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Entry version 25 (05 Jun 2019)
Sequence version 1 (28 Jun 2011)
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Protein

Major DNA-binding protein

Gene

DBP

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays several crucial roles in viral infection. Participates in the opening of the viral DNA origin to initiate replication by interacting with the origin-binding protein. May disrupt loops, hairpins and other secondary structures present on ssDNA to reduce and eliminate pausing of viral DNA polymerase at specific sites during elongation. Promotes viral DNA recombination by performing strand-transfer, characterized by the ability to transfer a DNA strand from a linear duplex to a complementary single-stranded DNA circle. Can also catalyze the renaturation of complementary single strands. Additionally, reorganizes the host cell nucleus, leading to the formation of prereplicative sites and replication compartments. This process is driven by the protein which can form double-helical filaments in the absence of DNA.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Major DNA-binding proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DBPUniRule annotation
Synonyms:UL57
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri295027 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000938 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • Host nucleus UniRule annotation
  • Note: In the absence of DNA replication, found in the nuclear framework-associated structures (prereplicative sites). As viral DNA replication proceeds, it migrates to globular intranuclear structures (replication compartments).UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004164481 – 1235Major DNA-binding proteinAdd BLAST1235

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
F5HDQ6

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomers. Forms double-helical filaments necessary for the formation of replication compartments within the host nucleus.

Interacts with the origin-binding protein.

Interacts with the helicase primase complex; this interaction stimulates primer synthesis activity of the helicase-primase complex.

Interacts with the DNA polymerase.

Interacts with the alkaline exonuclease; this interaction increases its nuclease processivity.

UniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1232 – 1235Required for nuclear localizationUniRule annotation4

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi846 – 847Required for filament formationUniRule annotation2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi548 – 556Poly-Gly9
Compositional biasi566 – 577Poly-GlyAdd BLAST12
Compositional biasi1173 – 1178Poly-Gly6
Compositional biasi1220 – 1226Poly-Gly7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the herpesviridae major DNA-binding protein family.UniRule annotation

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_04007 HSV_DNBI, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035989 DBP_sf
IPR000635 Viral_ssDNA-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00747 Viral_DNA_bp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF118208 SSF118208, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F5HDQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHEELTALA PVGPAAFLYF SRLNAETQEI LATLSLCDRS SSVVIAPLLA
60 70 80 90 100
GLTVEADFGV SVRTPVLCYD GGVLTKVTSF CPFALYFHHT QGIVAFTEDH
110 120 130 140 150
GDVHRLCEDA RQKYALEAYT PEADRVPTDL AALCAAVGCQ ASETTVHVVV
160 170 180 190 200
GNGLKEFLFA GQLIPCVEEA TTVRLHGGEA VRVPLYPPTL FNSLQLDAEA
210 220 230 240 250
DEVSLDARSA FVEARGLYVP AVSETLFYYV YTSWCQSLRF SEPRVLIEAA
260 270 280 290 300
LRQFVHDSQQ SVKLAPHKRY LGYMSQRLSS LEKDHLMLSD AVVCELAFSF
310 320 330 340 350
ASVFFDSAYQ PAESMLFSEW PLVTNATDHR DLIRALTELK LHLSTHVAAL
360 370 380 390 400
VFSANSVLYQ HRLVYLQSSA RHPSAGGTAS QETLLKAIQF TNGLSAACED
410 420 430 440 450
VYNDARKVLK FQGAPLKDER YGPQHLALVC GTCPQLVSGF VWYLNRVSVY
460 470 480 490 500
NTGLSGSSTL TNHLVGCAAG LCEACGGTCC HTCYQTAFVR VRTRLPVVPK
510 520 530 540 550
QPKKEPCVIT VQSRFLNDVD ILGSFGRRYN VDAKDGGLDG KGDDGVPGGG
560 570 580 590 600
AGGGGGRDVS GGPSDGLGGG RGGGGGGDSG GMMGRGGRML GASVDRTYRL
610 620 630 640 650
NRILDYCRKM RLIDPVTGED TFSAHGKSDF VAVFSALNKF VDDEALGFVS
660 670 680 690 700
EVRLKSSRDE VAGATQAFNL DLNPYAVAFQ PLLAYAYFRS VFYVIQNVAL
710 720 730 740 750
ITATSYIVDN PLTTNLVSKW MTQHFQSIHG AFSTTSSRKG FLFTKQIKSS
760 770 780 790 800
KNSDHDRLLD FRLYAQGTYA VVPMEIKLSR LSVPTLIMVR VKNRPIYRAG
810 820 830 840 850
KGNAGSVFFR RDHVPRRNPA KGCLGFLLYR HHERLFPECG LPCLQFWQKV
860 870 880 890 900
CSNALPKNVP IGDMGEFNAF VKFLVAVTAD YQEHDLLDVA PDCVLSYVES
910 920 930 940 950
RFHNKFLCYY GFKDYIGSLH GLTTRLTTQN HAQFPHVLGA SPRFSSPAEF
960 970 980 990 1000
ALHVKGLKTA GVPAPMAATV ARESLVRSVF EHRSLVTVPV SVEKYAGINN
1010 1020 1030 1040 1050
SKEIYQFGQI GYFSGNGVER SLNVSSMSGQ DYRFMRQRYL LATRLADVLI
1060 1070 1080 1090 1100
KRSRRENVLF DADLIKNRVM LALDAENLDC DPEVMAVYEI LSVREEIPAS
1110 1120 1130 1140 1150
DDVLFFVDGC EALAASLMDK FAALQEQGVE DFSLENLRRV LDADAQRLTD
1160 1170 1180 1190 1200
AAGGEVHDLS ALFAPSGVGA ASGVGGGGLL LGESVAGNSI CFGVPGETGG
1210 1220 1230
GCFLVNAGED EAGGVGGSSG GGGGSGLLPA KRSRL
Length:1,235
Mass (Da):133,849
Last modified:June 28, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19C62999E24AEE8A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY446894 Genomic DNA Translation: AAR31622.1

NCBI Reference Sequences

More...
RefSeqi
YP_081516.1, NC_006273.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3077528

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:3077528

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA Translation: AAR31622.1
RefSeqiYP_081516.1, NC_006273.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiF5HDQ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3077528
KEGGivg:3077528

Family and domain databases

HAMAPiMF_04007 HSV_DNBI, 1 hit
InterProiView protein in InterPro
IPR035989 DBP_sf
IPR000635 Viral_ssDNA-bd
PfamiView protein in Pfam
PF00747 Viral_DNA_bp, 1 hit
SUPFAMiSSF118208 SSF118208, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNBI_HCMVM
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F5HDQ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 28, 2011
Last modified: June 5, 2019
This is version 25 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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