UniProtKB - F5H6G4 (F5H6G4_HUMAN)
Protein
RING-type E3 ubiquitin transferase
Gene
RMND5B
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.27
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 325 – 366 | RING-Gid-typePROSITE-ProRule annotationAdd BLAST | 42 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- ubiquitin protein ligase activity Source: InterPro
Keywordsi
Molecular function | TransferaseARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:RMND5BImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26181, RMND5B |
VEuPathDBi | HostDB:ENSG00000145916.18 |
Subcellular locationi
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
CytoplasmARBA annotationPTM / Processingi
Proteomic databases
MaxQBi | F5H6G4 |
PeptideAtlasi | F5H6G4 |
PRIDEi | F5H6G4 |
ProteomicsDBi | 27183 |
Expressioni
Gene expression databases
Bgeei | ENSG00000145916, Expressed in testis and 231 other tissues |
ExpressionAtlasi | F5H6G4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 103 – 135 | LisHInterPro annotationAdd BLAST | 33 | |
Domaini | 142 – 199 | CTLHInterPro annotationAdd BLAST | 58 | |
Domaini | 325 – 366 | RING-Gid-typeInterPro annotationAdd BLAST | 42 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 325 – 366 | RING-Gid-typePROSITE-ProRule annotationAdd BLAST | 42 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000153203 |
OrthoDBi | 987270at2759 |
Family and domain databases
CDDi | cd16795, dRING_RMD5B, 1 hit |
InterProi | View protein in InterPro IPR013144, CRA_dom IPR024964, CTLH/CRA IPR006595, CTLH_C IPR006594, LisH IPR037681, RMD5B_dRING IPR044063, ZF_RING_GID |
Pfami | View protein in Pfam PF10607, CLTH, 1 hit |
SMARTi | View protein in SMART SM00757, CRA, 1 hit SM00668, CTLH, 1 hit SM00667, LisH, 1 hit |
PROSITEi | View protein in PROSITE PS50897, CTLH, 1 hit PS50896, LISH, 1 hit PS51867, ZF_RING_GID, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
F5H6G4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADCSLDLPG SSSPPSHLSL LRSWDHRRVP PCPALQGTPL SATLSLVMSQ
60 70 80 90 100
CCRKIKDTVQ KLASDHKDIH SSVSRVGKAI DRNFDSEICG VVSDAVWDAR
110 120 130 140 150
EQQQQILQMA IVEHLYQQGM LSVAEELCQE STLNVDLDFK QPFLELNRIL
160 170 180 190 200
EALHEQDLGP ALEWAVSHRQ RLLELNSSLE FKLHRLHFIR LLAGGPAKQL
210 220 230 240 250
EALSYARHFQ PFARLHQREI QVMMGSLVYL RLGLEKSPYC HLLDSSHWAE
260 270 280 290 300
ICETFTRDAC SLLGLSVESP LSVSFASGCV ALPVLMNIKA VIEQRQCTGV
310 320 330 340 350
WNHKDELPIE IELGMKCWYH SVFACPILRQ QTSDSNPPIK LICGHVISRD
360 370 380
ALNKLINGGK LKCPYCPMEQ NPADGKRIIF
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ96G75 | RMD5B_HUMAN | E3 ubiquitin-protein transferase RM... | RMND5B UNQ2508/PRO5996 | 393 | Annotation score: | ||
D6RFE6 | D6RFE6_HUMAN | E3 ubiquitin-protein transferase RM... | RMND5B | 77 | Annotation score: | ||
D6RIF9 | D6RIF9_HUMAN | E3 ubiquitin-protein transferase RM... | RMND5B | 148 | Annotation score: | ||
D6RER3 | D6RER3_HUMAN | E3 ubiquitin-protein transferase RM... | RMND5B | 114 | Annotation score: | ||
D6R9A2 | D6R9A2_HUMAN | E3 ubiquitin-protein transferase RM... | RMND5B | 62 | Annotation score: | ||
D6RFK1 | D6RFK1_HUMAN | E3 ubiquitin-protein transferase RM... | RMND5B | 56 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC136632 Genomic DNA No translation available. |
RefSeqi | NP_001275724.1, NM_001288795.1 |
Genome annotation databases
Ensembli | ENST00000542098; ENSP00000437630; ENSG00000145916 |
GeneIDi | 64777 |
UCSCi | uc063kjk.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC136632 Genomic DNA No translation available. |
RefSeqi | NP_001275724.1, NM_001288795.1 |
3D structure databases
SMRi | F5H6G4 |
ModBasei | Search... |
Proteomic databases
MaxQBi | F5H6G4 |
PeptideAtlasi | F5H6G4 |
PRIDEi | F5H6G4 |
ProteomicsDBi | 27183 |
Protocols and materials databases
Antibodypediai | 46079, 95 antibodies |
DNASUi | 64777 |
Genome annotation databases
Ensembli | ENST00000542098; ENSP00000437630; ENSG00000145916 |
GeneIDi | 64777 |
UCSCi | uc063kjk.1, human |
Organism-specific databases
CTDi | 64777 |
HGNCi | HGNC:26181, RMND5B |
OpenTargetsi | ENSG00000145916 |
VEuPathDBi | HostDB:ENSG00000145916.18 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000153203 |
OrthoDBi | 987270at2759 |
Miscellaneous databases
BioGRID-ORCSi | 64777, 7 hits in 991 CRISPR screens |
ChiTaRSi | RMND5B, human |
GenomeRNAii | 64777 |
Gene expression databases
Bgeei | ENSG00000145916, Expressed in testis and 231 other tissues |
ExpressionAtlasi | F5H6G4, baseline and differential |
Family and domain databases
CDDi | cd16795, dRING_RMD5B, 1 hit |
InterProi | View protein in InterPro IPR013144, CRA_dom IPR024964, CTLH/CRA IPR006595, CTLH_C IPR006594, LisH IPR037681, RMD5B_dRING IPR044063, ZF_RING_GID |
Pfami | View protein in Pfam PF10607, CLTH, 1 hit |
SMARTi | View protein in SMART SM00757, CRA, 1 hit SM00668, CTLH, 1 hit SM00667, LisH, 1 hit |
PROSITEi | View protein in PROSITE PS50897, CTLH, 1 hit PS50896, LISH, 1 hit PS51867, ZF_RING_GID, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F5H6G4_HUMAN | |
Accessioni | F5H6G4Primary (citable) accession number: F5H6G4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | April 7, 2021 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |