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Entry version 43 (07 Apr 2021)
Sequence version 1 (14 May 2014)
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Protein
Submitted name:

Alpha-2-macroglobulin-like

Gene

a2ml

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • liver development Source: ZFIN

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitorARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Alpha-2-macroglobulin-likeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:a2mlImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-090212-1, a2ml

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

SecretedARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 30Sequence analysisAdd BLAST30
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500333912231 – 1448Sequence analysisAdd BLAST1418

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
F6NTZ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000056314, Expressed in liver and 19 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F6NTZ9, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000073195

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini465 – 615A2M_N_2InterPro annotationAdd BLAST151
Domaini735 – 824A2MInterPro annotationAdd BLAST90
Domaini1347 – 1437A2M_recepInterPro annotationAdd BLAST91

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. [View classification]ARBA annotation

Keywords - Domaini

SignalSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1366, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162996

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001634_0_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
PSHNETR

TreeFam database of animal gene trees

More...
TreeFami
TF313285

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02897, A2M_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR041813, A2M_TED
IPR011626, Alpha-macroglobulin_TED
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR040839, MG4
IPR008930, Terpenoid_cyclase/PrenylTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF17789, MG4, 1 hit
PF07678, TED_complement, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F6NTZ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
XWTLVIMALN VSCCWKGLLL NFFLFVCVNG QAAEPSFMVT FPAVIESGSE
60 70 80 90 100
AKLCASLLKP NESLVMNIYL VHGNQSTLLL QENAEQEFHR CFNFKAPLAE
110 120 130 140 150
AESVQKIKVE LQGESFKMTE ERKVMFKSYD PLTFIQTDKP IYMPGQIVNF
160 170 180 190 200
RVVTMDTNFA PVDQQYSIIV LEDSQDNRIG QWTNVSSTRW ILQRSYELNP
210 220 230 240 250
ECREGAYKLK AFIGERMSSH YFQVKKYVLP KFEVTVKKPK TVSVVEEELL
260 270 280 290 300
IEVCAKYTYG QPVPGKSWVK VCRNPLPYII FFPLCLEETL EITKTGCAIH
310 320 330 340 350
NFGLSMILNS TLKDNLKDSL HVEAVVTEEG TEITMTKSES VHLTYEIGKI
360 370 380 390 400
TLIDLPKTYE PGSVIEGKIK LSDFKDAPIP NKEVYLLEGE NWSSKLLLNL
410 420 430 440 450
TTDSDGLASF SLNTSSLSKK DISLIANVYP DTRYYGYKTP YFSTDKKTVQ
460 470 480 490 500
LFRIATVYSP TLSELIIEDI EQPLKCGTEI TATVKYYFVG ETVEDFSTDI
510 520 530 540 550
VYMVLSRGVI VHHGFEKVEV KSSSNGLASG TMSFKLSVGA DVAPVVQILA
560 570 580 590 600
YCVLPSENVI AANKRLDTEK CFGNKVSLQF SPAKAVPGEK NTLQLSAQPG
610 620 630 640 650
SLCGLSAVDQ SVLILESGKR LDADKIFNLL PVQSVSYYPY SVEDEQACLY
660 670 680 690 700
VRPRRSVLTD NTYETLKSVG LKMATNLAVR VPDCLSYRGL TYHKNLVMYP
710 720 730 740 750
DHRPVPVMFA LGMAGVDGPV GNSPSVTIRT VFPETWIWEL AEVGDSGSAE
760 770 780 790 800
VPVTVPDTIT TWETEAFCLS STGLGLAPPA QLTVFQPFFL ELSLPYSIIR
810 820 830 840 850
GEIFELKATV FNYLSKCIMV KVSPAPSSDY TLKASSDDQY SSCLCANGRK
860 870 880 890 900
TFKWILTPSV LGVVNVTVSA EAEASQTVCD NEIVSVPERG RIDIVTRSLL
910 920 930 940 950
VQAEGIEKTE TNSWLLCPKG DSLSEKVDLT LPKDVIEGSA KSSVSVIGDI
960 970 980 990 1000
LGRALQNLHG LLRMPYGCGE QNMAVLSPNI YILQYLENTK QLTSAIREKA
1010 1020 1030 1040 1050
SSFLKSGYQR QLNYKHFDGA YSTFGYGDGN TWLTAFVLRS FGKAQKYTFI
1060 1070 1080 1090 1100
DPQIIQSAKD WLISRRDSDG CFIQQGRLFN NRMKGGVNDN VTMTAYITAS
1110 1120 1130 1140 1150
LLELETPVTD PVITKGLSCL RSVIEEVKNT YTTALLAYTF SLARDTNTRQ
1160 1170 1180 1190 1200
QLFNKLEDLA ISDGPLVHWS RSASADDSAS LDVEISSYVL LAVLTADSLT
1210 1220 1230 1240 1250
TADLGFANRI VSWLVKQQNA YGGFSSTQDT VVALQALSLY ATKVFSSDGS
1260 1270 1280 1290 1300
STVTVQSAGD SHHFDVNQDN KLLYQEKQLA NVPGKYSIEV KGSACVSVQI
1310 1320 1330 1340 1350
AQFYNIPTPT EAKTLSIDAK IEGDCEALGQ NFIFDFTVKY DGPEEKTNMA
1360 1370 1380 1390 1400
IVDIKLLSGF TADTSALGTS SGTYVSLVER VDSKDDHVIV YLKEISKNVA
1410 1420 1430 1440
MNYQIQMKQV LQVKNLKPAV VKVYDYYQTS DQSEIEYSFH CEALKNIN
Length:1,448
Mass (Da):160,533
Last modified:May 14, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA94E02FF3E6B8496
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4IDD1A0A0R4IDD1_DANRE
Alpha-2-macroglobulin-like
a2ml
1,442Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CR626907 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000078734; ENSDARP00000073195; ENSDARG00000056314

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR626907 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073195

Proteomic databases

PaxDbiF6NTZ9

Genome annotation databases

EnsembliENSDART00000078734; ENSDARP00000073195; ENSDARG00000056314

Organism-specific databases

ZFINiZDB-GENE-090212-1, a2ml

Phylogenomic databases

eggNOGiKOG1366, Eukaryota
GeneTreeiENSGT00940000162996
HOGENOMiCLU_001634_0_1_1
OMAiPSHNETR
TreeFamiTF313285

Gene expression databases

BgeeiENSDARG00000056314, Expressed in liver and 19 other tissues
ExpressionAtlasiF6NTZ9, baseline

Family and domain databases

CDDicd02897, A2M_2, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR041813, A2M_TED
IPR011626, Alpha-macroglobulin_TED
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR040839, MG4
IPR008930, Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF17789, MG4, 1 hit
PF07678, TED_complement, 1 hit
SMARTiView protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit
SUPFAMiSSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF6NTZ9_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F6NTZ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 14, 2014
Last sequence update: May 14, 2014
Last modified: April 7, 2021
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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