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Protein
Submitted name:

Pyrin

Gene

MEFV

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
PyrinImported
Gene namesi
Name:MEFVImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000103313.11
HGNCiHGNC:6998 MEFV

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000103313

PTM / Processingi

Proteomic databases

PeptideAtlasiF5H6N9
PRIDEiF5H6N9

Expressioni

Gene expression databases

BgeeiENSG00000103313 Expressed in 81 organ(s), highest expression level in blood
ExpressionAtlasiF5H6N9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5H6N9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 92PyrinInterPro annotationAdd BLAST92
Domaini370 – 412B box-typeInterPro annotationAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili420 – 440Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118838

Family and domain databases

CDDicd00021 BBOX, 1 hit
InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR028841 Pyrin
IPR000315 Znf_B-box
PANTHERiPTHR45323 PTHR45323, 2 hits
PfamiView protein in Pfam
PF02758 PYRIN, 1 hit
PF00643 zf-B_box, 1 hit
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS50119 ZF_BBOX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

F5H6N9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKTPSDHLL STLEELVPYD FEKFKFKLQN TSVQKEHSRI PRSQIQRARP
60 70 80 90 100
VKMATLLVTY YGEEYAVQLT LQVLRAINQR LLAEELHRAA IQEYSTQENG
110 120 130 140 150
TDDSAASSSL GENKPRSLKT PDHPEGNEGN GPRPYGGGAA SLRCSQPEAG
160 170 180 190 200
RGLSRKPLSK RREKASEGLD AQGKPRTRSP ALPGGRSPGP CRALEGGQAE
210 220 230 240 250
VRLRRNASSA GRLQGLAGGA PGQKECRPFE VYLPSGKMRP RSLEVTISTG
260 270 280 290 300
EKAPANPEIL LTLEEKTAAN LDSATEPRAR PTPDGGASAD LKEGPGNPEH
310 320 330 340 350
SVTGRPPDTA ASPRCHAQEG DPVDGTCVRD SCSFPEAVSG HPQASGSRSP
360 370 380 390 400
GCPRCQDSHE RKSPGSLSPQ PLPQCKRHLK QVQLLFCEDH DEPICLICSL
410 420 430 440 450
SQEHQGHRVR PIEEVALEHK KKIQKQLEHL KKLRKSGEEQ RSYGEEKAVS
460 470 480 490
FLVVVQWCDL GSLQPLPPGF KRFSCLSLLS SWDYRNKLKR
Length:490
Mass (Da):53,684
Last modified:June 28, 2011 - v1
Checksum:i4D272D3014F33D84
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O15553MEFV_HUMAN
Pyrin
MEFV MEF, TRIM20
781Annotation score:
F8W6Z2F8W6Z2_HUMAN
Pyrin
MEFV
601Annotation score:
F5GZV9F5GZV9_HUMAN
Pyrin
MEFV
402Annotation score:
F5H2E5F5H2E5_HUMAN
Pyrin
MEFV
613Annotation score:
F5H595F5H595_HUMAN
Pyrin
MEFV
644Annotation score:
D2DTW1D2DTW1_HUMAN
Pyrin/marenostrin variant del234
MEFV
95Annotation score:
E3P8H6E3P8H6_HUMAN
Pyrin/marenostrin variant del2345
MEFV
101Annotation score:
I3L0S7I3L0S7_HUMAN
Pyrin
MEFV
306Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003147 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000538326; ENSP00000437486; ENSG00000103313
UCSCiuc059pwp.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ003147 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliF5H6N9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiF5H6N9
PRIDEiF5H6N9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000538326; ENSP00000437486; ENSG00000103313
UCSCiuc059pwp.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000103313.11
HGNCiHGNC:6998 MEFV
OpenTargetsiENSG00000103313
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177 Eukaryota
ENOG4111G04 LUCA
GeneTreeiENSGT00760000118838

Gene expression databases

BgeeiENSG00000103313 Expressed in 81 organ(s), highest expression level in blood
ExpressionAtlasiF5H6N9 baseline and differential

Family and domain databases

CDDicd00021 BBOX, 1 hit
InterProiView protein in InterPro
IPR004020 DAPIN
IPR011029 DEATH-like_dom_sf
IPR028841 Pyrin
IPR000315 Znf_B-box
PANTHERiPTHR45323 PTHR45323, 2 hits
PfamiView protein in Pfam
PF02758 PYRIN, 1 hit
PF00643 zf-B_box, 1 hit
SMARTiView protein in SMART
SM00336 BBOX, 1 hit
SM01289 PYRIN, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50824 DAPIN, 1 hit
PS50119 ZF_BBOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF5H6N9_HUMAN
AccessioniPrimary (citable) accession number: F5H6N9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: September 12, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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