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Entry version 50 (26 Feb 2020)
Sequence version 2 (10 Apr 2019)
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Protein
Submitted name:

Metastasis associated 1 family member 2

Gene

MTA2

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Metastasis associated 1 family member 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MTA2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:20399 MTA2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusSAAS annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6PQI8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSECAG00000009847 Expressed in liver and 2 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini591 – 761WD_REPEATS_REGIONInterPro annotationAdd BLAST171
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati591 – 623WDPROSITE-ProRule annotationAdd BLAST33
Repeati720 – 753WDPROSITE-ProRule annotationAdd BLAST34
Domaini778 – 918BAHInterPro annotationAdd BLAST141
Domaini919 – 1030ELM2InterPro annotationAdd BLAST112
Domaini1037 – 1089SANTInterPro annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni50 – 207DisorderedSequence analysisAdd BLAST158
Regioni1186 – 1212DisorderedSequence analysisAdd BLAST27
Regioni1354 – 1373DisorderedSequence analysisAdd BLAST20
Regioni1421 – 1442DisorderedSequence analysisAdd BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili16 – 43Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi78 – 92PolarSequence analysisAdd BLAST15
Compositional biasi111 – 132PolarSequence analysisAdd BLAST22
Compositional biasi147 – 163PolarSequence analysisAdd BLAST17
Compositional biasi170 – 191PolarSequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis, WD repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3554 Eukaryota
ENOG410XSAJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159589

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006585_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6PQI8

TreeFam database of animal gene trees

More...
TreeFami
TF106444

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00202 ZnF_GATA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001025 BAH_dom
IPR000949 ELM2_dom
IPR005108 HELP
IPR009057 Homeobox-like_sf
IPR035170 MTA1_R1
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR000679 Znf_GATA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01426 BAH, 1 hit
PF01448 ELM2, 1 hit
PF00320 GATA, 1 hit
PF03451 HELP, 1 hit
PF17226 MTA_R1, 1 hit
PF00400 WD40, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00439 BAH, 1 hit
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00320 WD40, 7 hits
SM00401 ZnF_GATA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51038 BAH, 1 hit
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F6PQI8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGAGGPGEG PAQEVLRSLS QRLQVQEKEM ELVKAALAEA LRLLRLQAPP
60 70 80 90 100
TSLQDAGIPA PTRDSPAAPP GLPPTCSPSL VSRGTQTEVQ MEPSPGPPGL
110 120 130 140 150
SNGPPAPQGG SEEPSGTQSE GGGSSSSGTG SPGPPGILRL VQPPQRADTP
160 170 180 190 200
RRNSSSSSSP SERPRQKLSR KAASSANLLL RSGSTESRGG KDPLSSPGGP
210 220 230 240 250
GSRRSNYNLE GISVKMFLRG RPITMYIPSG IRSLEELPSG PPPETLSLDW
260 270 280 290 300
VYGYRGRDSR SNLFVLRSGE VVYFIACVVV LYRPGGGPGG PGGGGQRHYR
310 320 330 340 350
GHTDCVRCLA VHPDGVRVAS GQTAGVDKDG KPLQPVVHVW DSETLLKLQE
360 370 380 390 400
IGLGAFERGV GALAFSVADQ GAFLCVVDDS NEHMLSVWDC SRGTKLAEIK
410 420 430 440 450
STNDSVLAVG FSPRDSSCIV TSGKSHVHFW NWSGGVGVPG NGTLTRKQGV
460 470 480 490 500
FGKYKKPKFI PCFVFLPDGD ILTGDSEGNI LTWGRSLSDS RTPGRGGAKE
510 520 530 540 550
TYGIVAQAHA HEGSIFALCL RRDGTVLSGG GRDRRLVQWG PGLVALQEAE
560 570 580 590 600
IPEHFGAVRA IAEGLGSELL VGTTKNALLR GDLAQGFSPV IQGHTDELWG
610 620 630 640 650
LCTHPFQNRF LTCGHDRQLC LWDGEGHALA WSIDLKETGL CADFHPSGAV
660 670 680 690 700
VAVGLNTGRW LVLDTETREI VSDVTDGNEQ LSVVRYSPDG LYLAIGSHDN
710 720 730 740 750
MIYIYSVSSD GAKSSRFGRC VGHSSFITHL DWSKDGNFIM SNSGDYEILY
760 770 780 790 800
WDVAGGCKLL RNRYESRDRE WATYTCVLGF HVYDYVYFEN SSSNPYLVRR
810 820 830 840 850
IEELNKTANG NVEAKVVCLF RRRDISSSLN SLADSNAREF EEESKQPGVS
860 870 880 890 900
EQQRHQLKHR ELFLSRQFES LPATHIRGKC SVTLLNETDI LSQYLEKEDC
910 920 930 940 950
FFYSLVFDPV QKTLLADQGE IRVGCKYQAE IPDRLAEGES DNRNQQKMEM
960 970 980 990 1000
KVWDPDNPLT DRQIDQFLVV ARAVGTFARA LDCSSSIRQP SLHMSAAAAS
1010 1020 1030 1040 1050
RDITLFHAMD TLQRNGYDLA KAMSTLVPQG GPVLCRDEME EWSASEAMLF
1060 1070 1080 1090 1100
EEALEKYGKD FNDIRQDFLP WKSLASIVQF YYMWKTTDRY IQQKRLKAAE
1110 1120 1130 1140 1150
ADSKLKQVYI PTYTKPNPNQ IVSVGSKPGM NGAGFQKGLT CESCHTTQSA
1160 1170 1180 1190 1200
QWYAWGPPNM QCRLCASCWI YWKKYGGLKT PTQLEGAARG TTEPHSRSHL
1210 1220 1230 1240 1250
SRPEAQSLSP YTTSANRAKL LAKNRQTFLL QTTKLTRLAR RMCRDLLQPR
1260 1270 1280 1290 1300
RAARRPYAPI NANAIKAECS IRLPKAAKTP LKIHPLVRLP LATIVKDLVA
1310 1320 1330 1340 1350
QAPLKPKTPR GTKTPINRNQ LTQNRGLGGI MVKRPYETMA GAGVPFSANG
1360 1370 1380 1390 1400
RPLASGIRSS SQPAAKRQKL NPADAPNPVV FVATKDTRAL RKALTHLEMR
1410 1420 1430 1440
RAARRPNLPL KVKPPLIAVR PPVPLPAPSH PASTNEPIVL ED
Length:1,442
Mass (Da):157,479
Last modified:April 10, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84DB90FA73B269F4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F5PJD5A0A5F5PJD5_HORSE
Metastasis associated 1 family memb...
MTA2
908Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5PMR8A0A5F5PMR8_HORSE
Metastasis associated 1 family memb...
MTA2
668Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000010563; ENSECAP00000008166; ENSECAG00000009847

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PaxDbiF6PQI8

Genome annotation databases

EnsembliENSECAT00000010563; ENSECAP00000008166; ENSECAG00000009847

Organism-specific databases

VGNCiVGNC:20399 MTA2

Phylogenomic databases

eggNOGiKOG3554 Eukaryota
ENOG410XSAJ LUCA
GeneTreeiENSGT00940000159589
HOGENOMiCLU_006585_2_0_1
InParanoidiF6PQI8
TreeFamiTF106444

Gene expression databases

BgeeiENSECAG00000009847 Expressed in liver and 2 other tissues

Family and domain databases

CDDicd00202 ZnF_GATA, 1 hit
Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR001025 BAH_dom
IPR000949 ELM2_dom
IPR005108 HELP
IPR009057 Homeobox-like_sf
IPR035170 MTA1_R1
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR000679 Znf_GATA
PfamiView protein in Pfam
PF01426 BAH, 1 hit
PF01448 ELM2, 1 hit
PF00320 GATA, 1 hit
PF03451 HELP, 1 hit
PF17226 MTA_R1, 1 hit
PF00400 WD40, 3 hits
SMARTiView protein in SMART
SM00439 BAH, 1 hit
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00320 WD40, 7 hits
SM00401 ZnF_GATA, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS51038 BAH, 1 hit
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6PQI8_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6PQI8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: April 10, 2019
Last modified: February 26, 2020
This is version 50 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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