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Protein

Membrane glycoprotein UL144

Gene

UL144

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Activates NF-kappa-B in a tumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6)-dependent manner, causing the up-regulation of the chemokine CCL22.By similarity

GO - Biological processi

Keywordsi

Biological processActivation of host NF-kappa-B by virus, Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane glycoprotein UL144
Alternative name(s):
TNF alpha-like receptor UL144
UL144 protein
Gene namesi
Name:UL144
ORF Names:HHV5wtgp119
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei134 – 154HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000041412021 – 176Membrane glycoprotein UL144Add BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi59 ↔ 71PROSITE-ProRule annotation
Disulfide bondi74 ↔ 87PROSITE-ProRule annotation
Disulfide bondi77 ↔ 95PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiF5HAM0

Interactioni

Subunit structurei

Interacts with host TRIM23; this interaction causes auto-ubiquitination of TRAF6, leading to NF-kappaB activation.By similarity

Protein-protein interaction databases

BioGridi1678024, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliF5HAM0
SMRiF5HAM0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati58 – 95TNFR-CysAdd BLAST38

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK21047
OrthoDBiVOG090000ZU

Family and domain databases

InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
PfamiView protein in Pfam
PF00020 TNFR_c6, 1 hit
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

F5HAM0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPLVMLICF GVILLQLGVT KVCQHNEVQL GNECCPPCGL GQRVTKVCTE
60 70 80 90 100
RTSVTCTPCP NGTYVSGLYN CTDCTQCNVT QVMIRNCTST NNTVCAPKNH
110 120 130 140 150
TYFSTPGVQH HKQRQQNHTA HITVKQGKSG RHTLAWLSLF IFLVGIILLI
160 170
LYLIAAYRSE RCQQCCSIGK IFYRTL
Length:176
Mass (Da):19,629
Last modified:June 28, 2011 - v1
Checksum:iB6726B043F38775B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446894 Genomic DNA Translation: AAR31677.1
RefSeqiYP_081573.1, NC_006273.2

Genome annotation databases

GeneIDi3077471
KEGGivg:3077471

Similar proteinsi

Entry informationi

Entry nameiUL144_HCMVM
AccessioniPrimary (citable) accession number: F5HAM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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