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Protein
Submitted name:

Phosphatase and tensin-like protein

Gene

PTEN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei124Phosphocysteine intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatase and tensin-like proteinImported
Submitted name:
Phosphatase and tensin-like protein isoform AImported
Gene namesi
Name:PTENImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000171862.9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSG00000171862 Expressed in 205 organ(s), highest expression level in intestine

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 185Phosphatase tensin-typeInterPro annotationAdd BLAST172
Domaini190 – 350C2 tensin-typeInterPro annotationAdd BLAST161

Phylogenomic databases

eggNOGiKOG2283 Eukaryota
COG2453 LUCA
KOiK01110
OMAiREDKYMY
OrthoDBiEOG091G09VG

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR017361 Bifunc_PIno_P3_Pase/Pase_PTEN
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF10409 PTEN_C2, 1 hit
PIRSFiPIRSF038025 PTEN, 1 hit
SMARTiView protein in SMART
SM01326 PTEN_C2, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit

Sequencei

Sequence statusi: Complete.

F6KD01-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI
60 70 80 90 100
DDVVRFLDSK HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL
110 120 130 140 150
IKPFCEDLDQ WLSEDDNHVA AIHCKAGKGR TGVMICAYLL HRGKFLKAQE
160 170 180 190 200
ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY LLKNHLDYRP VALLFHKMMF
210 220 230 240 250
ETIPMFSGGT CNPQFVVCQL KVKIYSSNSG PTRREDKFMY FEFPQPLPVC
260 270 280 290 300
GDIKVEFFHK QNKMLKKDKM FHFWVNTFFI PGPEETSEKV ENGSLCDQEI
310 320 330 340 350
DSICSIERAD NDKEYLVLTL TKNDLDKANK DKANRYFSPN FKVKLYFTKT
360 370 380 390 400
VEEPSNPEAS SSTSVTPDVS DNEPDHYRYS DTTDSDPENE PFDEDQHTQI

TKV
Length:403
Mass (Da):47,166
Last modified:July 27, 2011 - v1
Checksum:i75F97C3DD6802BA9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei403Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM849628 Genomic DNA Translation: ADM26753.1
HM849629 Genomic DNA Translation: ADM26754.1
HM849630 Genomic DNA Translation: ADM26755.1
HM849631 Genomic DNA Translation: ADM26756.1
HM849634 Genomic DNA Translation: ADM26759.1
KJ534922 mRNA Translation: AHW56562.1
RefSeqiNP_000305.3, NM_000314.6
UniGeneiHs.500466
Hs.729457

Genome annotation databases

GeneIDi5728
KEGGihsa:5728

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM849628 Genomic DNA Translation: ADM26753.1
HM849629 Genomic DNA Translation: ADM26754.1
HM849630 Genomic DNA Translation: ADM26755.1
HM849631 Genomic DNA Translation: ADM26756.1
HM849634 Genomic DNA Translation: ADM26759.1
KJ534922 mRNA Translation: AHW56562.1
RefSeqiNP_000305.3, NM_000314.6
UniGeneiHs.500466
Hs.729457

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi5728
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5728
KEGGihsa:5728

Organism-specific databases

CTDi5728
EuPathDBiHostDB:ENSG00000171862.9

Phylogenomic databases

eggNOGiKOG2283 Eukaryota
COG2453 LUCA
KOiK01110
OMAiREDKYMY
OrthoDBiEOG091G09VG

Miscellaneous databases

ChiTaRSiPTEN human
GenomeRNAii5728

Gene expression databases

BgeeiENSG00000171862 Expressed in 205 organ(s), highest expression level in intestine

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR017361 Bifunc_PIno_P3_Pase/Pase_PTEN
IPR000340 Dual-sp_phosphatase_cat-dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR014020 Tensin_C2-dom
IPR029023 Tensin_phosphatase
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF10409 PTEN_C2, 1 hit
PIRSFiPIRSF038025 PTEN, 1 hit
SMARTiView protein in SMART
SM01326 PTEN_C2, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51182 C2_TENSIN, 1 hit
PS51181 PPASE_TENSIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF6KD01_HUMAN
AccessioniPrimary (citable) accession number: F6KD01
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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