UniProtKB - F5H658 (F5H658_HUMAN)
Protein
RNA helicase
Gene
DHX8
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.6.4.13ARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- nucleic acid binding Source: InterPro
- RNA helicase activity Source: UniProtKB-EC
GO - Biological processi
- mRNA processing Source: UniProtKB-KW
- RNA splicing Source: UniProtKB-KW
Keywordsi
Molecular function | HelicaseARBA annotation, Hydrolase |
Biological process | mRNA processing, mRNA splicingARBA annotation |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:DHX8Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000067596.10 |
HGNCi | HGNC:2749, DHX8 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusARBA annotationPTM / Processingi
Proteomic databases
MaxQBi | F5H658 |
PeptideAtlasi | F5H658 |
PRIDEi | F5H658 |
ProteomicsDBi | 27088 |
Expressioni
Gene expression databases
Bgeei | ENSG00000067596, Expressed in leukocyte and 200 other tissues |
ExpressionAtlasi | F5H658, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 265 – 336 | S1 motifInterPro annotationAdd BLAST | 72 | |
Domaini | 575 – 738 | Helicase ATP-bindingInterPro annotationAdd BLAST | 164 | |
Domaini | 756 – 936 | Helicase C-terminalInterPro annotationAdd BLAST | 181 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 153 – 266 | DisorderedSequence analysisAdd BLAST | 114 | |
Regioni | 337 – 372 | DisorderedSequence analysisAdd BLAST | 36 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 475 – 495 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 195 – 226 | BasicSequence analysisAdd BLAST | 32 | |
Compositional biasi | 227 – 260 | PolyampholyteSequence analysisAdd BLAST | 34 | |
Compositional biasi | 337 – 367 | PolyampholyteSequence analysisAdd BLAST | 31 |
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155510 |
Family and domain databases
InterProi | View protein in InterPro IPR002464, DNA/RNA_helicase_DEAH_CS IPR011709, DUF1605 IPR007502, Helicase-assoc_dom IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR012340, NA-bd_OB-fold IPR027417, P-loop_NTPase IPR022967, S1_dom IPR003029, S1_domain |
Pfami | View protein in Pfam PF04408, HA2, 1 hit PF00271, Helicase_C, 1 hit PF07717, OB_NTP_bind, 1 hit PF00575, S1, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00847, HA2, 1 hit SM00490, HELICc, 1 hit SM00316, S1, 1 hit |
SUPFAMi | SSF50249, SSF50249, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00690, DEAH_ATP_HELICASE, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS50126, S1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
F5H658-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVAVAMAGA LIGSEPGPAE ELAKLEYLSL VSKVCTELDN HLGINDKDLA
60 70 80 90 100
EFVISLAEKN TTFDTFKASL VKNGAEFTDS LISNLLRLIQ TMRPPAKPST
110 120 130 140 150
SKDPVVKPKT EKEKLKELFP VLCQPDNPSV RTMLDEDDVK VAVDVLKELE
160 170 180 190 200
ALMPSAAGQE KQRDAEHRDR TKKKKRSRSR DRNRDRDRDR ERNRDRDHKR
210 220 230 240 250
RHRSRSRSRS RTRERNKVKS RYRSRSRSQS PPKDRKDRDK YGERNLDRWR
260 270 280 290 300
DKHVDRPPPE EPTIGDIYNG KVTSIMQFGC FVQLEGLRKR WEGLVHISEL
310 320 330 340 350
RREGRVANVA DVVSKGQRVK VKVLSFTGTK TSLSMKDVDQ ETGEDLNPNR
360 370 380 390 400
RRNLVGETNE ETSMRNPDRP THLSLVSAPE VEDDSLERKR LTRISDPEKW
410 420 430 440 450
EIKQMIAANV LSKEEFPDFD EETGILPKVD DEEDEDLEIE LVEEEPPFLR
460 470 480 490 500
GHTKQSMDMS PIKIVKNPDG SLSQAAMMQS ALAKERRELK QAQREAEMDS
510 520 530 540 550
IPMGLNKHWV DPLPDAEGRQ IAANMRGIGM MPNDIPEWKK HAFGGNKASY
560 570 580 590 600
GKKTQMSILE QRESLPIYKL KEQLVQAVHD NQILIVIGET GSGKTTQITQ
610 620 630 640 650
YLAEAGYTSR GKIGCTQPRR VAAMSVAKRV SEEFGCCLGQ EVGYTIRFED
660 670 680 690 700
CTSPETVIKY MTDGMLLREC LIDPDLTQYA IIMLDEAHER TIHTDVLFGL
710 720 730 740 750
LKKTVQKRQD MKLIVTSATL DAVKFSQYFY EAPIFTIPGR TYPVEILYTK
760 770 780 790 800
EPETDYLDAS LITVMQIHLT EPPGDILVFL TGQEEIDTAC EILYERMKSL
810 820 830 840 850
GPDVPELIIL PVYSALPSEM QTRIFDPAPP GSRKVVIATN IAETSLTIDG
860 870 880 890 900
IYYVVDPGFV KQKVYNSKTG IDQLVVTPIS QAQAKQRAGR AGRTGPGKCY
910 920 930 940 950
RLYTERAYRD EMLTTNVPEI QRTNLASTVL SLKAMGINDL LSFDFMDAPP
960 970 980 990 1000
METLITAMEQ LYTLGALDDE GLLTRLGRRM AEFPLEPMLC KMLIMSVHLG
1010 1020 1030 1040 1050
CSEEMLTIVS MLSVQNVFYR PKDKQALADQ KKAKFHQTEG DHLTLLAVYN
1060 1070 1080 1090 1100
SWKNNKFSNP WCYENFIQAR SLRRAQDIRK QMLGIMDRHK LDVVSCGKST
1110 1120 1130 1140 1150
VRVQKAICSG FFRNAAKKDP QEGYRTLIDQ QVVYIHPSSA LFNRQPECPK
1160 1170 1180
HFLPVVAVAV SLEQCLSKFE DLNKELGLVT C
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ14562 | DHX8_HUMAN | ATP-dependent RNA helicase DHX8 | DHX8 DDX8 | 1,220 | Annotation score: | ||
K7END7 | K7END7_HUMAN | ATP-dependent RNA helicase DHX8 | DHX8 | 138 | Annotation score: | ||
K7EQH7 | K7EQH7_HUMAN | ATP-dependent RNA helicase DHX8 | DHX8 | 53 | Annotation score: | ||
K7EJH9 | K7EJH9_HUMAN | ATP-dependent RNA helicase DHX8 | DHX8 | 33 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC068675 Genomic DNA No translation available. AC087650 Genomic DNA No translation available. |
RefSeqi | NP_001289552.1, NM_001302623.1 |
Genome annotation databases
Ensembli | ENST00000540306; ENSP00000437886; ENSG00000067596 |
GeneIDi | 1659 |
UCSCi | uc010wig.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC068675 Genomic DNA No translation available. AC087650 Genomic DNA No translation available. |
RefSeqi | NP_001289552.1, NM_001302623.1 |
3D structure databases
SMRi | F5H658 |
ModBasei | Search... |
Proteomic databases
MaxQBi | F5H658 |
PeptideAtlasi | F5H658 |
PRIDEi | F5H658 |
ProteomicsDBi | 27088 |
Protocols and materials databases
Antibodypediai | 29563, 182 antibodies |
Genome annotation databases
Ensembli | ENST00000540306; ENSP00000437886; ENSG00000067596 |
GeneIDi | 1659 |
UCSCi | uc010wig.3, human |
Organism-specific databases
CTDi | 1659 |
EuPathDBi | HostDB:ENSG00000067596.10 |
HGNCi | HGNC:2749, DHX8 |
OpenTargetsi | ENSG00000067596 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155510 |
Miscellaneous databases
BioGRID-ORCSi | 1659, 742 hits in 848 CRISPR screens |
ChiTaRSi | DHX8, human |
GenomeRNAii | 1659 |
Gene expression databases
Bgeei | ENSG00000067596, Expressed in leukocyte and 200 other tissues |
ExpressionAtlasi | F5H658, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR002464, DNA/RNA_helicase_DEAH_CS IPR011709, DUF1605 IPR007502, Helicase-assoc_dom IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR012340, NA-bd_OB-fold IPR027417, P-loop_NTPase IPR022967, S1_dom IPR003029, S1_domain |
Pfami | View protein in Pfam PF04408, HA2, 1 hit PF00271, Helicase_C, 1 hit PF07717, OB_NTP_bind, 1 hit PF00575, S1, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00847, HA2, 1 hit SM00490, HELICc, 1 hit SM00316, S1, 1 hit |
SUPFAMi | SSF50249, SSF50249, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00690, DEAH_ATP_HELICASE, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS50126, S1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F5H658_HUMAN | |
Accessioni | F5H658Primary (citable) accession number: F5H658 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | December 2, 2020 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |