UniProtKB - F5H638 (F5H638_HUMAN)
Protein
Voltage-dependent L-type calcium channel subunit alpha
Gene
CACNA1C
Organism
Homo sapiens (Human)
Status
Functioni
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.UniRule annotation
GO - Molecular functioni
- voltage-gated calcium channel activity Source: InterPro
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Calcium channelUniRule annotationARBA annotation, Ion channel, Voltage-gated channelUniRule annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent L-type calcium channel subunit alphaUniRule annotation |
Gene namesi | Name:CACNA1CImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1390, CACNA1C |
VEuPathDBi | HostDB:ENSG00000151067.20 |
Subcellular locationi
Other locations
- Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
Plasma Membrane
- voltage-gated calcium channel complex Source: InterPro
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 128 – 145 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 165 – 185 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 197 – 215 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 268 – 290 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000151067, Expressed in heart and 182 other tissues |
ExpressionAtlasi | F5H638, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 124 – 370 | Ion_transInterPro annotationAdd BLAST | 247 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 73 – 98 | DisorderedSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156127 |
HOGENOMi | CLU_000540_4_0_1 |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR005451, VDCC_L_a1csu IPR005446, VDCC_L_a1su IPR002077, VDCCAlpha1 IPR027359, Volt_channel_dom_sf |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit |
PRINTSi | PR00167, CACHANNEL PR01630, LVDCCALPHA1 PR01635, LVDCCALPHA1C |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
F5H638-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370
FAMLTVFQCI TMEGWTDVLY W
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ13936 | CAC1C_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C CACH2, CACN2, CACNL1A1, CCHL1A1 | 2,221 | Annotation score: | ||
F5H522 | F5H522_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 2,163 | Annotation score: | ||
A0A0A0MR67 | A0A0A0MR67_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 2,173 | Annotation score: | ||
A0A0A0MSA1 | A0A0A0MSA1_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 2,173 | Annotation score: | ||
E9PDI6 | E9PDI6_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 2,209 | Annotation score: | ||
F5GY28 | F5GY28_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 2,209 | Annotation score: | ||
A0A087WUX4 | A0A087WUX4_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 243 | Annotation score: | ||
A0A5F9ZHD9 | A0A5F9ZHD9_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 125 | Annotation score: | ||
F5H0X0 | F5H0X0_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 100 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005293 Genomic DNA No translation available. AC005342 Genomic DNA No translation available. AC005344 Genomic DNA No translation available. AC005414 Genomic DNA No translation available. AC005866 Genomic DNA No translation available. AC006051 Genomic DNA No translation available. KF455573 Genomic DNA No translation available. KF455574 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000480911; ENSP00000437936; ENSG00000151067 |
UCSCi | uc058juf.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005293 Genomic DNA No translation available. AC005342 Genomic DNA No translation available. AC005344 Genomic DNA No translation available. AC005414 Genomic DNA No translation available. AC005866 Genomic DNA No translation available. AC006051 Genomic DNA No translation available. KF455573 Genomic DNA No translation available. KF455574 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | F5H638 |
ProteomicsDBi | 27069 |
Genome annotation databases
Ensembli | ENST00000480911; ENSP00000437936; ENSG00000151067 |
UCSCi | uc058juf.1, human |
Organism-specific databases
HGNCi | HGNC:1390, CACNA1C |
OpenTargetsi | ENSG00000151067 |
VEuPathDBi | HostDB:ENSG00000151067.20 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156127 |
HOGENOMi | CLU_000540_4_0_1 |
Miscellaneous databases
ChiTaRSi | CACNA1C, human |
Gene expression databases
Bgeei | ENSG00000151067, Expressed in heart and 182 other tissues |
ExpressionAtlasi | F5H638, baseline and differential |
Family and domain databases
Gene3Di | 1.20.120.350, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR005451, VDCC_L_a1csu IPR005446, VDCC_L_a1su IPR002077, VDCCAlpha1 IPR027359, Volt_channel_dom_sf |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit |
PRINTSi | PR00167, CACHANNEL PR01630, LVDCCALPHA1 PR01635, LVDCCALPHA1C |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F5H638_HUMAN | |
Accessioni | F5H638Primary (citable) accession number: F5H638 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | December 11, 2019 | |
Last modified: | February 10, 2021 | |
This is version 68 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |