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Protein
Submitted name:

Tumor necrosis factor receptor superfamily member 1A

Gene

TNFRSF1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor necrosis factor receptor superfamily member 1AImported
Gene namesi
Name:TNFRSF1AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000067182.7
HGNCiHGNC:11916 TNFRSF1A

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei12 – 31HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000067182

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi75 ↔ 90PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

MaxQBiF5H6Z2
PeptideAtlasiF5H6Z2
PRIDEiF5H6Z2

Expressioni

Gene expression databases

BgeeiENSG00000067182 Expressed in 226 organ(s), highest expression level in tendon of biceps brachii
ExpressionAtlasiF5H6Z2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5H6Z2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 116TNFR-CysInterPro annotationAdd BLAST43
Repeati74 – 116TNFR-CysPROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00530000064001

Family and domain databases

InterProiView protein in InterPro
IPR001368 TNFR/NGFR_Cys_rich_reg
PfamiView protein in Pfam
PF00020 TNFR_c6, 1 hit
SMARTiView protein in SMART
SM00208 TNFR, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.iShow all

F5H6Z2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLSTVPDLL LPLVLLELLV GIYPSGVIGL VPHLGDREKR DSVCPQGKYI
60 70 80 90 100
HPQNNSICCT KCHKGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM
110
GQVEISSCTV DRDTVCGC
Length:118
Mass (Da):12,820
Last modified:June 28, 2011 - v1
Checksum:i144161C6D28BB140
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P19438TNR1A_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF1A TNFAR, TNFR1
455Annotation score:
F5H8A6F5H8A6_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF1A
298Annotation score:
F5H6V7F5H6V7_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF1A
254Annotation score:
F5H061F5H061_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF1A
412Annotation score:
F5H7N1F5H7N1_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF1A
72Annotation score:
F5H4T5F5H4T5_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF1A
71Annotation score:
F5GWJ4F5GWJ4_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF1A
122Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei118Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006057 Genomic DNA No translation available.
KF455591 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000536194; ENSP00000442919; ENSG00000067182
UCSCiuc058kde.1 human

Similar proteinsi

Entry informationi

Entry nameiF5H6Z2_HUMAN
AccessioniPrimary (citable) accession number: F5H6Z2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 12, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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