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Protein

DNA ligase

Gene

lig

Organism
Methanobacterium paludis (strain DSM 25820 / JCM 18151 / SWAN1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei256ATPUniRule annotation1
Active sitei258N6-AMP-lysine intermediateUniRule annotation1
Binding sitei263ATPUniRule annotation1
Binding sitei278ATPUniRule annotation1
Binding sitei308ATPUniRule annotation1
Binding sitei347ATPUniRule annotation1
Binding sitei424ATPUniRule annotation1
Binding sitei430ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:MSWAN_0175Imported
OrganismiMethanobacterium paludis (strain DSM 25820 / JCM 18151 / SWAN1)Imported
Taxonomic identifieri868131 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobacterium
Proteomesi
  • UP000009231 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi868131.MSWAN_0175

Structurei

3D structure databases

ProteinModelPortaliF6D1J3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini335 – 465DNA_LIGASE_A3InterPro annotationAdd BLAST131

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
KOiK10747
OMAiWLFEESY
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

F6D1J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSKINMKYM ELVEVYEALD STTKRLEKTS ILAKFFKIMG NEEPELLPIV
60 70 80 90 100
TLMSLGRIFP TWSEEELGLG SKLLMKAISL VAGVGPDDVE NMTRDAGDIG
110 120 130 140 150
LAAETLLKRK QQSTLFARQP LTIEKVHSNL IKITKISGNR AQNKKMEILR
160 170 180 190 200
ELFSSASPKE AKYITRTVLE ELRVGVGEGT IKDAISEAFE VEKTAVERAH
210 220 230 240 250
MLTNDLGLVA EVAKEEGEEG LGKLTLKPGK PVKPMLAQLS PGIKISVEEM
260 270 280 290 300
GWALCETKYD GIRVQIHRLG DDINIFTRRL ENISNAVPEI VEYIRKSLPA
310 320 330 340 350
CDFIVEGEII VTRDGKPISF QYILQRVRRK YDIEKMREKV PLKLYLFDVL
360 370 380 390 400
YYDGPQIDTP FEERRRILES IVTVTEHKLE LSSQVKTTPE EIWKAEDLFT
410 420 430 440 450
ASIKGGHEGI MIKDPHAPYM PGIRGKKMLK LKAVPETLDL VIVGGTYGKG
460 470 480 490 500
RRAHVIGSYL LAVRDENNDF KTLAHAATGL DDNMLIELSR MVEPLIVKKM
510 520 530 540 550
GRKVEITPSI ILEIAYSEIV KSPEYESGYS LRFPVVKRIR EDIGLDDIDT
560
VERVDSMFKE V
Length:561
Mass (Da):63,264
Last modified:July 27, 2011 - v1
Checksum:i4D906B059857AFA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002772 Genomic DNA Translation: AEG17221.1

Genome annotation databases

EnsemblBacteriaiAEG17221; AEG17221; MSWAN_0175
KEGGimew:MSWAN_0175

Similar proteinsi

Entry informationi

Entry nameiF6D1J3_METPW
AccessioniPrimary (citable) accession number: F6D1J3
Entry historyiIntegrated into UniProtKB/TrEMBL: July 27, 2011
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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