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UniProtKB - F5H8B0 (F5H8B0_HUMAN)
Protein
Submitted name:
Coagulation factor VII
Gene
F7
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 169 | Charge relay systemUniRule annotation | 1 | |
Active sitei | 218 | Charge relay systemUniRule annotation | 1 | |
Active sitei | 320 | Charge relay systemUniRule annotation | 1 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- serine-type endopeptidase activity Source: InterPro
GO - Biological processi
- blood coagulation Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Serine proteaseUniRule annotationARBA annotation |
Ligand | CalciumARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Coagulation factor VIIImported |
Gene namesi | Name:F7Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3544, F7 |
VEuPathDBi | HostDB:ENSG00000057593 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5003324769 | 21 – 382 | Sequence analysisAdd BLAST | 362 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 48 ↔ 57 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotation, HydroxylationARBA annotationProteomic databases
PeptideAtlasi | F5H8B0 |
PRIDEi | F5H8B0 |
ProteomicsDBi | 27733 |
Expressioni
Gene expression databases
Bgeei | ENSG00000057593, Expressed in right lobe of liver and 141 other tissues |
ExpressionAtlasi | F5H8B0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 58 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 129 – 368 | Peptidase S1InterPro annotationAdd BLAST | 240 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000154474 |
OrthoDBi | 1314811at2759 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR033190, F7 IPR012224, Pept_S1A_FX IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
PANTHERi | PTHR24278:SF26, PTHR24278:SF26, 1 hit |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001143, Factor_X, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00181, EGF, 2 hits SM00179, EGF_CA, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00022, EGF_1, 1 hit PS50026, EGF_3, 1 hit PS01187, EGF_CA, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F5H8B0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSQALRLLC LLLGLQGCLA ADGDQCASSP CQNGGSCKDQ LQSYICFCLP
60 70 80 90 100
AFEGRNCETH KDDQLICVNE NGGCEQYCSD HTGTKRSCRC HEGYSLLADG
110 120 130 140 150
VSCTPTVEYP CGKIPILEKR NASKPQGRIV GGKVCPKGEC PWQVLLLVNG
160 170 180 190 200
AQLCGGTLIN TIWVVSAAHC FDKIKNWRNL IAVLGEHDLS EHDGDEQSRR
210 220 230 240 250
VAQVIIPSTY VPGTTNHDIA LLRLHQPVVL TDHVVPLCLP ERTFSERTLA
260 270 280 290 300
FVRFSLVSGW GQLLDRGATA LELMVLNVPR LMTQDCLQQS RKVGDSPNIT
310 320 330 340 350
EYMFCAGYSD GSKDSCKGDS GGPHATHYRG TWYLTGIVSW GQGCATVGHF
360 370 380
GVYTRVSQYI EWLQKLMRSE PRPGVLLRAP FP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP08709 | FA7_HUMAN | Coagulation factor VII | F7 | 466 | Annotation score: | ||
E9PH36 | E9PH36_HUMAN | Coagulation factor VII | F7 | 74 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL137002 Genomic DNA No translation available. |
RefSeqi | NP_001254483.1, NM_001267554.1 |
Genome annotation databases
Ensembli | ENST00000541084; ENSP00000442051; ENSG00000057593 |
GeneIDi | 2155 |
UCSCi | uc010tjt.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL137002 Genomic DNA No translation available. |
RefSeqi | NP_001254483.1, NM_001267554.1 |
3D structure databases
SMRi | F5H8B0 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | F5H8B0 |
PRIDEi | F5H8B0 |
ProteomicsDBi | 27733 |
Protocols and materials databases
Antibodypediai | 11679, 661 antibodies from 37 providers |
DNASUi | 2155 |
Genome annotation databases
Ensembli | ENST00000541084; ENSP00000442051; ENSG00000057593 |
GeneIDi | 2155 |
UCSCi | uc010tjt.4, human |
Organism-specific databases
CTDi | 2155 |
HGNCi | HGNC:3544, F7 |
OpenTargetsi | ENSG00000057593 |
VEuPathDBi | HostDB:ENSG00000057593 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154474 |
OrthoDBi | 1314811at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2155, 9 hits in 1040 CRISPR screens |
GenomeRNAii | 2155 |
Gene expression databases
Bgeei | ENSG00000057593, Expressed in right lobe of liver and 141 other tissues |
ExpressionAtlasi | F5H8B0, baseline and differential |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR033190, F7 IPR012224, Pept_S1A_FX IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
PANTHERi | PTHR24278:SF26, PTHR24278:SF26, 1 hit |
Pfami | View protein in Pfam PF00008, EGF, 1 hit PF00089, Trypsin, 1 hit |
PIRSFi | PIRSF001143, Factor_X, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00181, EGF, 2 hits SM00179, EGF_CA, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS00022, EGF_1, 1 hit PS50026, EGF_3, 1 hit PS01187, EGF_CA, 1 hit PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F5H8B0_HUMAN | |
Accessioni | F5H8B0Primary (citable) accession number: F5H8B0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | October 29, 2014 | |
Last modified: | January 19, 2022 | |
This is version 76 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |