UniProtKB - F5HF68 (VIRF1_HHV8P)
Protein
VIRF-1
Gene
vIRF-1
Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Functioni
Plays a role in the inhibition of host innate response by repressing the expression of interferon-inducible genes and blocking host IRF1- and IRF3-mediated transcription. Blocks the interaction between host IRF3 and CREBBP.3 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 89 – 195 | IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST | 107 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- protein domain specific binding Source: CAFA
- transcription regulatory region sequence-specific DNA binding Source: InterPro
GO - Biological processi
- suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process Source: ParkinsonsUK-UCL
- suppression by virus of host IRF3 activity Source: UniProtKB-KW
- suppression by virus of host protein-protein interaction Source: ParkinsonsUK-UCL
Keywordsi
Biological process | Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion |
Names & Taxonomyi
Protein namesi | Recommended name: VIRF-1 |
Gene namesi | Name:vIRF-1 |
Organismi | Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) |
Taxonomic identifieri | 868565 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Rhadinovirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- host cell cytoplasm Source: ParkinsonsUK-UCL
- host cell nucleus Source: ParkinsonsUK-UCL
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000423778 | 1 – 449 | VIRF-1Add BLAST | 449 |
Proteomic databases
PRIDEi | F5HF68 |
Interactioni
Subunit structurei
Interacts with host IRF3, IRF7, and CREBBP.
1 PublicationGO - Molecular functioni
- protein domain specific binding Source: CAFA
Protein-protein interaction databases
BioGRIDi | 1776967, 18 interactors |
IntActi | F5HF68, 2 interactors |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | F5HF68 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the IRF family.PROSITE-ProRule annotation
Family and domain databases
CDDi | cd00103, IRF, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 2.60.200.10, 1 hit |
InterProi | View protein in InterPro IPR001346, Interferon_reg_fact_DNA-bd_dom IPR019471, Interferon_reg_factor-3 IPR017855, SMAD-like_dom_sf IPR008984, SMAD_FHA_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11949, PTHR11949, 2 hits |
Pfami | View protein in Pfam PF00605, IRF, 1 hit PF10401, IRF-3, 1 hit |
SMARTi | View protein in SMART SM00348, IRF, 1 hit SM01243, IRF-3, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS51507, IRF_2, 1 hit |
i Sequence
Sequence statusi: Complete.
F5HF68-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPGQRPNPF GAPGAIPKKP CLSQGSPGTS GSGAPCDEPS RSESPGEGPS
60 70 80 90 100
GTGGSAAAGD ITRQAVVAAI TEWSRTRQLR ISTGASEGKA SIKDWIVCQV
110 120 130 140 150
NSGKFPGVEW EDEERTRFRI PVTPLADPCF EWRRDGELGV VYIRERGNMP
160 170 180 190 200
VDASFKGTRG RRRMLAALRR TRGLQEIGKG ISQDGHHFLV FRVRKPEEEQ
210 220 230 240 250
CVECGVVAGA VHDFNNMARL LQEGFFSPGQ CLPGEIVTPV PSCTTAEGQE
260 270 280 290 300
AVIDWGRLFI RMYYNGEQVH ELLTTSQSGC RISSALRRDP AVHYCAVGSP
310 320 330 340 350
GQVWLPNVPN LACEIAKREL CDTLDACAKG ILLTSSCNGI FCVCYHNGPV
360 370 380 390 400
HFIGNTVPPD SGPLLLPQGK PTRIFNPNTF LVGLANSPLP APSHVTCPLV
410 420 430 440
KLWLGKPVAV GKLEPHAPSP RDFAARCSNF SDACVVLEIM PKPLWDAMQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF148805 Genomic DNA Translation: ABD28909.1 |
RefSeqi | YP_001129411.1, NC_009333.1 |
Genome annotation databases
GeneIDi | 4961464 |
KEGGi | vg:4961464 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF148805 Genomic DNA Translation: ABD28909.1 |
RefSeqi | YP_001129411.1, NC_009333.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4HLY | X-ray | 1.48 | A/B | 88-196 | [»] | |
4YSI | X-ray | 1.02 | B | 44-51 | [»] | |
SMRi | F5HF68 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 1776967, 18 interactors |
IntActi | F5HF68, 2 interactors |
Proteomic databases
PRIDEi | F5HF68 |
Genome annotation databases
GeneIDi | 4961464 |
KEGGi | vg:4961464 |
Family and domain databases
CDDi | cd00103, IRF, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 2.60.200.10, 1 hit |
InterProi | View protein in InterPro IPR001346, Interferon_reg_fact_DNA-bd_dom IPR019471, Interferon_reg_factor-3 IPR017855, SMAD-like_dom_sf IPR008984, SMAD_FHA_dom_sf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11949, PTHR11949, 2 hits |
Pfami | View protein in Pfam PF00605, IRF, 1 hit PF10401, IRF-3, 1 hit |
SMARTi | View protein in SMART SM00348, IRF, 1 hit SM01243, IRF-3, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF49879, SSF49879, 1 hit |
PROSITEi | View protein in PROSITE PS51507, IRF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VIRF1_HHV8P | |
Accessioni | F5HF68Primary (citable) accession number: F5HF68 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 16, 2013 |
Last sequence update: | June 28, 2011 | |
Last modified: | December 2, 2020 | |
This is version 50 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families