UniProtKB - F5H7V1 (F5H7V1_HUMAN)
Protein
Submitted name:
Nardilysin
Gene
NRDC
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- metal ion binding Source: InterPro
- metallopeptidase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, MetalloproteaseARBA annotation, Protease |
Ligand | ZincARBA annotation |
Enzyme and pathway databases
SignaLinki | F5H7V1 |
Names & Taxonomyi
Protein namesi | Submitted name: NardilysinImported |
Gene namesi | Name:NRDCImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7995, NRDC |
VEuPathDBi | HostDB:ENSG00000078618.19 |
Expressioni
Gene expression databases
Bgeei | ENSG00000078618, Expressed in quadriceps femoris and 244 other tissues |
ExpressionAtlasi | F5H7V1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 203 – 336 | Peptidase_M16InterPro annotationAdd BLAST | 134 | |
Domaini | 363 – 547 | Peptidase_M16_CInterPro annotationAdd BLAST | 185 | |
Domaini | 553 – 834 | Peptidase_M16_MInterPro annotationAdd BLAST | 282 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 53 – 108 | DisorderedSequence analysisAdd BLAST | 56 | |
Regioni | 133 – 207 | DisorderedSequence analysisAdd BLAST | 75 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 59 – 73 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 78 – 95 | PolyampholyteSequence analysisAdd BLAST | 18 | |
Compositional biasi | 140 – 196 | AcidicSequence analysisAdd BLAST | 57 |
Sequence similaritiesi
Belongs to the peptidase M16 family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00940000155026 |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR001431, Pept_M16_Zn_BS IPR007863, Peptidase_M16_C IPR032632, Peptidase_M16_M |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit PF05193, Peptidase_M16_C, 1 hit PF16187, Peptidase_M16_M, 1 hit |
SUPFAMi | SSF63411, SSF63411, 3 hits |
PROSITEi | View protein in PROSITE PS00143, INSULINASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
F5H7V1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLRRVTVAAV CATRRKLCEA GRELAALWGI ETRGRCEDSA AARPFPILAM
60 70 80 90 100
PGRNKAKSTC SCPDLQPNGQ DLGENSRVAR LGADESEEEG RRGSLSNAGD
110 120 130 140 150
PEIVKSPSDP KQYRYIKLQN GLQALLISDL SNMEGKTGNT TDDEEEEEVE
160 170 180 190 200
EEEEDDDEDS GAEIEDDDEE GFDDEDEFDD EHDDDLDTED NELEELEERA
210 220 230 240 250
EARKKTTEKQ SAAALCVGVG SFADPDDLPG LAHFLEHMVF MGSLKYPDEN
260 270 280 290 300
GFDAFLKKHG GSDNASTDCE RTVFQFDVQR KYFKEALDRW AQFFIHPLMI
310 320 330 340 350
RDAIDREVEA VDSEYQLARP SDANRKEMLF GSLARPGHPM GKFFWGNAET
360 370 380 390 400
LKHEPRKNNI DTHARLREFW MRYYSSHYMT LVVQSKETLD TLEKWVTEIF
410 420 430 440 450
SQIPNNGLPR PNFGHLTDPF DTPAFNKLYR VVPIRKIHAL TITWALPPQQ
460 470 480 490 500
QHYRVKPLHY ISWLVGHEGK GSILSFLRKK CWALALFGGN GETGFEQNST
510 520 530 540 550
YSVFSISITL TDEGYEHFYE VAYTVFQYLK MLQKLGPEKR IFEEIRKIED
560 570 580 590 600
NEFHYQEQTD PVEYVENMCE NMQLYPLQDI LTGDQLLFEY KPEVIGEALN
610 620 630 640 650
QLVPQKANLV LLSGANEGKC DLKEKWFGTQ YSIEDIENSW AELWNSNFEL
660 670 680 690 700
NPDLHLPAEN KYIATDFTLK AFDCPETEYP VKIVNTPQGC LWYKKDNKFK
710 720 730 740 750
IPKAYIRFHL ISPLIQKSAA NVVLFDIFVN ILTHNLAEPA YEADVAQLEY
760 770 780 790 800
KLVAGEHGLI IRVKGFNHKL PLLFQLIIDY LAEFNSTPAV FTMITEQLKK
810 820 830 840 850
TYFNILIKPE TLAKDVRLLI LEYARWSMID KYQALMDGLS LESLLSFVKE
860 870 880 890 900
FKSQLFVEGL VQGNVTSTES MDFLKYVVDK LNFKPLEQEM PVQFQVVELP
910 920 930 940
SGHHLCKVKA LNKGDANSEV TVYYQVRYQE SKRIYAYGAA CDAHGRTLF
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO43847 | NRDC_HUMAN | Nardilysin | NRDC NRD1 | 1,151 | Annotation score: | ||
G3V1R5 | G3V1R5_HUMAN | Nardilysin | NRDC NRD1, hCG_40292 | 1,087 | Annotation score: | ||
H0Y5G9 | H0Y5G9_HUMAN | Nardilysin | NRDC | 538 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL050343 Genomic DNA No translation available. AL589663 Genomic DNA No translation available. KF495940 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000544028; ENSP00000442262; ENSG00000078618 |
UCSCi | uc057gmm.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL050343 Genomic DNA No translation available. AL589663 Genomic DNA No translation available. KF495940 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | F5H7V1 |
PRIDEi | F5H7V1 |
ProteomicsDBi | 27600 |
Protocols and materials databases
Antibodypediai | 19043, 140 antibodies |
Genome annotation databases
Ensembli | ENST00000544028; ENSP00000442262; ENSG00000078618 |
UCSCi | uc057gmm.1, human |
Organism-specific databases
HGNCi | HGNC:7995, NRDC |
OpenTargetsi | ENSG00000078618 |
VEuPathDBi | HostDB:ENSG00000078618.19 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155026 |
Enzyme and pathway databases
SignaLinki | F5H7V1 |
Miscellaneous databases
ChiTaRSi | NRDC, human |
Gene expression databases
Bgeei | ENSG00000078618, Expressed in quadriceps femoris and 244 other tissues |
ExpressionAtlasi | F5H7V1, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR001431, Pept_M16_Zn_BS IPR007863, Peptidase_M16_C IPR032632, Peptidase_M16_M |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit PF05193, Peptidase_M16_C, 1 hit PF16187, Peptidase_M16_M, 1 hit |
SUPFAMi | SSF63411, SSF63411, 3 hits |
PROSITEi | View protein in PROSITE PS00143, INSULINASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F5H7V1_HUMAN | |
Accessioni | F5H7V1Primary (citable) accession number: F5H7V1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | October 29, 2014 | |
Last modified: | February 10, 2021 | |
This is version 75 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |