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Protein

Triplex capsid protein 2

Gene

TRX2

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Structural component of the T=16 icosahedral capsid. The capsid is composed of pentamers and hexamers of major capsid protein/MCP, which are linked together by heterotrimers called triplexes. These triplexes are formed by a single molecule of triplex protein 1/TRX1 and two copies of triplex protein 2/TRX2. Additionally, TRX1 is required for efficient transport of TRX2 to the nucleus, which is the site of capsid assembly.UniRule annotation

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Triplex capsid protein 2UniRule annotation
Gene namesi
Name:TRX2UniRule annotation
Ordered Locus Names:ORF26
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation
  • Host nucleus UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Host nucleus, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004238831 – 305Triplex capsid protein 2Add BLAST305

Proteomic databases

PRIDEiF5HGN8

Interactioni

Subunit structurei

Interacts with TRX1 and major capisd protein/MCP.UniRule annotation

Protein-protein interaction databases

BioGridi1777012, 3 interactors

Structurei

3D structure databases

SMRiF5HGN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae TRX2 protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG090000IF

Family and domain databases

HAMAPiMF_04019 HSV_TRX2, 1 hit
InterProiView protein in InterPro
IPR002690 Herpes_capsid_2
PfamiView protein in Pfam
PF01802 Herpes_V23, 1 hit

Sequencei

Sequence statusi: Complete.

F5HGN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALDKSIVVN FTSRLFADEL AALQSKIGSV LPLGDCHRLQ NIQALGLGCV
60 70 80 90 100
CSRETSPDYI QIMQYLSKCT LAVLEEVRPD SLRLTRMDPS DNLQIKNVYA
110 120 130 140 150
PFFQWDSNTQ LAVLPPFFSR KDSTIVLESN GFDLVFPMVV PQQLGHAILQ
160 170 180 190 200
QLLVYHIYSK ISAGAPDDVN MAELDLYTTN VSFMGRTYRL DVDNTDPRTA
210 220 230 240 250
LRVLDDLSMY LCILSALVPR GCLRLLTALV RHDRHPLTEV FEGVVPDEVT
260 270 280 290 300
RIDLDQLSVP DDITRMRVMF SYLQSLSSIF NLGPRLHVYA YSAETLAASC

WYSPR
Length:305
Mass (Da):34,373
Last modified:June 28, 2011 - v1
Checksum:i5C5D9E83C24902BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA Translation: ABD28877.1
RefSeqiYP_001129379.1, NC_009333.1

Genome annotation databases

GeneIDi4961509
KEGGivg:4961509

Similar proteinsi

Entry informationi

Entry nameiTRX2_HHV8P
AccessioniPrimary (citable) accession number: F5HGN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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