vIRF-1

Functionⁱ

Plays a role in the inhibition of host innate response by repressing the expression of interferon-inducible genes and blocking host IRF1- and IRF3-mediated transcription. Blocks the interaction between host IRF3 and CREBBP.3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	89 – 195	IRF tryptophan pentad repeatPROSITE-ProRule annotationAdd BLAST		107

GO - Molecular functionⁱ

DNA binding transcription factor activity Source: InterPro
protein domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 11583620
transcription regulatory region DNA binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 17297443
suppression by virus of host IRF3 activity Source: UniProtKB-KW
suppression by virus of host protein-protein interaction
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 17297443

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Biological process

Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: VIRF-1
Gene namesⁱ	Name:vIRF-1
Organismⁱ	Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifierⁱ	868565 [NCBI]
Taxonomic lineageⁱ	Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Gammaherpesvirinae › Rhadinovirus › Human herpesvirus 8
Virus hostⁱ	Homo sapiens (Human) [TaxID: 9606]
Proteomesⁱ	UP000000942 Componentⁱ: Genome

Subcellular locationⁱ

GO - Cellular componentⁱ

host cell cytoplasm
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 17297443
host cell nucleus
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 17297443

View the complete GO annotation on QuickGO ...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000423778	1 – 449	VIRF-1Add BLAST		449

Proteomic databases

PRIDEⁱ	F5HF68

PRIDEⁱ

F5HF68

Interactionⁱ

Subunit structureⁱ

Interacts with host IRF3, IRF7, and CREBBP.1 Publication

GO - Molecular functionⁱ

protein domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 11583620

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	1776967, 17 interactors
IntActⁱ	F5HF68, 2 interactors

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	92 – 102	Combined sources	11
Beta strandⁱ	109 – 112	Combined sources	4
Beta strandⁱ	117 – 121	Combined sources	5
Helixⁱ	132 – 135	Combined sources	4
Helixⁱ	137 – 145	Combined sources	9
Helixⁱ	153 – 155	Combined sources	3
Beta strandⁱ	156 – 158	Combined sources	3
Helixⁱ	159 – 169	Combined sources	11
Beta strandⁱ	174 – 181	Combined sources	8
Beta strandⁱ	187 – 193	Combined sources	7

3D structure databases

ProteinModelPortalⁱ	F5HF68
SMRⁱ	F5HF68
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the IRF family.PROSITE-ProRule annotation

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K21653

KOⁱ

K21653

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00103 IRF, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit 2.60.200.10, 1 hit
InterProⁱ	View protein in InterPro IPR001346 Interferon_reg_fact_DNA-bd_dom IPR019471 Interferon_reg_factor-3 IPR017855 SMAD-like_dom_sf IPR008984 SMAD_FHA_dom_sf IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR11949 PTHR11949, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00605 IRF, 1 hit PF10401 IRF-3, 1 hit
SMARTⁱ	View protein in SMART SM00348 IRF, 1 hit SM01243 IRF-3, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF49879 SSF49879, 1 hit
PROSITEⁱ	View protein in PROSITE PS51507 IRF_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

F5HF68-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDPGQRPNPF GAPGAIPKKP CLSQGSPGTS GSGAPCDEPS RSESPGEGPS 
        60         70         80         90        100
GTGGSAAAGD ITRQAVVAAI TEWSRTRQLR ISTGASEGKA SIKDWIVCQV 
       110        120        130        140        150
NSGKFPGVEW EDEERTRFRI PVTPLADPCF EWRRDGELGV VYIRERGNMP 
       160        170        180        190        200
VDASFKGTRG RRRMLAALRR TRGLQEIGKG ISQDGHHFLV FRVRKPEEEQ 
       210        220        230        240        250
CVECGVVAGA VHDFNNMARL LQEGFFSPGQ CLPGEIVTPV PSCTTAEGQE 
       260        270        280        290        300
AVIDWGRLFI RMYYNGEQVH ELLTTSQSGC RISSALRRDP AVHYCAVGSP 
       310        320        330        340        350
GQVWLPNVPN LACEIAKREL CDTLDACAKG ILLTSSCNGI FCVCYHNGPV 
       360        370        380        390        400
HFIGNTVPPD SGPLLLPQGK PTRIFNPNTF LVGLANSPLP APSHVTCPLV 
       410        420        430        440 
KLWLGKPVAV GKLEPHAPSP RDFAARCSNF SDACVVLEIM PKPLWDAMQ

Length:449

Mass (Da):48,460

Last modified:June 28, 2011 - v1

Checksum:ⁱ3C6A4E48FD57521A

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF148805 Genomic DNA Translation: ABD28909.1
NCBI Reference Sequences More...RefSeqⁱ	YP_001129411.1, NC_009333.1

Genome annotation databases

GeneIDⁱ	4961464
KEGGⁱ	vg:4961464

Protein	Similar proteins		Species	Score	Length
F5HF68	Latent viral interferon regulatory factor	)	HHV8		449
ORF K9		Human herpesvirus 8 type M		449
VIRF-1 (Fragment)		HHV8		167
VIRF-1 (Fragment)		HHV8		167
VIRF-1 (Fragment)		HHV8		167
+6

Protein	Similar proteins		Species	Score	Length
F5HF68	Latent viral interferon regulatory factor	)	HHV8		449
ORF K9		Human herpesvirus 8 type M		449
VIRF-1 (Fragment)		HHV8		167
VIRF-1 (Fragment)		HHV8		167
VIRF-1 (Fragment)		HHV8		167
+9

Protein	Similar proteins		Species	Score	Length
F5HF68	Latent viral interferon regulatory factor	)	HHV8		449
ORF K9		Human herpesvirus 8 type M		449
VIRF-1 (Fragment)		HHV8		167
VIRF-1 (Fragment)		HHV8		167
VIRF-1 (Fragment)		HHV8		167
+9

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF148805 Genomic DNA Translation: ABD28909.1
NCBI Reference Sequences More...RefSeqⁱ	YP_001129411.1, NC_009333.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4HLY	X-ray	1.48	A/B	88-196	[»]
	4YSI	X-ray	1.02	B	44-51	[»]
ProteinModelPortalⁱ	F5HF68
SMRⁱ	F5HF68
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	1776967, 17 interactors
IntActⁱ	F5HF68, 2 interactors

Proteomic databases

PRIDEⁱ	F5HF68

PRIDEⁱ

F5HF68

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	4961464
KEGGⁱ	vg:4961464

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K21653

KOⁱ

K21653

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00103 IRF, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit 2.60.200.10, 1 hit
InterProⁱ	View protein in InterPro IPR001346 Interferon_reg_fact_DNA-bd_dom IPR019471 Interferon_reg_factor-3 IPR017855 SMAD-like_dom_sf IPR008984 SMAD_FHA_dom_sf IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
PANTHERⁱ	PTHR11949 PTHR11949, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00605 IRF, 1 hit PF10401 IRF-3, 1 hit
SMARTⁱ	View protein in SMART SM00348 IRF, 1 hit SM01243 IRF-3, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit SSF49879 SSF49879, 1 hit
PROSITEⁱ	View protein in PROSITE PS51507 IRF_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VIRF1_HHV8P
Accessionⁱ	F5HF68Primary (citable) accession number: F5HF68
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 16, 2013
	Last sequence update:	June 28, 2011
	Last modified:	July 18, 2018
	This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

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UniProtKB - F5HF68 (VIRF1_HHV8P)

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vIRF-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ