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Protein
Submitted name:

Ras GTPase-activating-like protein IQGAP2

Gene

IQGAP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Ras GTPase-activating-like protein IQGAP2Imported
Gene namesi
Name:IQGAP2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145703.15
HGNCiHGNC:6111 IQGAP2

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000145703

PTM / Processingi

Proteomic databases

EPDiF5H7S7
PeptideAtlasiF5H7S7
PRIDEiF5H7S7

Expressioni

Gene expression databases

BgeeiENSG00000145703
ExpressionAtlasiF5H7S7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5H7S7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 106Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini544 – 577WWInterPro annotationAdd BLAST34
Domaini867 – 1100Ras-GAPInterPro annotationAdd BLAST234

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili115 – 142Sequence analysisAdd BLAST28
Coiled coili212 – 232Sequence analysisAdd BLAST21
Coiled coili754 – 774Sequence analysisAdd BLAST21
Coiled coili1361 – 1388Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG2128 Eukaryota
COG5261 LUCA
GeneTreeiENSGT00600000084379

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR000048 IQ_motif_EF-hand-BS
IPR000593 RasGAP_C
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001202 WW_dom
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF00612 IQ, 2 hits
PF00616 RasGAP, 1 hit
PF03836 RasGAP_C, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00015 IQ, 3 hits
SM00323 RasGAP, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48350 SSF48350, 2 hits
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS50096 IQ, 3 hits
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

F5H7S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVCLVEELP PTTELEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY
60 70 80 90 100
KKSGLHFRHT DNTVQWLRAM ESIGLPKIFY PETTDVYDRK NIPRMIYCIH
110 120 130 140 150
ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS NMRKELEKYG IQMPSFSKIG
160 170 180 190 200
GILANELSVD EAALHAAVIA INEAVEKGIA EQTVVTLRNP NAVLTLVDDN
210 220 230 240 250
LAPEYQKELW DAKKKKEENA RLKNSCISEE ERDAYEELLT QAEIQGNINK
260 270 280 290 300
VNRQAAVDHI NAVIPEGDPE NTLLALKKPE AQLPAVYPFA AAMYQNELFN
310 320 330 340 350
LQKQNTMNYL AHEELLIAVE MLSAVALLNQ ALESNDLVSV QNQLRSPAIG
360 370 380 390 400
LNNLDKAYVE RYANTLLSVK LEVLSQGQDN LSWNEIQNCI DMVNAQIQEE
410 420 430 440 450
NDRVVAVGYI NEAIDEGNPL RTLETLLLPT ANISDVDPAH AQHYQDVLYH
460 470 480 490 500
AKSQKLGDSE SVSKVLWLDE IQQAVDDANV DKDRAKQWVT LVVDVNQCLE
510 520 530 540 550
GKKSSDILSV LKSSTSNAND IIPECADKYY DALVKAKELK SERVSSDGSW
560 570 580 590 600
LKLNLHKKYD YYYNTDSKES SWVTPESCLY KESWLTGKEI EDIIEEVTVG
610 620 630 640 650
YIRENIWSAS EELLLRFQAT SSGPILREEF EARKSFLHEQ EENVVKIQAF
660 670 680 690 700
WKGYKQRKEY MHRRQTFIDN TDSIVKIQSW FRMATARKSY LSRLQYFRDH
710 720 730 740 750
NNEIVKIQSL LRANKARDDY KTLVGSENPP LTVIRKFVYL LDQSDLDFQE
760 770 780 790 800
ELEVARLREE VVTKIRANQQ LEKDLNLMDI KIGLLVKNRI TLEDVISHSK
810 820 830 840 850
KLNKKKGGEM EILNNTDNQG IKSLSKERRK TLETYQQLFY LLQTNPLYLA
860 870 880 890 900
KLIFQMPQNK STKFMDTVIF TLYNYASNQR EEYLLLKLFK TALEEEIKSK
910 920 930 940 950
VDQVQDIVTG NPTVIKMVVS FNRGARGQNT LRQLLAPVVK EIIDDKSLII
960 970 980 990 1000
NTNPVEVYKA WVNQLETQTG EASKLPYDVT TEQALTYPEV KNKLEASIEN
1010 1020 1030 1040 1050
LRRVTDKVLN SIISSLDLLP YGLRYIAKVL KNSIHEKFPD ATEDELLKIV
1060 1070 1080 1090 1100
GNLLYYRYMN PAIVAPDGFD IIDMTAGGQI NSDQRRNLGS VAKVLQHAAS
1110 1120 1130 1140 1150
NKLFEGENEH LSSMNNYLSE TYQEFRKYFK EACNVPEPEE KFNMDKYTDL
1160 1170 1180 1190 1200
VTVSKPVIYI SIEEIISTHS LLLEHQDAIA PEKNDLLSEL LGSLGEVPTV
1210 1220 1230 1240 1250
ESFLGEGAVD PNDPNKANTL SQLSKTEISL VLTSKYDIED GEAIDSRSLM
1260 1270 1280 1290 1300
IKTKKLIIDV IRNQPGNTLT EILETPATAQ QEVDHATDMV SRAMIDSRTP
1310 1320 1330 1340 1350
EEMKHSQSMI EDAQLPLEQK KRKIQRNLRT LEQTGHVSSE NKYQDILNEI
1360 1370 1380 1390 1400
AKDIRNQRIY RKLRKAELAK LQQTLNALNK KAAFYEEQIN YYDTYIKTCL
1410 1420 1430 1440 1450
DNLKRKNTRR SIKLDGKGEP KGAKRAKPVK YTAAKLHEKG VLLDIDDLQT
1460 1470 1480 1490 1500
NQFKNVTFDI IATEDVGIFD VRSKFLGVEM EKVQLNIQDL LQMQYEGVAV
1510 1520
MKMFDKVKVN VNLLIYLLNK KFYGK
Length:1,525
Mass (Da):174,449
Last modified:October 29, 2014 - v2
Checksum:iE6BE25FC4666E642
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025188 Genomic DNA No translation available.
AC026706 Genomic DNA No translation available.
AC026725 Genomic DNA No translation available.
AC093251 Genomic DNA No translation available.
AC112173 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000379730; ENSP00000442313; ENSG00000145703
UCSCiuc032uza.2 human

Similar proteinsi

Entry informationi

Entry nameiF5H7S7_HUMAN
AccessioniPrimary (citable) accession number: F5H7S7
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 29, 2014
Last modified: June 20, 2018
This is version 63 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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