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Protein
Submitted name:

Adenosine deaminase 2b

Gene

ada2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

  • adenosine deaminase activity Source: GO_Central
  • growth factor activity Source: GO_Central

GO - Biological processi

  • adenosine catabolic process Source: GO_Central
  • blood vessel endothelial cell differentiation Source: ZFIN
  • inosine biosynthetic process Source: GO_Central
  • neutrophil differentiation Source: ZFIN

Enzyme and pathway databases

ReactomeiR-DRE-5683826 Surfactant metabolism
R-DRE-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Submitted name:
Adenosine deaminase 2bImported
Gene namesi
Name:ada2bImported
Synonyms:cecr1bImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 4

Organism-specific databases

ZFINiZDB-GENE-041210-77 ada2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500334032527 – 501Sequence analysisAdd BLAST475

Proteomic databases

PaxDbiF6NKG5

Expressioni

Gene expression databases

BgeeiENSDARG00000015623 Expressed in 16 organ(s), highest expression level in spleen

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000118045

Structurei

3D structure databases

ProteinModelPortaliF6NKG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 97A_deaminase_NInterPro annotationAdd BLAST67
Domaini260 – 484A_deaminaseInterPro annotationAdd BLAST225

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1097 Eukaryota
COG1816 LUCA
GeneTreeiENSGT00390000012118
KOiK19572
OMAiAGQTNWY
OrthoDBiEOG091G0CQY
TreeFamiTF324524

Family and domain databases

InterProiView protein in InterPro
IPR001365 A/AMP_deaminase_dom
IPR013659 A_deaminase_N
IPR006331 ADGF
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF00962 A_deaminase, 1 hit
PF08451 A_deaminase_N, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR01431 adm_rel, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

F6NKG5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSISLKDVS AAVMVVLLVC VSECKSMPDP RQREQMLQQE LLQQIGGNME
60 70 80 90 100
LNEAEKRMDS LLYMLKMKEI TLSPFPPANH FFKVRHIIQQ SPIFKLLQKM
110 120 130 140 150
PKGAALHIHN SAMVSVDWLL NATYRPNCYI CFTWDGSVRF MFSTSTPFPR
160 170 180 190 200
WGCSFWKRLD ILRASLGDVT SFDNSLMRNL TLFTEDPETS YPTQDYIWKR
210 220 230 240 250
FEKIFIALSG LITYAPVLKD HIYQGLKELY EDNIMYVELR IGQAKAYELD
260 270 280 290 300
GTTHDRAWTI EVYRNITEQF RANHPDFIGT RVILSAHRSS SVSRVKQAVQ
310 320 330 340 350
EAIEMQRKYP EIVAGFDLVG REDTGGSIWY FRDALSLPSE SQLPYFFHAG
360 370 380 390 400
ETDLDGTDVD RNVLDALLFN TSRIGHGFAI VHHPVAKQLS RSRRVAVELC
410 420 430 440 450
PISNQVLKLV SDLRNHPAAV LMSDGHPMVV SSDDPSLFGT TGLSYDFYEV
460 470 480 490 500
FVGIGGLSAN LGTLKELAIN SIRYSSLSAQ LQDKAMTVWQ EKWNTFIAEN

S
Length:501
Mass (Da):56,910
Last modified:February 22, 2012 - v1
Checksum:i4112DA838B4EBE22
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8QQB2A0A2R8QQB2_DANRE
Adenosine deaminase 2b
ada2b
357Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323558 Genomic DNA No translation available.
RefSeqiXP_687719.2, XM_682627.3

Genome annotation databases

EnsembliENSDART00000144048; ENSDARP00000118045; ENSDARG00000015623
GeneIDi559295
KEGGidre:559295

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323558 Genomic DNA No translation available.
RefSeqiXP_687719.2, XM_682627.3

3D structure databases

ProteinModelPortaliF6NKG5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000118045

Proteomic databases

PaxDbiF6NKG5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000144048; ENSDARP00000118045; ENSDARG00000015623
GeneIDi559295
KEGGidre:559295

Organism-specific databases

CTDi559295
ZFINiZDB-GENE-041210-77 ada2b

Phylogenomic databases

eggNOGiKOG1097 Eukaryota
COG1816 LUCA
GeneTreeiENSGT00390000012118
KOiK19572
OMAiAGQTNWY
OrthoDBiEOG091G0CQY
TreeFamiTF324524

Enzyme and pathway databases

ReactomeiR-DRE-5683826 Surfactant metabolism
R-DRE-6798695 Neutrophil degranulation

Gene expression databases

BgeeiENSDARG00000015623 Expressed in 16 organ(s), highest expression level in spleen

Family and domain databases

InterProiView protein in InterPro
IPR001365 A/AMP_deaminase_dom
IPR013659 A_deaminase_N
IPR006331 ADGF
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF00962 A_deaminase, 1 hit
PF08451 A_deaminase_N, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR01431 adm_rel, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF6NKG5_DANRE
AccessioniPrimary (citable) accession number: F6NKG5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 22, 2012
Last sequence update: February 22, 2012
Last modified: November 7, 2018
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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