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Entry version 23 (05 Jun 2019)
Sequence version 1 (28 Jun 2011)
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Protein

Major capsid protein

Gene

MCP

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Major capsid proteinUniRule annotation
Short name:
MCPUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MCPUniRule annotation
Synonyms:UL86
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri295027 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000938 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Capsid protein, Host nucleus, T=16 icosahedral capsid protein, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004182371 – 1370Major capsid proteinAdd BLAST1370

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
F5HGT1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homomultimer. Makes the hexons and eleven out of twelve pentons.

Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2.

Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus.

Interacts with capsid vertex component 2/CVC2.

Interacts with the small capsomere-interacting protein/SCP.

UniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
F5HGT1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi72 – 77Poly-Ala6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the herpesviridae major capsid protein family.UniRule annotation

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_04016 HSV_MCP, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000912 Herpes_MCP
IPR023233 Herpes_MCP_upper_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03122 Herpes_MCP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00235 HSVCAPSIDMCP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103417 SSF103417, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F5HGT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENWSALELL PKVGIPTDFL THVKTSAGEE MFEALRIYYG DDPERYNIHF
60 70 80 90 100
EAIFGTFCNR LEWVYFLTSG LAAAAHAIKF HDLNKLTTGK MLFHVQVPRV
110 120 130 140 150
ASGAGLPTSR QTTIMVTKYS EKSPITIPFE LSAACLTYLR ETFEGTILDK
160 170 180 190 200
ILNVEAMHTV LRALKNTADA MERGLIHSFL QTLLRKAPPY FVVQTLVENA
210 220 230 240 250
TLARQALNRI QRSNILQSFK AKMLATLFLL NRTRDRDYVL KFLTRLAEAA
260 270 280 290 300
TDSILDNPTT YTTSSGAKIS GVMVSTANVM QIIMSLLSSH ITKETVSAPA
310 320 330 340 350
TYGNFVLSPE NAVTAISYHS ILADFNSYKA HLTSGQPHLP NDSLSQAGAH
360 370 380 390 400
SLTPLSMDVI RLGEKTVIME NLRRVYKNTD TKDPLERNVD LTFFFPVGLY
410 420 430 440 450
LPEDRGYTTV ESKVKLNDTV RNALPTTAYL LNRDRAVQKI DFVDALKTLC
460 470 480 490 500
HPVLHEPAPC LQTFTERGPP SEPAMQRLLE CRFQQEPMGG AARRIPHFYR
510 520 530 540 550
VRREVPRTVN EMKQDFVVTD FYKVGNITLY TELHPFFDFT HCQENSETVA
560 570 580 590 600
LCTPRIVIGN LPDGLAPGPF HELRTWEIME HMRLRPPPDY EETLRLFKTT
610 620 630 640 650
VTSPNYPELC YLVDVLVHGN VDAFLLIRTF VARCIVNMFH TRQLLVFAHS
660 670 680 690 700
YALVTLIAEH LADGALPPQL LFHYRNLVAV LRLVTRISAL PGLNNGQLAE
710 720 730 740 750
EPLSAYVNAL HDHRLWPPFV THLPRNMEGV QVVADRQPLN PANIEARHHG
760 770 780 790 800
VSDVPRLGAM DADEPLFVDD YRATDDEWTL QKVFYLCLMP AMTNNRACGL
810 820 830 840 850
GLNLKTLLVD LFYRPAFLLM PAATAVSTSG TTSKESTSGV TPEDSIAAQR
860 870 880 890 900
QAVGEMLTEL VEDVATDAHT PLLQACRELF LAVQFVGEHV KVLEVRAPLD
910 920 930 940 950
HAQRQGLPDF ISRQHVLYNG CCVVTAPKTL IEYSLPVPFH RFYSNPTICA
960 970 980 990 1000
ALSDDIKRYV TEFPHYHRHD GGFPLPTAFA HEYHNWLRSP FSRYSATCPN
1010 1020 1030 1040 1050
VLHSVMTLAA MLYKISPVSL VLQTKAHIHP GFALTAVRTD TFEVDMLLYS
1060 1070 1080 1090 1100
GKSCTSVIIN NPIVTKEERD ISTTYHVTQN INTVDMGLGY TSNTCVAYVN
1110 1120 1130 1140 1150
RVRTDMGVRV QDLFRVFPMN VYRHDEVDRW IRHAAGVERP QLLDTETISM
1160 1170 1180 1190 1200
LTFGSMSERN AAATVHGQKA ACELILTPVT MDVNYFKIPN NPRGRASCML
1210 1220 1230 1240 1250
AVDPYDTEAA TKAIYDHREA DAQTFAATHN PWASQAGCLS DVLYNTRHRE
1260 1270 1280 1290 1300
RLGYNSKFYS PCAQYFNTEE IIAANKTLFK TIDEYLLRAK DCIRGDTDTQ
1310 1320 1330 1340 1350
YVCVEGTEQL IENPCRLTQE ALPILSTTTL ALMETKLKGG AGAFATSETH
1360 1370
FGNYVVGEII PLQQSMLFNS
Length:1,370
Mass (Da):153,872
Last modified:June 28, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5EEFCEE4D7498E8D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY446894 Genomic DNA Translation: AAR31638.1

NCBI Reference Sequences

More...
RefSeqi
YP_081534.1, NC_006273.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3077538

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:3077538

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA Translation: AAR31638.1
RefSeqiYP_081534.1, NC_006273.2

3D structure databases

SMRiF5HGT1
ModBaseiSearch...

Proteomic databases

PRIDEiF5HGT1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3077538
KEGGivg:3077538

Family and domain databases

HAMAPiMF_04016 HSV_MCP, 1 hit
InterProiView protein in InterPro
IPR000912 Herpes_MCP
IPR023233 Herpes_MCP_upper_sf
PfamiView protein in Pfam
PF03122 Herpes_MCP, 1 hit
PRINTSiPR00235 HSVCAPSIDMCP
SUPFAMiSSF103417 SSF103417, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMCP_HCMVM
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F5HGT1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: June 28, 2011
Last modified: June 5, 2019
This is version 23 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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