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Entry version 34 (07 Oct 2020)
Sequence version 1 (20 Jan 2016)
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Protein
Submitted name:

Rho GTPase-activating protein 12a

Gene

arhgap12a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rho GTPase-activating protein 12aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:arhgap12aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-050809-38, arhgap12a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6P057

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F6P057, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000122140

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 70SH3InterPro annotationAdd BLAST63
Domaini253 – 280WWInterPro annotationAdd BLAST28
Domaini342 – 369WWInterPro annotationAdd BLAST28
Domaini457 – 559PHInterPro annotationAdd BLAST103
Domaini640 – 829Rho-GAPInterPro annotationAdd BLAST190

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni71 – 323DisorderedSequence analysisAdd BLAST253
Regioni374 – 400DisorderedSequence analysisAdd BLAST27
Regioni569 – 606DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi96 – 111PolarSequence analysisAdd BLAST16
Compositional biasi154 – 198PolyampholyteSequence analysisAdd BLAST45
Compositional biasi199 – 250PolarSequence analysisAdd BLAST52
Compositional biasi274 – 298PolyampholyteSequence analysisAdd BLAST25
Compositional biasi299 – 317PolarSequence analysisAdd BLAST19
Compositional biasi386 – 400PolyampholyteSequence analysisAdd BLAST15
Compositional biasi575 – 606PolyampholyteSequence analysisAdd BLAST32

Keywords - Domaini

SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1450, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182860

KEGG Orthology (KO)

More...
KOi
K20636

Database of Orthologous Groups

More...
OrthoDBi
1300981at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
F6P057

TreeFam database of animal gene trees

More...
TreeFami
TF329345

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12070, SH3_ARHGAP12, 1 hit
cd00201, WW, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035491, ARHGAP12_SH3
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR001202, WW_dom
IPR036020, WW_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169, PH, 1 hit
PF00620, RhoGAP, 1 hit
PF14604, SH3_9, 1 hit
PF00397, WW, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit
SM00324, RhoGAP, 1 hit
SM00326, SH3, 1 hit
SM00456, WW, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit
SSF50044, SSF50044, 1 hit
SSF51045, SSF51045, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS50238, RHOGAP, 1 hit
PS50002, SH3, 1 hit
PS50020, WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

F6P057-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADRSIAPGQ TYIEVEYDYD YKSKDRLITI KHGESYLLVK KTNDDWWQVR
60 70 80 90 100
KDDASKPFYV PAQYVREVRR ALMPPPKPLN IAGRGGPAPN RPSALEIQRP
110 120 130 140 150
NDNKKSPCPS PSSTALLPPR DDRGSPVSPT RHLPPAQMNT FPGSLPCFRA
160 170 180 190 200
ESPGSKLDGE RDKDKDSERK DRGEKAAVQE ELAEEGGDSD KNRIDSESGD
210 220 230 240 250
ELSSGSTDNL QSLGSGQGRP DSPVYTNLQE MKISQSSTPP LPSSSPIHTN
260 270 280 290 300
GDWETHKDQN GRHYYYNRST QERTWKPPRA RDSLPRKEEK HDMTDTEVLS
310 320 330 340 350
SEENCLSSQS DSQYGSPPRG WSEEMDEHGH TLYVCDYTNE KWLRHTDERG
360 370 380 390 400
RLYYYSADGS RSEWELPKIG LKSQSNHTPL MPGDLHKTRS LDRRLPDPIP
410 420 430 440 450
ISRTQRHSIY SHETNDKLKQ KFVKVRQSFL PRRKTTLRSH PYFPQPSEKC
460 470 480 490 500
ATLNMTKITE HGKKVRKNWT SYWTVLQGSL LIFNKGQGGG SGWFGRDQKS
510 520 530 540 550
SVEYSVDLKG GSVDWASKDK SSKKHVLELK TRQGTELLLQ SDSDGLVNDW
560 570 580 590 600
HKALTEAIHT YMWESDEAIE EDMPESPENE KHDKEKDRKN SKKARDIKKT
610 620 630 640 650
ASMDNAEQKK KNKLVVLLLG RPTLQAVKDK GYIKDQVFGC SLSSLCQREN
660 670 680 690 700
STVPRFVWLC IEQVEKNGLG VDGLYRVSGN LAIIQKLRFA VNHEEKIDLG
710 720 730 740 750
DSKWEDIHVT TGALKMFFRE LPEPLFTYTF FSDFISAIKM PDYKQKVQTV
760 770 780 790 800
KDLMKKLPRP NHDTIQVLFK HLKKVIQHVD ENRMTTQSVA IVFGPTLLRP
810 820 830
EIETANMAVH MVYQNQIVEL ILMEYDTIFG R
Length:831
Mass (Da):94,966
Last modified:January 20, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F7796B4C39ED47E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1QY39F1QY39_DANRE
Rho GTPase-activating protein 12a
arhgap12a
488Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B0UYK0B0UYK0_DANRE
Rho GTPase-activating protein 12a
arhgap12a
260Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR457482 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001119879.1, NM_001126407.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000142804; ENSDARP00000122140; ENSDARG00000008548

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
563267

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:563267

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR457482 Genomic DNA No translation available.
RefSeqiNP_001119879.1, NM_001126407.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000122140

Proteomic databases

PaxDbiF6P057

Genome annotation databases

EnsembliENSDART00000142804; ENSDARP00000122140; ENSDARG00000008548
GeneIDi563267
KEGGidre:563267

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
563267
ZFINiZDB-GENE-050809-38, arhgap12a

Phylogenomic databases

eggNOGiKOG1450, Eukaryota
GeneTreeiENSGT00950000182860
KOiK20636
OrthoDBi1300981at2759
PhylomeDBiF6P057
TreeFamiTF329345

Gene expression databases

ExpressionAtlasiF6P057, baseline

Family and domain databases

CDDicd12070, SH3_ARHGAP12, 1 hit
cd00201, WW, 1 hit
Gene3Di1.10.555.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035491, ARHGAP12_SH3
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR001202, WW_dom
IPR036020, WW_dom_sf
PfamiView protein in Pfam
PF00169, PH, 1 hit
PF00620, RhoGAP, 1 hit
PF14604, SH3_9, 1 hit
PF00397, WW, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00324, RhoGAP, 1 hit
SM00326, SH3, 1 hit
SM00456, WW, 2 hits
SUPFAMiSSF48350, SSF48350, 1 hit
SSF50044, SSF50044, 1 hit
SSF51045, SSF51045, 2 hits
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS50238, RHOGAP, 1 hit
PS50002, SH3, 1 hit
PS50020, WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6P057_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6P057
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 20, 2016
Last sequence update: January 20, 2016
Last modified: October 7, 2020
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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