UniProtKB - F6PYK5 (F6PYK5_HORSE)
Protein
Endothelin receptor non-selective type
Gene
EDNRB
Organism
Equus caballus (Horse)
Status
Functioni
GO - Molecular functioni
- endothelin receptor activity Source: InterPro
GO - Biological processi
- enteric nervous system development Source: InterPro
- regulation of blood pressure Source: InterPro
- vasoconstriction Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotationARBA annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Endothelin receptor non-selective typeARBA annotationAlternative name(s): Endothelin receptor type BARBA annotation |
Gene namesi | Name:EDNRBImported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:17425, EDNRB |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 103 – 127 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 139 – 160 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 180 – 198 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 218 – 235 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 276 – 302 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 322 – 342 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 362 – 390 | HelicalSequence analysisAdd BLAST | 29 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_5018605165 | 27 – 443 | Endothelin receptor non-selective typeSequence analysisAdd BLAST | 417 |
Keywords - PTMi
Disulfide bondARBA annotation, Lipoprotein, PalmitateARBA annotationExpressioni
Gene expression databases
Bgeei | ENSECAG00000024851, Expressed in endometrium and 19 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 119 – 387 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 269 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 89 | DisorderedSequence analysisAdd BLAST | 60 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 47 – 67 | PolarSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT01010000222518 |
HOGENOMi | CLU_009579_28_0_1 |
TreeFami | TF331292 |
Family and domain databases
InterProi | View protein in InterPro IPR000499, Endthln_rcpt IPR001112, ETB_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00571, ENDOTHELINBR PR00366, ENDOTHELINR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
F6PYK5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQPLPTLCGR VLVALILACG VAGVQGEERR FPPARATPPL LGSEEIMTPP
60 70 80 90 100
TKTSWPTGSN ASVPRSSAPP QMPKAGRTAG AQRRTLPPPP CERTIEIKET
110 120 130 140 150
FKYINTVVSC LVFVLGIIGN STLLRIIYKN KCMRNGPNIL IASLALGDLL
160 170 180 190 200
HIIIDIPINV YKLLAEDWPF GVEMCKLVPF IQKASVGITV LSLCALSIDR
210 220 230 240 250
YRAVASWSRI KGIGVPKWTA VEIVLIWVVS VVLAVPEAVG FDMITADYKG
260 270 280 290 300
SYLRICLLHP TQKTAFMQFY KNAKDWWLFS FYFCLPLAIT AFFYTLMTCE
310 320 330 340 350
MLRKKSGMQI ALNDHLKQRR EVAKTVFCLV LVFALCWLPL HLSRILKHTL
360 370 380 390 400
YDQNDPHRCE LLSFLLVLDY IGINMASLNS CINPIALYLV SKRFKNCFKS
410 420 430 440
CLCCWCQSFE EKQSLEDKQS CLKFKANDHG YDNFRSSNKY SSS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2LBB2 | A0A3Q2LBB2_HORSE | Endothelin receptor non-selective t... | EDNRB | 447 | Annotation score: | ||
A0A3Q2I0G2 | A0A3Q2I0G2_HORSE | Endothelin receptor non-selective t... | EDNRB | 442 | Annotation score: | ||
A0A5F5PT63 | A0A5F5PT63_HORSE | Endothelin receptor non-selective t... | EDNRB | 407 | Annotation score: |
Sequence databases
RefSeqi | NP_001075306.2, NM_001081837.2 XP_014587501.1, XM_014732015.1 |
Genome annotation databases
Ensembli | ENSECAT00000026836; ENSECAP00000022427; ENSECAG00000024851 |
GeneIDi | 100033875 |
KEGGi | ecb:100033875 |
Similar proteinsi
Cross-referencesi
Sequence databases
RefSeqi | NP_001075306.2, NM_001081837.2 XP_014587501.1, XM_014732015.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
GPCRDBi | Search... |
Genome annotation databases
Ensembli | ENSECAT00000026836; ENSECAP00000022427; ENSECAG00000024851 |
GeneIDi | 100033875 |
KEGGi | ecb:100033875 |
Organism-specific databases
CTDi | 1910 |
VGNCi | VGNC:17425, EDNRB |
Phylogenomic databases
GeneTreei | ENSGT01010000222518 |
HOGENOMi | CLU_009579_28_0_1 |
TreeFami | TF331292 |
Gene expression databases
Bgeei | ENSECAG00000024851, Expressed in endometrium and 19 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000499, Endthln_rcpt IPR001112, ETB_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00571, ENDOTHELINBR PR00366, ENDOTHELINR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F6PYK5_HORSE | |
Accessioni | F6PYK5Primary (citable) accession number: F6PYK5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 27, 2011 |
Last sequence update: | April 10, 2019 | |
Last modified: | December 2, 2020 | |
This is version 53 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |