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Protein

DNA polymerase

Gene

pold1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation

Enzyme and pathway databases

ReactomeiR-XTR-110314 Recognition of DNA damage by PCNA-containing replication complex
R-XTR-174411 Polymerase switching on the C-strand of the telomere
R-XTR-174414 Processive synthesis on the C-strand of the telomere
R-XTR-174417 Telomere C-strand (Lagging Strand) Synthesis
R-XTR-174437 Removal of the Flap Intermediate from the C-strand
R-XTR-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-XTR-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
R-XTR-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-XTR-5656169 Termination of translesion DNA synthesis
R-XTR-5685942 HDR through Homologous Recombination (HRR)
R-XTR-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-XTR-5696400 Dual Incision in GG-NER
R-XTR-6782135 Dual incision in TC-NER
R-XTR-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-XTR-69091 Polymerase switching
R-XTR-69166 Removal of the Flap Intermediate
R-XTR-69183 Processive synthesis on the lagging strand

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:pold1Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1002131 pold1

Expressioni

Gene expression databases

BgeeiENSXETG00000009036
ExpressionAtlasiF6PL17 baseline

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 482DNA_pol_B_exo1InterPro annotationAdd BLAST358
Domaini540 – 904DNA_pol_BInterPro annotationAdd BLAST365

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00560000077365

Family and domain databases

Gene3Di3.30.420.10, 1 hit
3.90.1600.10, 2 hits
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR023211 DNA_pol_palm_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

Sequencei

Sequence statusi: Complete.

F6PL17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFKRKKGQA SGLPASQTKK LRGDWDDDAP SQFEEELAFM DEVEAEMAME
60 70 80 90 100
LSEGQLSADI LPVGKLISDN IPPKWLRPPV SLTDPKEQTL CFQQVELDHY
110 120 130 140 150
VGDHVSGMLG ATQGPVPIIR MFGITEEGNS VCCHIHGFAP YFYVPCHTGF
160 170 180 190 200
KQEDLSDFKK ELNSAVIKDM RSNKDSISQA VLAVDVCHKE NMYGYHGKKI
210 220 230 240 250
IPFMKITMAL PRLIAPAKRL LEQGLRFGRH PTHCYQAYEA NIDFEIRFMV
260 270 280 290 300
DNDIVGCNWI ELPAGKYRLR KESQDEGPSK ENPSKVSLAQ IEVDISWADL
310 320 330 340 350
ISHPAEGDWQ KIAPLRVLSF DIECAGRKGV FPEPDKDPVI QIANMVLRQG
360 370 380 390 400
EKDAFIRNVF TLGTCSSIVG SQVLCFDRED ALLKAWADFV RTIDPDIITG
410 420 430 440 450
YNIQNFDMPY LINRAQTLKV PNFPFLGRIR SMKSVIRDSS FQSKQMGRRE
460 470 480 490 500
NKVINTEGRV QFDLLQVLLR DYKLRSYTLN AVSFHFLQEQ KEDVQHSIIT
510 520 530 540 550
DLQNGNEQTR RRLAVYCLKD AYLPLRLMEK LMCVINYMEM ARVTGVPLSY
560 570 580 590 600
LLSRGQQIKV VSQLLRQAMK QDLVMPVVKS EGGEDYTGAT VIEPLKGYYD
610 620 630 640 650
VPIATLDFSS LYPSIMMAHN LCYTTLLQTP NVSSPLNYMK TMGLFVSSYL
660 670 680 690 700
PNPLMETIAE FTSLCFRAKA ELKKETDPFK QKVLDGRQLA LKVSANSVYG
710 720 730 740 750
FTGAQVGKLP CLEISQSVTG FGRQMIEKTK QLVESKYTLD NGYKADAKVI
760 770 780 790 800
YGDTDSVMCK LGVQTVVEAM EIGREAAEWV SSHFTPPIKL EFEKVYFPYL
810 820 830 840 850
LINKKRYAGL YFSSSANTHD KMDCKGIETV RRDNCPLVAN LINTCLQKIL
860 870 880 890 900
IDRDPMGAVE HAKDVISDLL CNRIDISQLV ITKELTRTAD EYAGKQAHVE

LAER
Length:904
Mass (Da):102,143
Last modified:July 27, 2011 - v1
Checksum:i75F0D74C3A004952
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01035895 Genomic DNA No translation available.
AAMC01035896 Genomic DNA No translation available.
AAMC01035897 Genomic DNA No translation available.
AAMC01035898 Genomic DNA No translation available.
AAMC01035899 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSXETT00000065576; ENSXETP00000061925; ENSXETG00000009036

Similar proteinsi

Entry informationi

Entry nameiF6PL17_XENTR
AccessioniPrimary (citable) accession number: F6PL17
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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