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UniProtKB - F6NK88 (F6NK88_DANRE)
Protein
Zinc finger FYVE domain-containing protein 26
Gene
zfyve26
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.
ARBA annotationGO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- phosphatidylinositol-3-phosphate binding Source: GO_Central
GO - Biological processi
- axonogenesis Source: ZFIN
- double-strand break repair via homologous recombination Source: InterPro
- mitotic cytokinesis Source: InterPro
- oocyte development Source: ZFIN
- regulation of cytokinesis Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger FYVE domain-containing protein 26ARBA annotation |
Gene namesi | Name:zfyve26Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-030131-3286, zfyve26 |
Subcellular locationi
Other locations
- Midbody ARBA annotation
Cytoskeleton
- centrosome Source: GO_Central
Other locations
- midbody Source: GO_Central
Expressioni
Gene expression databases
Bgeei | ENSDARG00000040131, Expressed in intestine and 27 other tissues |
ExpressionAtlasi | F6NK88, baseline |
Interactioni
Subunit structurei
Interacts with AP5Z1, AP5B1, AP5S1 and SPG11.
Interacts with TTC19 and KIF13A.
ARBA annotationProtein-protein interaction databases
STRINGi | 7955.ENSDARP00000115049 |
Structurei
3D structure databases
AlphaFoldDBi | F6NK88 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1825 – 1884 | FYVE-typeInterPro annotationAdd BLAST | 60 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 563 – 586 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 704 – 760 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 848 – 875 | DisorderedSequence analysisAdd BLAST | 28 | |
Regioni | 1258 – 1302 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 1768 – 1821 | DisorderedSequence analysisAdd BLAST | 54 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 563 – 582 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 729 – 743 | Basic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 848 – 863 | Polar residuesSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG1811, Eukaryota |
GeneTreei | ENSGT00920000149143 |
InParanoidi | F6NK88 |
OrthoDBi | 1237900at2759 |
TreeFami | TF324517 |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR028730, ZFYVE26 IPR000306, Znf_FYVE IPR017455, Znf_FYVE-rel IPR011011, Znf_FYVE_PHD IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR46591, PTHR46591, 1 hit |
Pfami | View protein in Pfam PF01363, FYVE, 1 hit |
SMARTi | View protein in SMART SM00064, FYVE, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50178, ZF_FYVE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F6NK88-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHPFGREEET SRRELFGFFR RCLQRGEWEL AAACVSQLGE ARAEDPHSPR
60 70 80 90 100
DIVKAIVTHP YPLRWETVGS PHRLAWYWLQ VLERPTEIKV SVSVKRELEF
110 120 130 140 150
LLLLEELEDI PQSVLKELHE AFLYSEEVKG KAPGDSASPL SAALLSCLRS
160 170 180 190 200
LLTRQQPRLC HSLISFLSNG DPSRDHTLQD AFIQHLTEQV KVPAKDRNRE
210 220 230 240 250
WVEQVCSVLA LAPWGSDRSG AQLEPLWEGL WAAREGLMTE ERILGCLLRP
260 270 280 290 300
QSQALLMAYS STALRLLKDK LLAEAPHTQV DLPDLERVML GLCCHKDKRL
310 320 330 340 350
AWKAIYFECL SSGKHFLEQV LLTGLDLIKR EEFSKLETLL HSEFQPLSRL
360 370 380 390 400
LLLLGWMHCQ SLESAKTLLT VLHHRQPQSN DSALSDLACT LSCQLGVLEW
410 420 430 440 450
CTQNNPGISH DALLSHLHML DHHSALYVLH CLTPLAKFEE HKVLELLQRT
460 470 480 490 500
GDPSQVDSPS SSVQRNITLF RGFCAMKYAL YAISVNARTH AHTGSLDCEP
510 520 530 540 550
LHELQTEAAQ EDETAEGCSN LFQHYLSECQ LYLEAVPALF RLELLENIFS
560 570 580 590 600
LLFLSDSDFT QQTSTATETQ PYTNTETSKP KSTKEVNTAE HFLKAENEGE
610 620 630 640 650
RMDELNQINP QLGHLTSGCR GFLVDLNVME GILRLVREGL EGVCGVGQED
660 670 680 690 700
GRALGADVEL AESLGCSVTA ETFSARLQRL SKYTAEAQWR LQIVTSNHGN
710 720 730 740 750
GNDGLYLPSP LPSPALPLKR QGSGSSGTSS RRRRKHHRHR SERHVSSERQ
760 770 780 790 800
NGEVSTSTSD GGVCVSVVCR GTETCPCGGS HSWLVPAMLS PPESLLIACI
810 820 830 840 850
RRGNYIEAQQ VIAMYGLENS ECAGELVFMD RYREVLIELA QVEQKIESQS
860 870 880 890 900
LSTSSSSSEG LGTLGATPAG RTRMGSSSRL TLKSIGSAAA AGMAFYSISD
910 920 930 940 950
VADRLMSTPS RPIPCLEDSY WLSQCTIDSP DFVRPLVEEL SPAAMAAFDL
960 970 980 990 1000
SCCQCQLWKT SRQLLETAER RLSSFLEARG VRVDPKVPHA NGIRGFPSVL
1010 1020 1030 1040 1050
QQISKILNKT STNKGMSKTD CNGEENAVCS PFGCSAQEVL LSCHSTLTEE
1060 1070 1080 1090 1100
SITIQQNLNQ RLEVTLQTLS SATNTSVDSL VGSNLLTALA EQAALKQSEL
1110 1120 1130 1140 1150
DCHPVRTAMK QLLQYLDQLC PLVPDGAPDR PDYIRSFFDY VNVLASVLVR
1160 1170 1180 1190 1200
SLGSEDQSTV VKLGNPLLLL LQSPAQLLSH LLFDRQVSPD RVLSLLQQER
1210 1220 1230 1240 1250
LRLSVQQVVV QRCCETLPLW DSRAVNFSQR VSGLNGGAFC PASIASILQQ
1260 1270 1280 1290 1300
YAQDCSPSLD LSDPTTTSDP SSESEVSVED VSAASTSLST SPPSPSSSSP
1310 1320 1330 1340 1350
SSSFLLTPSA LSFLKSRSPL VAALACLSAS RGGVTRVTSS GWSGLPSYFR
1360 1370 1380 1390 1400
GSGRKEAVLD GEQISREGEA LLKNFPILRM YLRTMAEPVL GVSLEADEGL
1410 1420 1430 1440 1450
GVALCGKPVV GMLFSGLQGN AAQAMAAEAF QQALNNGDLN RALDLLELYA
1460 1470 1480 1490 1500
QPCSQEGALR DKLLAFTALQ ESSSAEQLFR VRDWELRGRV VLQGLDRWPL
1510 1520 1530 1540 1550
QQCLDLLHFC LSDQNTKDPL REQLQQRKQE LDMYQRMLRL QPSLPWETWQ
1560 1570 1580 1590 1600
ELREESTKNP ESVFSQMLEA REFELCAQWV QLYSVSDQSG MQLQTEHLLY
1610 1620 1630 1640 1650
LLEHNHTEEA FQLLEALSDS MGLEVSERAL DRRPGLAACH FLSDYLTLHF
1660 1670 1680 1690 1700
QSQMTPARRR HIHALHLGSK VLLTLPEASR QDYFSLLSDP LLMLEQMLMN
1710 1720 1730 1740 1750
LKVDWAAVAI TTLRSLLLAQ DAGITTQHID TLLADYARKA LDFPYAPREW
1760 1770 1780 1790 1800
SRSDSVISLQ DAFLQCPAQE SCPSSPSHTP PPSTGGTPMQ TPSSERRPSG
1810 1820 1830 1840 1850
KKIRPLATPF TPPEKTPDRK DWIPDHKQHI CMVCQRERFT MFNRRHHCRR
1860 1870 1880 1890 1900
CGRLVCHSCS SKKMAVAGFD EPVRVCDQCY NFFHTDSDEE LEQGEVAGSP
1910 1920 1930 1940 1950
SSIDEVLNGV LSLPEVSRKQ YRLSPNPAEN QQLKSEFYYE QAPSASLCVA
1960 1970 1980 1990 2000
ILTLHSDHAA CGQQLIDHCR SLSRKLTNPE VDARLLTDVM RQLLFSAKLM
2010 2020 2030 2040 2050
FVNAGCTQEP ALCDSYISKV DVLKILVTAN YKYIPSLDDI QETAAVTRLR
2060 2070 2080 2090 2100
NQLLELEYYQ LAVEVSTKSA LDPNGVWQAW AMASLKAGNL SGAREKFVRC
2110 2120 2130 2140 2150
LKAPVDRNQL NHGPRLLQEI IQHLESTVKL TLSQTMDEDI LASLRELEEA
2160 2170 2180 2190 2200
LSDSAPPEGT ESKVQRCNFH QECLFYLFTY GTHLSLISFY LRHDCLKDAL
2210 2220 2230 2240 2250
TYLQNKGCSD DVFLEGIFQP CLERGRLGAL QGLLENLDPT LETWGRYLLS
2260 2270 2280 2290 2300
ACQLLQRRGH YHSLYQLQQF MMDHIRAAMT CIRFFSHGAQ SYLQLGEQQR
2310 2320 2330 2340 2350
WLIRAKEHLR TYLQEQQSRR KSHSSSFRKK MSSTDVSRHI HTIELQLEVT
2360 2370 2380 2390 2400
RFLHRCESSP SKTAVGSTYT GNSAPPTLFG NSPMKVDVAC KVMLGGKNIE
2410 2420 2430 2440 2450
EGFGIAYRVI QDFQLEALAV YIRVGQRLVR QRQYSSVRQL HKCVGESGTA
2460 2470 2480 2490 2500
SKHDCDAIVL SCVSVADKSP ADAKELETLI LECKNPENKI KAYLQCSKLR
2510 2520 2530 2540 2550
AAYLQAVKLK LVKATPLIQE VMRAAESSGD SVMHDICRQW LSEHQEPSSK
QR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1Q533 | F1Q533_DANRE | Zinc finger FYVE domain-containing ... | zfyve26 | 2,551 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX323843 Genomic DNA No translation available. BX470227 Genomic DNA No translation available. |
RefSeqi | XP_003199781.2, XM_003199733.4 |
Genome annotation databases
Ensembli | ENSDART00000140543.3; ENSDARP00000115049.2; ENSDARG00000040131.8 |
GeneIDi | 324565 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX323843 Genomic DNA No translation available. BX470227 Genomic DNA No translation available. |
RefSeqi | XP_003199781.2, XM_003199733.4 |
3D structure databases
AlphaFoldDBi | F6NK88 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000115049 |
Proteomic databases
PaxDbi | F6NK88 |
Genome annotation databases
Ensembli | ENSDART00000140543.3; ENSDARP00000115049.2; ENSDARG00000040131.8 |
GeneIDi | 324565 |
Organism-specific databases
CTDi | 23503 |
ZFINi | ZDB-GENE-030131-3286, zfyve26 |
Phylogenomic databases
eggNOGi | KOG1811, Eukaryota |
GeneTreei | ENSGT00920000149143 |
InParanoidi | F6NK88 |
OrthoDBi | 1237900at2759 |
TreeFami | TF324517 |
Gene expression databases
Bgeei | ENSDARG00000040131, Expressed in intestine and 27 other tissues |
ExpressionAtlasi | F6NK88, baseline |
Family and domain databases
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR028730, ZFYVE26 IPR000306, Znf_FYVE IPR017455, Znf_FYVE-rel IPR011011, Znf_FYVE_PHD IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR46591, PTHR46591, 1 hit |
Pfami | View protein in Pfam PF01363, FYVE, 1 hit |
SMARTi | View protein in SMART SM00064, FYVE, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50178, ZF_FYVE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F6NK88_DANRE | |
Accessioni | F6NK88Primary (citable) accession number: F6NK88 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 21, 2011 |
Last sequence update: | September 21, 2011 | |
Last modified: | May 25, 2022 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |