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Entry version 46 (02 Jun 2021)
Sequence version 3 (11 Dec 2019)
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Protein
Submitted name:

Proline rich coiled-coil 2B

Gene

PRRC2B

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell differentiation Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Proline rich coiled-coil 2BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRRC2BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri13616 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002280 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMODG00000012428, Expressed in spermatid and 21 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
13616.ENSMODP00000015558

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni44 – 262DisorderedSequence analysisAdd BLAST219
Regioni386 – 660DisorderedSequence analysisAdd BLAST275
Regioni783 – 802DisorderedSequence analysisAdd BLAST20
Regioni810 – 842DisorderedSequence analysisAdd BLAST33
Regioni885 – 913DisorderedSequence analysisAdd BLAST29
Regioni965 – 1079DisorderedSequence analysisAdd BLAST115
Regioni1171 – 1201DisorderedSequence analysisAdd BLAST31
Regioni1414 – 1536DisorderedSequence analysisAdd BLAST123

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi89 – 142Polar residuesSequence analysisAdd BLAST54
Compositional biasi200 – 254Polar residuesSequence analysisAdd BLAST55
Compositional biasi409 – 423Polar residuesSequence analysisAdd BLAST15
Compositional biasi455 – 478Polar residuesSequence analysisAdd BLAST24
Compositional biasi479 – 526Basic and acidic residuesSequence analysisAdd BLAST48
Compositional biasi534 – 551Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi581 – 657Polar residuesSequence analysisAdd BLAST77
Compositional biasi817 – 833Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi965 – 1007Polar residuesSequence analysisAdd BLAST43
Compositional biasi1025 – 1070Basic and acidic residuesSequence analysisAdd BLAST46
Compositional biasi1176 – 1201Polar residuesSequence analysisAdd BLAST26
Compositional biasi1454 – 1480Polar residuesSequence analysisAdd BLAST27
Compositional biasi1505 – 1521Polar residuesSequence analysisAdd BLAST17

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4817, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183161

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001247_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
F6PKE2

Database of Orthologous Groups

More...
OrthoDBi
17901at2759

TreeFam database of animal gene trees

More...
TreeFami
TF328738

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009738, BAT2_N
IPR033184, PRRC2

The PANTHER Classification System

More...
PANTHERi
PTHR14038, PTHR14038, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07001, BAT2_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F6PKE2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDRLGQITK GKDGKSKYST LSLFDKYKGK SVEAIRSTVI PRHGLQSLGK
60 70 80 90 100
VATARRMPPP ANLPSLKSEN KGNDPNIIIV PKDGTGWANK QDQPDQKSSS
110 120 130 140 150
VTVAQPQESL LQPGLQKSVS NLQKPTQSIS QESTNSVPGG PKSWAQLNGK
160 170 180 190 200
PVGQEGGSRG SSRLLSFSPE EFPTLKAAGE QDKVGKEKGV LDLSYGPGPS
210 220 230 240 250
LRPQNVTSWR EGGGRNITSA TSLTASPTEP GSKNSSTGDG APSSTCTSDS
260 270 280 290 300
KEPSLRPAQP VRKGASQFMG NVYHPPTYHD MLPAFMCSQQ SPETQGTVER
310 320 330 340 350
GSFPLPQLRL EPRVPFRQYQ MNDQDGKENR MGMSRPTRPL RQLGERAPRP
360 370 380 390 400
TIINAENLKG LDELDIDADD GWAGLHDEVD YSEKLKFSED EEEEEALKDG
410 420 430 440 450
RQKWNNWDPR RQRQLSLSSA DSTDVKHTLD EGKNWSESMG MSRAIRKVLE
460 470 480 490 500
PQPPSRKLNS WTPTPDYQKS SMSNMLRQQS MEDKEDKFPP RQKFVPSEIS
510 520 530 540 550
EAVERARRRR EEEERRAREE RLAACAAKLK QLDQKCKQAQ KASEAQKHID
560 570 580 590 600
SEVPRSPAAA TEKSSPQDNG HALPKPELHA QESPTTYNEE ETVIPPAVTQ
610 620 630 640 650
SSSDEELRES TSPAQEFNKY QKSLPPRFQR QQQQQQEQLY KLQHWQQQQQ
660 670 680 690 700
VYPPPSHSHP QRTFYPHHPQ MLGFDPRWMM MPPYMDPRIP PARTPVDFYP
710 720 730 740 750
SALHPSGMMK PMMPQDSING TGCHSEEPNC PPPVQERKTA SMEPAPVWSQ
760 770 780 790 800
ESYVTIPNKG YTLSNPKQND TTLTIEGVHA RSPEEALPGG LGNSNSGNNH
810 820 830 840 850
STYNLERVAH NNSDITESPG KKTEKESKLA VQRAGEKGEA LPQFDLSYGN
860 870 880 890 900
TIIDNRVSNP GEESEVGSMV SEGFIEVLTK KQRRLMEEER RKKEQAAQAP
910 920 930 940 950
TKGRTLSSRI PPRFAKKHNN LCLEQGDGAV PSSSLGTEIW ENNSQALPVQ
960 970 980 990 1000
STSSDSWSKA VNAFTSTESS STEQGFKSSQ GDSGIDLSAE SRESSATSSQ
1010 1020 1030 1040 1050
RSSPYGTLKP EEMNGPGLAE PKSDCQKEQA QKQSEKKDSE QGSGQNKEHK
1060 1070 1080 1090 1100
PGPIGNERSL KNRKGSEGGE RLEGNVPPVN GVEIHVDSVL PVPPIEFGVN
1110 1120 1130 1140 1150
PKDSDFSLPP GSASSTSANP VVKLQDALAS NAGLTQSIPI LRRDHHLQRG
1160 1170 1180 1190 1200
MSLNPMSFPT ADLTLKMESA RKAWENSPSL PEQNSPGGAG SGIQPPSSVG
1210 1220 1230 1240 1250
ASSGVNYSSF GGVSMPPMPV ASVAPSSIPG NHIPPLYLDG HVFASQPRLV
1260 1270 1280 1290 1300
PQTIPQQQSY QQAAQQIPIS LHTSLQAQAQ LGLRGGLPVS QSQEIYSSIQ
1310 1320 1330 1340 1350
PFRSQVYMHP SLSQPSTMVL TGGTALKPPY SAFPGMQPLE MVKTQSGSPY
1360 1370 1380 1390 1400
QPMNGSQALV YESQLNQAAG MGASQMMDSQ LTQLTMPLPR YGSGQQPLIL
1410 1420 1430 1440 1450
PQSIQLPQGQ NLSVGAPRRI LPPGSQPSVL PTNRESSQME MKGFHFADGK
1460 1470 1480 1490 1500
QNIPSGGSVP SPQTYRPSSA SPSGKPSGPA VNMGSVQGHY VQQAKRVDEN
1510 1520 1530
KPSLGTVKLQ ESASATQMKR TGAIKPQAVK VEESKA
Length:1,536
Mass (Da):167,560
Last modified:December 11, 2019 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E1274C30DD053A5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F8HDU7A0A5F8HDU7_MONDO
Proline rich coiled-coil 2B
PRRC2B
265Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMODT00000015846; ENSMODP00000015558; ENSMODG00000012428

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi13616.ENSMODP00000015558

Genome annotation databases

EnsembliENSMODT00000015846; ENSMODP00000015558; ENSMODG00000012428

Phylogenomic databases

eggNOGiKOG4817, Eukaryota
GeneTreeiENSGT00950000183161
HOGENOMiCLU_001247_0_0_1
InParanoidiF6PKE2
OrthoDBi17901at2759
TreeFamiTF328738

Gene expression databases

BgeeiENSMODG00000012428, Expressed in spermatid and 21 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR009738, BAT2_N
IPR033184, PRRC2
PANTHERiPTHR14038, PTHR14038, 2 hits
PfamiView protein in Pfam
PF07001, BAT2_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6PKE2_MONDO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6PKE2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: December 11, 2019
Last modified: June 2, 2021
This is version 46 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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