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Protein

Argininosuccinate synthase

Gene

argG

Organism
Thermus thermophilus (strain SG0.5JP17-16)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei84CitrullineUniRule annotation1
Binding sitei89CitrullineUniRule annotation1
Binding sitei114ATP; via amide nitrogenUniRule annotation1
Binding sitei116AspartateUniRule annotation1
Binding sitei120AspartateUniRule annotation1
Binding sitei120CitrullineUniRule annotation1
Binding sitei121AspartateUniRule annotation1
Binding sitei124CitrullineUniRule annotation1
Binding sitei173CitrullineUniRule annotation1
Binding sitei182CitrullineUniRule annotation1
Binding sitei258CitrullineUniRule annotation1
Binding sitei270CitrullineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 14ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTHE762633:G1GY5-107-MONOMER
UniPathwayi
UPA00068;UER00113

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotationSAAS annotation (EC:6.3.4.5UniRule annotationSAAS annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Ththe16_0099Imported
OrganismiThermus thermophilus (strain SG0.5JP17-16)Imported
Taxonomic identifieri762633 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciThermalesThermaceaeThermus
Proteomesi
  • UP000009233 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01940
OMAiPAREWGM
OrthoDBiPOG091H01U0

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit

Sequencei

Sequence statusi: Complete.

F6DHT8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIVLAYSGG LDTSIILKWL KETYRAEVIA FTADIGQGEE VEEAREKALR
60 70 80 90 100
TGASKAIALD LKEEFVRDFV FPMMRAGAVY EGYYLLGTSI ARPLIAKHLV
110 120 130 140 150
RIAEEEGAEA IAHGATGKGN DQVRFELTAY ALKPDIKVIA PWREWSFQGR
160 170 180 190 200
KEMIAYAEAH GIPVPVTQEK PYSMDPNLLH ISYEGGVLED PWAEPPKGMF
210 220 230 240 250
RMTQDPEEAP DAPEYVEVEF FEGDPVAVNG ERLSPAALLQ RLNEIGGRHG
260 270 280 290 300
VGRVDIVENR FVGMKSRGVY ETPGGTILYH ARRAVESLTL DREVLHQRDM
310 320 330 340 350
LSPKYAELVY YGFWYAPERE ALQAYFDHVA RSVTGVARLK LYKGNVYVVG
360 370 380 390 400
RKAAKSLYQK DLVSFDELGG YDQKDAEGFI KIQALRLRVR ALVEREGHGA
Length:400
Mass (Da):44,830
Last modified:July 27, 2011 - v1
Checksum:i4141E9E81CF46BDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002777 Genomic DNA Translation: AEG32537.1
RefSeqiWP_014509741.1, NC_017272.1

Genome annotation databases

EnsemblBacteriaiAEG32537; AEG32537; Ththe16_0099
KEGGitts:Ththe16_0099
PATRICifig|762633.3.peg.100

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002777 Genomic DNA Translation: AEG32537.1
RefSeqiWP_014509741.1, NC_017272.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEG32537; AEG32537; Ththe16_0099
KEGGitts:Ththe16_0099
PATRICifig|762633.3.peg.100

Phylogenomic databases

KOiK01940
OMAiPAREWGM
OrthoDBiPOG091H01U0

Enzyme and pathway databases

UniPathwayi
UPA00068;UER00113

BioCyciTTHE762633:G1GY5-107-MONOMER

Family and domain databases

CDDicd01999 Argininosuccinate_Synthase, 1 hit
Gene3Di3.40.50.620, 1 hit
3.90.1260.10, 1 hit
HAMAPiMF_00005 Arg_succ_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001518 Arginosuc_synth
IPR018223 Arginosuc_synth_CS
IPR023434 Arginosuc_synth_type_1_subfam
IPR024074 AS_cat/multimer_dom_body
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR11587 PTHR11587, 1 hit
PfamiView protein in Pfam
PF00764 Arginosuc_synth, 1 hit
TIGRFAMsiTIGR00032 argG, 1 hit
PROSITEiView protein in PROSITE
PS00564 ARGININOSUCCIN_SYN_1, 1 hit
PS00565 ARGININOSUCCIN_SYN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF6DHT8_THETG
AccessioniPrimary (citable) accession number: F6DHT8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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