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Entry version 59 (02 Jun 2021)
Sequence version 3 (02 Dec 2020)
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Protein
Submitted name:

FH2 domain containing 1

Gene

FHDC1

Organism
Ornithorhynchus anatinus (Duckbill platypus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FH2 domain containing 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FHDC1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOrnithorhynchus anatinus (Duckbill platypus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9258 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMonotremataOrnithorhynchidaeOrnithorhynchus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002279 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSOANG00000005286, Expressed in brain and 9 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9258.ENSOANP00000008414

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 96DisorderedSequence analysisAdd BLAST96
Regioni597 – 631DisorderedSequence analysisAdd BLAST35
Regioni643 – 663DisorderedSequence analysisAdd BLAST21
Regioni722 – 1167DisorderedSequence analysisAdd BLAST446

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili375 – 395Sequence analysisAdd BLAST21
Coiled coili410 – 430Sequence analysisAdd BLAST21
Coiled coili462 – 482Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi27 – 89Pro residuesSequence analysisAdd BLAST63
Compositional biasi612 – 631Polar residuesSequence analysisAdd BLAST20
Compositional biasi753 – 771Polar residuesSequence analysisAdd BLAST19
Compositional biasi897 – 914Polar residuesSequence analysisAdd BLAST18
Compositional biasi1016 – 1035Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1038 – 1057Pro residuesSequence analysisAdd BLAST20
Compositional biasi1059 – 1073Polar residuesSequence analysisAdd BLAST15
Compositional biasi1138 – 1155Basic and acidic residuesSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1922, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155128

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009023_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6Q350

Identification of Orthologs from Complete Genome Data

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OMAi
LECWKQE

Database of Orthologous Groups

More...
OrthoDBi
1204639at2759

TreeFam database of animal gene trees

More...
TreeFami
TF324020

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.2220, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02181, FH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00498, FH2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51444, FH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F6Q350-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHVMNCVSLA SDKENGDISV TAGLMIGQTP PPPPPPPPPP PPPPPLPPCP
60 70 80 90 100
FPDAGFAPPL PPPPPPPPPL PGGPPAPPPP PPGLPPPSPF YNGHGHLSKK
110 120 130 140 150
KRMRNFFWKT IPEEQVRGKT NIWTIAARQQ HHYQIDTKTV EELFGQQEDT
160 170 180 190 200
NSPAFRRSGS LNSSFKDAKE ESTILDAKRS MNVGIFLKQF KKSPQFIVED
210 220 230 240 250
IHRGKSEHYG SETLREFLKV LPESEEVKKL KAFSGDVSKL SLADSFMYFL
260 270 280 290 300
IQVPNYSLRM EAMVLKKEFL PSCSSLYKDM TVLRAATKEL MSCEELHSIL
310 320 330 340 350
HLVLQAGNIM NAGGYAGNAV GFKLSSLLKL ADTKANKPGM NLLHFVALEA
360 370 380 390 400
QKKDVVLLIF SEKLHHVQDA ARLSLDNTEA ELHSLSARTR CLRENIQRDP
410 420 430 440 450
ELFQQMEDFI QFALKKLKEL EQWKQVLQEE AHTLIDFFCE DKETMKLDEC
460 470 480 490 500
FQIFRDFCTK FNKAVKDNRE REVQELRQLQ KLKEVEGKRR SWAAGELGGF
510 520 530 540 550
GRSSSENDVE LLTKKGLEDF LPFLQQRPLS PSSRVPANSR RSRLSLGTSA
560 570 580 590 600
DRELLTFLET STGEEPNKFN SLPRASARQA WPAETWMEAQ ETRDLNSNHV
610 620 630 640 650
HLDPAPGPGG SSGNSPPLQP SLLQDLDEPR STSARLYQAQ NRANANHPQR
660 670 680 690 700
MGGPGGSAPA SAPARCPLAV EIEERELVGS LIRFDLQGPR GSGEQSGVTM
710 720 730 740 750
EDFSPMELES LEADISLQSF SAADDSSGPY SPCSRDTADW KGSGLDQRGV
760 770 780 790 800
GAGMSLPTST TPASLDTSDS ESKEPGPVFY ISDTTDCSLT LDCSEGNDVK
810 820 830 840 850
TADRETEDEA AGGPVLPGSG DPEGEKGSGL VSDPNCSSVG EGPALFSGRD
860 870 880 890 900
EPNSKRGPTG GCRAAKGRDL VAPKRNSVKD QPASAPKPGT APRGQGSVAK
910 920 930 940 950
SIRTLNSSEN ESMRKVVPIS KASRGSGGWK RPEGPGRGAP REGPSSGPDA
960 970 980 990 1000
RLARRSSVRG TADTSPRRPV GSMVVAIEEQ RWLRGGPASG ATRPGREPPQ
1010 1020 1030 1040 1050
RRSSLKKPSA KPVRNLPKPK LEETKICRSN SREPEGPEEA APSPPVASAP
1060 1070 1080 1090 1100
RVPPPTPSFA RNTVASSSRR LKSDLPPASK PPSLMRAASQ RQLKVKTGPE
1110 1120 1130 1140 1150
DPGSKESGVL RRASSARAAR RGPEPSESPG PRGEGPGRAR GPPEKPSHKL
1160
KEGSRTTLGK ILNPLWK
Length:1,167
Mass (Da):126,636
Last modified:December 2, 2020 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13EBF19AA8FEC093
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_001511976.1, XM_001511926.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSOANT00000008416; ENSOANP00000008414; ENSOANG00000005286

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_001511976.1, XM_001511926.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9258.ENSOANP00000008414

Genome annotation databases

EnsembliENSOANT00000008416; ENSOANP00000008414; ENSOANG00000005286

Phylogenomic databases

eggNOGiKOG1922, Eukaryota
GeneTreeiENSGT00940000155128
HOGENOMiCLU_009023_0_0_1
InParanoidiF6Q350
OMAiLECWKQE
OrthoDBi1204639at2759
TreeFamiTF324020

Gene expression databases

BgeeiENSOANG00000005286, Expressed in brain and 9 other tissues

Family and domain databases

Gene3Di1.20.58.2220, 1 hit
InterProiView protein in InterPro
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
PfamiView protein in Pfam
PF02181, FH2, 1 hit
SMARTiView protein in SMART
SM00498, FH2, 1 hit
PROSITEiView protein in PROSITE
PS51444, FH2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6Q350_ORNAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6Q350
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 2, 2020
Last modified: June 2, 2021
This is version 59 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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