UniProtKB - F5H7C6 (F5H7C6_HUMAN)

BLAST

>tr|F5H7C6|F5H7C6_HUMAN COP9 signalosome complex subunit 7a (Fragment) OS=Homo sapiens OX=9606 GN=COPS7A PE=1 SV=1
MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDF
ASTFRLLTVFAYGTYADYLAEARNLPPLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEAL
ALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQDLSAIARTLQEWCVG
CEVVLSGIEEQV

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History
Entry version 48 (12 Sep 2018)
Sequence version 1 (28 Jun 2011)
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Protein

Submitted name:

COP9 signalosome complex subunit 7a

Gene

COPS7A

Organism

Homo sapiens (Human)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: COP9 signalosome complex subunit 7aImported
Gene namesⁱ	Name:COPS7AImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000111652.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16758 COPS7A

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000111652

OpenTargetsⁱ

ENSG00000111652

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	F5H7C6
PeptideAtlas More...PeptideAtlasⁱ	F5H7C6
PRIDEⁱ	F5H7C6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000111652 Expressed in 232 organ(s), highest expression level in anterior cingulate cortex
ExpressionAtlasⁱ	F5H7C6 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	F5H7C6
SMRⁱ	F5H7C6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1 – 159	PCIInterPro annotationAdd BLAST		159

Phylogenomic databases

eggNOGⁱ	KOG3250 Eukaryota ENOG410XP7W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013069

Family and domain databases

InterProⁱ	View protein in InterPro IPR037757 COPS7A IPR000717 PCI_dom
PANTHERⁱ	PTHR15350:SF7 PTHR15350:SF7, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01399 PCI, 1 hit
SMARTⁱ	View protein in SMART SM00088 PINT, 1 hit
PROSITEⁱ	View protein in PROSITE PS50250 PCI, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Fragment.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show all Align All

F5H7C6-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MSAEVKVTGQ NQEQFLLLAK SAKGAALATL IHQVLEAPGV YVFGELLDMP 
        60         70         80         90        100
NVRELAESDF ASTFRLLTVF AYGTYADYLA EARNLPPLTE AQKNKLRHLS 
       110        120        130        140        150
VVTLAAKVKC IPYAVLLEAL ALRNVRQLED LVIEAVYADV LRGSLDQRNQ 
       160        170        180        190 
RLEVDYSIGR DIQRQDLSAI ARTLQEWCVG CEVVLSGIEE QV

Length:192

Mass (Da):21,307

Last modified:June 28, 2011 - v1

Checksum:ⁱF7C4817B819EB5A2

Computationally mapped potential isoform sequencesⁱ

There are 8 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q9UBW8	CSN7A_HUMAN	COP9 signalosome complex subunit 7a COP9 signalosome complex subunit 7a, SGN7a, Signalosome subunit 7a (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a)	COPS7A CSN7A, DERP10	275	Annotation score:
F5H248	F5H248_HUMAN	COP9 signalosome complex subunit 7a COP9 signalosome complex subunit 7a	COPS7A	262	Annotation score:
F5GYF7	F5GYF7_HUMAN	COP9 signalosome complex subunit 7a COP9 signalosome complex subunit 7a	COPS7A	212	Annotation score:
F5H4U8	F5H4U8_HUMAN	COP9 signalosome complex subunit 7a COP9 signalosome complex subunit 7a	COPS7A	125	Annotation score:
F5H3M6	F5H3M6_HUMAN	COP9 signalosome complex subunit 7a COP9 signalosome complex subunit 7a	COPS7A	60	Annotation score:
F5H4Z0	F5H4Z0_HUMAN	COP9 signalosome complex subunit 7a COP9 signalosome complex subunit 7a	COPS7A	56	Annotation score:
F5GXT7	F5GXT7_HUMAN	COP9 signalosome complex subunit 7a COP9 signalosome complex subunit 7a	COPS7A	71	Annotation score:
G3XAP1	G3XAP1_HUMAN	COP9 constitutive photomorphogenic ... COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis), isoform CRA_b (COP9 signalosome complex subunit 7a)	COPS7A hCG_25925	62	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	192	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC125494 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC125494 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000541866; ENSP00000442613; ENSG00000111652
UCSC genome browser More...UCSCⁱ	uc058kjz.1 human

Protein	Similar proteins		Species	Score	Length	Source
F5H7C6	COP9 signalosome complex subunit 7a		MYOBR		275	UniRef100_S7PNF1
COP9 signalosome complex subunit 7a (Fragment)		HUMAN		212
COPS7A isoform 20 (Fragment)		PONAB		213
COP9 signalosome complex subunit 7a		MYODS		275
Uncharacterized protein		MYOLU		275
+4

Protein	Similar proteins		Species	Score	Length	Source
F5H7C6	COP9 signalosome complex subunit 7a	)	HUMAN		275	UniRef90_Q9UBW8
COP9 signalosome complex subunit 7a		PONAB		275
COP9 signalosome complex subunit 7a		MOUSE		275
COP9 signalosome complex subunit 7a		CALJA		275
COP9 constitutive photomorphogenic homolog subunit 7A		PANTR		275
+83

Protein	Similar proteins		Species	Score	Length	Source
F5H7C6	COP9 signalosome complex subunit 7a	)	HUMAN		275	UniRef50_Q9UBW8
COP9 signalosome complex subunit 7a		PONAB		275
COP9 signalosome complex subunit 7a		MOUSE		275
COP9 signalosome complex subunit 7b		BOVIN		264
COP9 signalosome complex subunit 7a		CALJA		275
+264

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC125494 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AC125494 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	F5H7C6
SMRⁱ	F5H7C6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQBⁱ	F5H7C6
PeptideAtlasⁱ	F5H7C6
PRIDEⁱ	F5H7C6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000541866; ENSP00000442613; ENSG00000111652
UCSCⁱ	uc058kjz.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000111652.9
HGNCⁱ	HGNC:16758 COPS7A
OpenTargetsⁱ	ENSG00000111652
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3250 Eukaryota ENOG410XP7W LUCA
GeneTreeⁱ	ENSGT00390000013069

Miscellaneous databases

ChiTaRSⁱ	COPS7A human

ChiTaRSⁱ

COPS7A human

Gene expression databases

Bgeeⁱ	ENSG00000111652 Expressed in 232 organ(s), highest expression level in anterior cingulate cortex
ExpressionAtlasⁱ	F5H7C6 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR037757 COPS7A IPR000717 PCI_dom
PANTHERⁱ	PTHR15350:SF7 PTHR15350:SF7, 1 hit
Pfamⁱ	View protein in Pfam PF01399 PCI, 1 hit
SMARTⁱ	View protein in SMART SM00088 PINT, 1 hit
PROSITEⁱ	View protein in PROSITE PS50250 PCI, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F5H7C6_HUMAN
Accessionⁱ	F5H7C6Primary (citable) accession number: F5H7C6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 28, 2011
	Last sequence update:	June 28, 2011
	Last modified:	September 12, 2018
	This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - F5H7C6 (F5H7C6_HUMAN)

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COP9 signalosome complex subunit 7a

COPS7A

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ