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Protein

V-type proton ATPase subunit a

Gene

ATP6V0A2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transportUniRule annotation, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit aUniRule annotation
Gene namesi
Name:ATP6V0A2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000185344.13
HGNCiHGNC:18481 ATP6V0A2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei66 – 88HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185344

PTM / Processingi

Proteomic databases

MaxQBiF5H847
PeptideAtlasiF5H847
PRIDEiF5H847

Expressioni

Gene expression databases

BgeeiENSG00000185344
ExpressionAtlasiF5H847 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5H847
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase 116 kDa subunit family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2189 Eukaryota
COG1269 LUCA
GeneTreeiENSGT00390000004941

Family and domain databases

InterProiView protein in InterPro
IPR002490 V-ATPase_116kDa_su
PANTHERiPTHR11629 PTHR11629, 1 hit
PfamiView protein in Pfam
PF01496 V_ATPase_I, 1 hit

Sequencei

Sequence statusi: Fragment.

F5H847-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACEEFNFGE ILMTQVIHSI EYCLGCISNT ASYLRLWALS LAHAQLSDVL
60 70 80 90 100
WAMLMRVGLR VDTTYGVLLL LPVIALFAVL TIFILLIMEG LSAFLHAIRL
110 120 130
HWVEFQNKFY VGAGTKFVPF SFSLLSSKFN N
Length:131
Mass (Da):14,797
Last modified:June 28, 2011 - v1
Checksum:iA7F818A21436B5BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei131Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117503 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000534943; ENSP00000443726; ENSG00000185344
UCSCiuc058uva.1 human

Similar proteinsi

Entry informationi

Entry nameiF5H847_HUMAN
AccessioniPrimary (citable) accession number: F5H847
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: July 18, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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