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Protein

Integrin beta

Gene

ITGB7

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotation
Biological processCell adhesionUniRule annotation

Enzyme and pathway databases

SignaLinkiF5H6T4

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin betaUniRule annotation
Gene namesi
Name:ITGB7Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139626.15
HGNCiHGNC:6162 ITGB7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139626

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500332727720 – 471Integrin betaSequence analysisAdd BLAST452

Proteomic databases

MaxQBiF5H6T4
PeptideAtlasiF5H6T4
PRIDEiF5H6T4

Expressioni

Gene expression databases

BgeeiENSG00000139626 Expressed in 182 organ(s), highest expression level in material anatomical entity
ExpressionAtlasiF5H6T4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5H6T4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 92PSIInterPro annotationAdd BLAST49
Domaini50 – 462INBInterPro annotationAdd BLAST413

Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

SignalSequence analysis, TransmembraneUniRule annotation

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
GeneTreeiENSGT00760000119064

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015437 Integrin_bsu-7
IPR002369 Integrin_bsu_VWA
IPR016201 PSI
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF36 PTHR10082:SF36, 1 hit
PfamiView protein in Pfam
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM00423 PSI, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.iShow all

F5H6T4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVALPMVLVL LLVLSRGESE LDAKIPSTGD ATEWRNPHLS MLGSCQPAPS
60 70 80 90 100
CQKCILSHPS CAWCKQLNFT ASGEAEARRC ARREELLARG CPLEELEEPR
110 120 130 140 150
GQQEVLQDQP LSQGARGEGA TQLAPQRVRV TLRPGEPQQL QVRFLRAEGY
160 170 180 190 200
PVDLYYLMDL SYSMKDDLER VRQLGHALLV RLQEVTHSVR IGFGSFVDKT
210 220 230 240 250
VLPFVSTVPS KLRHPCPTRL ERCQSPFSFH HVLSLTGDAQ AFEREVGRQS
260 270 280 290 300
VSGNLDSPEG GFDAILQAAL CQEQIGWRNV SRLLVFTSDD TFHTAGDGKL
310 320 330 340 350
GGIFMPSDGH CHLDSNGLYS RSTEFDYPSV GQVAQALSAA NIQPIFAVTS
360 370 380 390 400
AALPVYQELS KLIPKSAVGE LSEDSSNVVQ LIMDAYNSLS STVTLEHSSL
410 420 430 440 450
PPGVHISYES QCEGPEKREG KAEDRGQCNH VRINQTGLCR VWGLQDWPTG
460 470
HQLQYSLCPY QCDPGLGPYL G
Length:471
Mass (Da):51,799
Last modified:June 28, 2011 - v1
Checksum:i43605D33985A5454
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P26010ITB7_HUMAN
Integrin beta-7
ITGB7
798Annotation score:
F8VNX4F8VNX4_HUMAN
Integrin beta-7
ITGB7
158Annotation score:
H3BRM2H3BRM2_HUMAN
Integrin beta-7
ITGB7
93Annotation score:
F8W186F8W186_HUMAN
Integrin beta-7
ITGB7
88Annotation score:
H3BRX4H3BRX4_HUMAN
Integrin beta-7
ITGB7
117Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073573 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000542497; ENSP00000437375; ENSG00000139626
UCSCiuc058omk.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC073573 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliF5H6T4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiF5H6T4
PeptideAtlasiF5H6T4
PRIDEiF5H6T4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000542497; ENSP00000437375; ENSG00000139626
UCSCiuc058omk.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000139626.15
HGNCiHGNC:6162 ITGB7
OpenTargetsiENSG00000139626
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1226 Eukaryota
ENOG410XP60 LUCA
GeneTreeiENSGT00760000119064

Enzyme and pathway databases

SignaLinkiF5H6T4

Miscellaneous databases

ChiTaRSiITGB7 human

Gene expression databases

BgeeiENSG00000139626 Expressed in 182 organ(s), highest expression level in material anatomical entity
ExpressionAtlasiF5H6T4 baseline and differential

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR015437 Integrin_bsu-7
IPR002369 Integrin_bsu_VWA
IPR016201 PSI
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 1 hit
PTHR10082:SF36 PTHR10082:SF36, 1 hit
PfamiView protein in Pfam
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00187 INB, 1 hit
SM00423 PSI, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF5H6T4_HUMAN
AccessioniPrimary (citable) accession number: F5H6T4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 12, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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