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Entry version 36 (12 Aug 2020)
Sequence version 2 (31 Oct 2012)
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Protein
Submitted name:

Membrane glycoprotein UL8

Gene

UL8

Organism
Human cytomegalovirus (HHV-5) (Human herpesvirus 5)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Membrane glycoprotein UL8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UL8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHuman cytomegalovirus (HHV-5) (Human herpesvirus 5)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10359 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesDuplodnaviriaHeunggongviraePeploviricotaHerviviricetesHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiHomo sapiens (Human) [TaxID: 9606]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000181426 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000153914 Componenti: Genome
  • UP000180881 Componenti: Genome
  • UP000180981 Componenti: Genome
  • UP000151533 Componenti: Genome
  • UP000181469 Componenti: Genome
  • UP000126723 Componenti: Genome
  • UP000181191 Componenti: Genome
  • UP000181462 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei26 – 45HelicalSequence analysisAdd BLAST20
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K21041

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

F5H984-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASDVGSHPL TVTRFRCRVH YVYNKLLILT LFAPVILESV IYVSGPQGGN
60 70 80 90 100
VTLVSNFTSN ISARWFRWDG NDSHLICFYK RGEGLSTPYV GLSLSCAANQ
110 120 130 140 150
ITIFNLTLND SGRYGAEGFT RSGENETFLW YNLTVKPKPL ETTPASNVTT
160 170 180 190 200
IVTTTSTVTD AKSNVTGNVS LAPQLRAVAG FSHQTPLENN THLALGEGFV
210 220 230 240 250
PTMTSSRLSA SENYDGNYEF TETANTTRTN TSDWITLGSS ASLLKSTETA
260 270 280 290 300
VNLSNATTVI PQPVEYPAGG VQYQRAATHY SWMLIIVIIL IIFIIICLRA
310 320
PRKIYHHWKD SKQYGQVFMT DTEL
Length:324
Mass (Da):35,743
Last modified:October 31, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB3675A3C0B79AE2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GU179001 Genomic DNA Translation: ACZ72764.2
KJ361953 Genomic DNA Translation: AHJ83078.1
KM192298 Genomic DNA Translation: AII79455.1
KM192299 Genomic DNA Translation: AII79623.1
KM192300 Genomic DNA Translation: AII79790.1
KM192301 Genomic DNA Translation: AII79947.1
KM192302 Genomic DNA Translation: AII80114.1
KP973623 Genomic DNA Translation: AJY54683.1
KP973624 Genomic DNA Translation: AJY54850.1
KP973625 Genomic DNA Translation: AJY55016.1
KP973626 Genomic DNA Translation: AJY55183.1
KP973627 Genomic DNA Translation: AJY55350.1
KP973628 Genomic DNA Translation: AJY55517.1
KP973629 Genomic DNA Translation: AJY55684.1
KP973630 Genomic DNA Translation: AJY55851.1
KP973631 Genomic DNA Translation: AJY56018.1
KP973632 Genomic DNA Translation: AJY56185.1
KP973633 Genomic DNA Translation: AJY56352.1
KP973634 Genomic DNA Translation: AJY56519.1
KP973635 Genomic DNA Translation: AJY56686.1
KP973636 Genomic DNA Translation: AJY56853.1
KP973637 Genomic DNA Translation: AJY57020.1
KP973638 Genomic DNA Translation: AJY57187.1
KP973639 Genomic DNA Translation: AJY57354.1
KP973640 Genomic DNA Translation: AJY57521.1
KP973641 Genomic DNA Translation: AJY57688.1
KP973642 Genomic DNA Translation: AJY57854.1
KP745681 Genomic DNA Translation: AKI15595.1
KP745691 Genomic DNA Translation: AKI17263.1
KP745697 Genomic DNA Translation: AKI18264.1
KU221090 Genomic DNA Translation: ALT14599.1
KU221091 Genomic DNA Translation: ALT14764.1
KU221092 Genomic DNA Translation: ALT14929.1
KU221093 Genomic DNA Translation: ALT15094.1
KU221094 Genomic DNA Translation: ALT15259.1
KU221095 Genomic DNA Translation: ALT15424.1
KU221096 Genomic DNA Translation: ALT15589.1
KU221097 Genomic DNA Translation: ALT15754.1
KU221098 Genomic DNA Translation: ALT15919.1
KU221099 Genomic DNA Translation: ALT16075.1
KU221100 Genomic DNA Translation: ALT16240.1
KT726946 Genomic DNA Translation: AMJ53546.1
KT726952 Genomic DNA Translation: AMJ54547.1
KY490066 Genomic DNA Translation: AQN70135.1
KY490074 Genomic DNA Translation: AQN71482.1

NCBI Reference Sequences

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RefSeqi
YP_081468.2, NC_006273.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
3077499

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:3077499

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU179001 Genomic DNA Translation: ACZ72764.2
KJ361953 Genomic DNA Translation: AHJ83078.1
KM192298 Genomic DNA Translation: AII79455.1
KM192299 Genomic DNA Translation: AII79623.1
KM192300 Genomic DNA Translation: AII79790.1
KM192301 Genomic DNA Translation: AII79947.1
KM192302 Genomic DNA Translation: AII80114.1
KP973623 Genomic DNA Translation: AJY54683.1
KP973624 Genomic DNA Translation: AJY54850.1
KP973625 Genomic DNA Translation: AJY55016.1
KP973626 Genomic DNA Translation: AJY55183.1
KP973627 Genomic DNA Translation: AJY55350.1
KP973628 Genomic DNA Translation: AJY55517.1
KP973629 Genomic DNA Translation: AJY55684.1
KP973630 Genomic DNA Translation: AJY55851.1
KP973631 Genomic DNA Translation: AJY56018.1
KP973632 Genomic DNA Translation: AJY56185.1
KP973633 Genomic DNA Translation: AJY56352.1
KP973634 Genomic DNA Translation: AJY56519.1
KP973635 Genomic DNA Translation: AJY56686.1
KP973636 Genomic DNA Translation: AJY56853.1
KP973637 Genomic DNA Translation: AJY57020.1
KP973638 Genomic DNA Translation: AJY57187.1
KP973639 Genomic DNA Translation: AJY57354.1
KP973640 Genomic DNA Translation: AJY57521.1
KP973641 Genomic DNA Translation: AJY57688.1
KP973642 Genomic DNA Translation: AJY57854.1
KP745681 Genomic DNA Translation: AKI15595.1
KP745691 Genomic DNA Translation: AKI17263.1
KP745697 Genomic DNA Translation: AKI18264.1
KU221090 Genomic DNA Translation: ALT14599.1
KU221091 Genomic DNA Translation: ALT14764.1
KU221092 Genomic DNA Translation: ALT14929.1
KU221093 Genomic DNA Translation: ALT15094.1
KU221094 Genomic DNA Translation: ALT15259.1
KU221095 Genomic DNA Translation: ALT15424.1
KU221096 Genomic DNA Translation: ALT15589.1
KU221097 Genomic DNA Translation: ALT15754.1
KU221098 Genomic DNA Translation: ALT15919.1
KU221099 Genomic DNA Translation: ALT16075.1
KU221100 Genomic DNA Translation: ALT16240.1
KT726946 Genomic DNA Translation: AMJ53546.1
KT726952 Genomic DNA Translation: AMJ54547.1
KY490066 Genomic DNA Translation: AQN70135.1
KY490074 Genomic DNA Translation: AQN71482.1
RefSeqiYP_081468.2, NC_006273.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi3077499
KEGGivg:3077499

Phylogenomic databases

KOiK21041

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
SUPFAMiSSF48726, SSF48726, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF5H984_HCMV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F5H984
Secondary accession number(s): A0A1D6WUX2, D2K3H8, Q6SWC2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 31, 2012
Last modified: August 12, 2020
This is version 36 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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