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Protein

Beta-2-microglobulin

Gene

B2M

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.SAAS annotation

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-2-microglobulinSAAS annotation
Gene namesi
Name:B2MImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000166710.17
HGNCiHGNC:914 B2M

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MHC ISAAS annotation, SecretedSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166710

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501408979021 – 101Beta-2-microglobulinSequence analysisAdd BLAST81

Proteomic databases

PeptideAtlasiF5H6I0
PRIDEiF5H6I0

Expressioni

Gene expression databases

BgeeiENSG00000166710
ExpressionAtlasiF5H6I0 baseline and differential

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules.SAAS annotation

Structurei

3D structure databases

SMRiF5H6I0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 92IGc1InterPro annotationAdd BLAST60

Sequence similaritiesi

Belongs to the beta-2-microglobulin family.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00690000102227

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015707 B2Microglobulin
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PANTHERiPTHR19944:SF62 PTHR19944:SF62, 2 hits
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

F5H6I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSVALAVL ALLSLSGLEA IQRTPKIQVY SRHPADIEVD LLKNGERIEK
60 70 80 90 100
VEHSDLSFSK DWSFYLLYYT EFTPTEKDEY ACRVNHVTLS QPKIVKWDRD

M
Length:101
Mass (Da):11,732
Last modified:October 29, 2014 - v2
Checksum:i618597495A616CEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018901 Genomic DNA No translation available.
AC025270 Genomic DNA No translation available.
AC122108 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000544417; ENSP00000437604; ENSG00000166710
ENST00000619603; ENSP00000483449; ENSG00000273686
UCSCiuc059iqm.1 human

Similar proteinsi

Entry informationi

Entry nameiF5H6I0_HUMAN
AccessioniPrimary (citable) accession number: F5H6I0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 29, 2014
Last modified: May 23, 2018
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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