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Protein

Viral FLICE protein

Gene

ORF71

Organism
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the modulation of host signaling pathways by acting as an activator of both the classic and the alternative NF-kappa-B pathways. Thereby, initiates an important range of cellular processes to promote cell survival, proliferation and protection from apoptosis.3 Publications

GO - Biological processi

Keywordsi

Biological processActivation of host NF-kappa-B by virus, Apoptosis, Host-virus interaction, Inhibition of host apoptosis by viral FLIP-like protein, Modulation of host cell apoptosis by virus

Names & Taxonomyi

Protein namesi
Recommended name:
Viral FLICE protein
Short name:
vFLIP
Gene namesi
Name:ORF71
OrganismiHuman herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus)
Taxonomic identifieri868565 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeRhadinovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000942 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004239091 – 188Viral FLICE proteinAdd BLAST188

Proteomic databases

PRIDEiF5HEZ4

Interactioni

Subunit structurei

Interacts with host RIPK1, TRAF2, MAP3K14, IKBKB, and IKBKG. Interacts with host CADM1; this interaction is essential for chronic NF-kappa-B activation.3 Publications

Protein-protein interaction databases

BioGridi1776997, 11 interactors

Structurei

Secondary structure

1188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 12Combined sources9
Helixi16 – 25Combined sources10
Helixi35 – 47Combined sources13
Helixi53 – 63Combined sources11
Helixi66 – 71Combined sources6
Helixi77 – 83Combined sources7
Turni84 – 86Combined sources3
Helixi93 – 104Combined sources12
Helixi107 – 117Combined sources11
Helixi118 – 120Combined sources3
Helixi130 – 139Combined sources10
Helixi149 – 156Combined sources8
Turni157 – 159Combined sources3
Helixi161 – 170Combined sources10

3D structure databases

ProteinModelPortaliF5HEZ4
SMRiF5HEZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 74DED 1PROSITE-ProRule annotationAdd BLAST73
Domaini93 – 169DED 2PROSITE-ProRule annotationAdd BLAST77

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK21662

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR001875 DED_dom
PfamiView protein in Pfam
PF01335 DED, 1 hit
SMARTiView protein in SMART
SM00031 DED, 2 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50168 DED, 2 hits

Sequencei

Sequence statusi: Complete.

F5HEZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYEVLCEV ARKLGTDDRE VVLFLLNVFI PQPTLAQLIG ALRALKEEGR
60 70 80 90 100
LTFPLLAECL FRAGRRDLLR DLLHLDPRFL ERHLAGTMSY FSPYQLTVLH
110 120 130 140 150
VDGELCARDI RSLIFLSKDT IGSRSTPQTF LHWVYCMENL DLLGPTDVDA
160 170 180
LMSMLRSLSR VDLQRQVQTL MGLHLSGPSH SQHYRHTP
Length:188
Mass (Da):21,474
Last modified:June 28, 2011 - v1
Checksum:i37CFE147EAE45371
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148805 Genomic DNA Translation: AAD46498.1
RefSeqiYP_001129429.1, NC_009333.1

Genome annotation databases

GeneIDi4961494
KEGGivg:4961494

Similar proteinsi

Entry informationi

Entry nameiVFLIP_HHV8P
AccessioniPrimary (citable) accession number: F5HEZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 16, 2013
Last sequence update: June 28, 2011
Last modified: July 18, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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