQA6A0A0A0MQA6_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,328Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ARU4B1ARU4_MOUSE
Microtubule-actin cross-linking fac...
Macf1
7,353Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7ACR9F7ACR9_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,333Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QA63E9QA63_MOUSE
Microtubule-actin cross-linking fac...
Macf1
7,351Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QNP1E9QNP1_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,478Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ARU1B1ARU1_MOUSE
Microtubule-actin cross-linking fac...
Macf1
5,895Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YKN8F6YKN8_MOUSE
Microtubule-actin cross-linking fac...
Macf1
544Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RCJ3F6RCJ3_MOUSE
Microtubule-actin cross-linking fac...
Macf1
452Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL606918 Genomic DNA No translation available.
AL606932 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000134458; ENSMUSP00000119885; ENSMUSG00000028649

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL606918 Genomic DNA No translation available.
AL606932 Genomic DNA No translation available.

3D structure databases

SMRiF6Q750
ModBaseiSearch...

Protein-protein interaction databases

IntActiF6Q750, 1 interactor

Proteomic databases

EPDiF6Q750
MaxQBiF6Q750
PeptideAtlasiF6Q750
PRIDEiF6Q750

Genome annotation databases

EnsembliENSMUST00000134458; ENSMUSP00000119885; ENSMUSG00000028649

Organism-specific databases

MGIiMGI:108559 Macf1

Phylogenomic databases

eggNOGiKOG0516 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00940000155824

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Macf1 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028649 Expressed in 318 organ(s), highest expression level in lung
ExpressionAtlasiF6Q750 baseline and differential

Family and domain databases

CDDicd00051 EFh, 1 hit
Gene3Di3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR041615 Desmoplakin_SH3
IPR041573 Desmoplakin_Spectrin-like
IPR029926 Dystonin-like
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR003108 GAR_dom
IPR036534 GAR_dom_sf
IPR001452 SH3_domain
IPR018159 Spectrin/alpha-actinin
IPR002017 Spectrin_repeat
PANTHERiPTHR23169:SF24 PTHR23169:SF24, 2 hits
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF02187 GAS2, 1 hit
PF17902 SH3_10, 1 hit
PF00435 Spectrin, 18 hits
PF18373 Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SM00243 GAS2, 1 hit
SM00150 SPEC, 31 hits
SUPFAMiSSF143575 SSF143575, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS51460 GAR, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6Q750_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6Q750
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: December 11, 2019
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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