UniProtKB - F5H5Q2 (F5H5Q2_HUMAN)
Protein
Submitted name:
Activin receptor type-1B
Gene
ACVR1B
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
Protein has several cofactor binding sites:GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- transmembrane receptor protein serine/threonine kinase activity Source: InterPro
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinaseARBA annotation, Transferase |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: Activin receptor type-1BImported |
Gene namesi | Name:ACVR1BImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:172, ACVR1B |
VEuPathDBi | HostDB:ENSG00000135503.12 |
Subcellular locationi
Other locations
- membrane Source: UniProtKB-KW
Keywords - Cellular componenti
MembraneARBA annotationPTM / Processingi
Proteomic databases
PaxDbi | F5H5Q2 |
PeptideAtlasi | F5H5Q2 |
PRIDEi | F5H5Q2 |
ProteomicsDBi | 26947 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135503, Expressed in secondary oocyte and 241 other tissues |
ExpressionAtlasi | F5H5Q2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 51 | Activin_recpInterPro annotationAdd BLAST | 44 |
Keywords - Domaini
SignalARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000157032 |
HOGENOMi | CLU_2746583_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR000472, Activin_recp IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
F5H5Q2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSIFNLDGM EHHVRTCIPK VELVPAGKPF YCLSSEDLRN THCCYTDYCN
60 70
RIDLRVPSGH LKEPEHPSMW G
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketP36896 | ACV1B_HUMAN | Activin receptor type-1B | ACVR1B ACVRLK4, ALK4 | 505 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 71 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC025259 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000536420; ENSP00000443218; ENSG00000135503 |
UCSCi | uc058oeu.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC025259 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PaxDbi | F5H5Q2 |
PeptideAtlasi | F5H5Q2 |
PRIDEi | F5H5Q2 |
ProteomicsDBi | 26947 |
Protocols and materials databases
Antibodypediai | 14450, 524 antibodies |
Genome annotation databases
Ensembli | ENST00000536420; ENSP00000443218; ENSG00000135503 |
UCSCi | uc058oeu.1, human |
Organism-specific databases
HGNCi | HGNC:172, ACVR1B |
OpenTargetsi | ENSG00000135503 |
VEuPathDBi | HostDB:ENSG00000135503.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000157032 |
HOGENOMi | CLU_2746583_0_0_1 |
Miscellaneous databases
ChiTaRSi | ACVR1B, human |
Gene expression databases
Bgeei | ENSG00000135503, Expressed in secondary oocyte and 241 other tissues |
ExpressionAtlasi | F5H5Q2, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000472, Activin_recp IPR000333, TGFB_receptor |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF01064, Activin_recp, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F5H5Q2_HUMAN | |
Accessioni | F5H5Q2Primary (citable) accession number: F5H5Q2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | February 10, 2021 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |