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UniProtKB - F5H522 (F5H522_HUMAN)
Protein
Voltage-dependent L-type calcium channel subunit alpha
Gene
CACNA1C
Organism
Homo sapiens (Human)
Status
Functioni
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.
UniRule annotationGO - Molecular functioni
- calmodulin binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- voltage-gated calcium channel activity Source: InterPro
GO - Biological processi
- regulation of ion transmembrane transport Source: UniProtKB-KW
Keywordsi
Molecular function | Calcium channelUniRule annotationARBA annotation, Calmodulin-bindingARBA annotation, Ion channel, Voltage-gated channelUniRule annotationARBA annotation |
Biological process | Calcium transport, Ion transport, Transport |
Ligand | Calcium, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Voltage-dependent L-type calcium channel subunit alphaUniRule annotation |
Gene namesi | Name:CACNA1C |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1390, CACNA1C |
VEuPathDBi | HostDB:ENSG00000151067 |
Subcellular locationi
Plasma membrane
- postsynaptic density membrane ARBA annotation
- T-tubule ARBA annotation
- sarcolemma ARBA annotation; Multi-pass membrane protein ARBA annotation
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- dendrite ARBA annotation
- Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
- Perikaryon ARBA annotation
Plasma Membrane
- postsynaptic density membrane Source: UniProtKB-SubCell
- T-tubule Source: UniProtKB-SubCell
- voltage-gated calcium channel complex Source: InterPro
Other locations
- dendrite Source: UniProtKB-SubCell
- perikaryon Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 128 – 145 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 165 – 185 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 197 – 215 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 268 – 290 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 349 – 370 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 382 – 404 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 550 – 568 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 676 – 698 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 752 – 778 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 926 – 945 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 957 – 979 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 999 – 1022 | HelicalSequence analysisAdd BLAST | 24 | |
Transmembranei | 1043 – 1076 | HelicalSequence analysisAdd BLAST | 34 | |
Transmembranei | 1168 – 1194 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 1245 – 1266 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 1278 – 1298 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1384 – 1402 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 1478 – 1501 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
Cell junction, Cell membraneARBA annotation, Cell projectionARBA annotation, Membrane, Postsynaptic cell membraneARBA annotation, SynapseExpressioni
Gene expression databases
Bgeei | ENSG00000151067, Expressed in heart and 182 other tissues |
ExpressionAtlasi | F5H522, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1635 – 1669 | Ca_chan_IQInterPro annotationAdd BLAST | 35 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 20 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 73 – 98 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 448 – 468 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 789 – 886 | DisorderedSequence analysisAdd BLAST | 98 | |
Regioni | 1755 – 1824 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 1971 – 2005 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 2128 – 2163 | DisorderedSequence analysisAdd BLAST | 36 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1596 – 1616 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 789 – 834 | Basic and acidic residuesSequence analysisAdd BLAST | 46 | |
Compositional biasi | 1755 – 1800 | Polar residuesSequence analysisAdd BLAST | 46 | |
Compositional biasi | 1974 – 1991 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 2130 – 2154 | Basic and acidic residuesSequence analysisAdd BLAST | 25 |
Sequence similaritiesi
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily. [View classification]ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156127 |
OrthoDBi | 172471at2759 |
Family and domain databases
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR031688, CAC1F_C IPR031649, GPHH_dom IPR005821, Ion_trans_dom IPR014873, VDCC_a1su_IQ IPR005451, VDCC_L_a1csu IPR005446, VDCC_L_a1su IPR002077, VDCCAlpha1 IPR027359, Volt_channel_dom_sf |
Pfami | View protein in Pfam PF08763, Ca_chan_IQ, 1 hit PF16885, CAC1F_C, 2 hits PF16905, GPHH, 1 hit PF00520, Ion_trans, 4 hits |
PRINTSi | PR00167, CACHANNEL PR01630, LVDCCALPHA1 PR01635, LVDCCALPHA1C |
SMARTi | View protein in SMART SM01062, Ca_chan_IQ, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 19 potential isoforms that are computationally mapped.Show allAlign All
F5H522-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL
60 70 80 90 100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP
110 120 130 140 150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED
160 170 180 190 200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF
210 220 230 240 250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG
260 270 280 290 300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN
310 320 330 340 350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA
360 370 380 390 400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV
410 420 430 440 450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE
460 470 480 490 500
NEDEGMDEEK PRNRGTPAGM LDQKKGKFAW FSHSTETHVS MPTSETESVN
510 520 530 540 550
TENVAGGDIE GENCGARLAH RISKSKFSRY WRRWNRFCRR KCRAAVKSNV
560 570 580 590 600
FYWLVIFLVF LNTLTIASEH YNQPNWLTEV QDTANKALLA LFTAEMLLKM
610 620 630 640 650
YSLGLQAYFV SLFNRFDCFV VCGGILETIL VETKIMSPLG ISVLRCVRLL
660 670 680 690 700
RIFKITRYWN SLSNLVASLL NSVRSIASLL LLLFLFIIIF SLLGMQLFGG
710 720 730 740 750
KFNFDEMQTR RSTFDNFPQS LLTVFQILTG EDWNSVMYDG IMAYGGPSFP
760 770 780 790 800
GMLVCIYFII LFICGNYILL NVFLAIAVDN LADAESLTSA QKEEEEEKER
810 820 830 840 850
KKLARTASPE KKQELVEKPA VGESKEEKIE LKSITADGES PPATKINMDD
860 870 880 890 900
LQPNENEDKS PYPNPETTGE EDEEEPEMPV GPRPRPLSEL HLKEKAVPMP
910 920 930 940 950
EASAFFIFSS NNRFRLQCHR IVNDTIFTNL ILFFILLSSI SLAAEDPVQH
960 970 980 990 1000
TSFRNHILFY FDIVFTTIFT IEIALKMTAY GAFLHKGSFC RNYFNILDLL
1010 1020 1030 1040 1050
VVSVSLISFG IQSSAINVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA
1060 1070 1080 1090 1100
IRTIGNIVIV TTLLQFMFAC IGVQLFKGKL YTCSDSSKQT EAECKGNYIT
1110 1120 1130 1140 1150
YKDGEVDHPI IQPRSWENSK FDFDNVLAAM MALFTVSTFE GWPELLYRSI
1160 1170 1180 1190 1200
DSHTEDKGPI YNYRVEISIF FIIYIIIIAF FMMNIFVGFV IVTFQEQGEQ
1210 1220 1230 1240 1250
EYKNCELDKN QRQCVEYALK ARPLRRYIPK NQHQYKVWYV VNSTYFEYLM
1260 1270 1280 1290 1300
FVLILLNTIC LAMQHYGQSC LFKIAMNILN MLFTGLFTVE MILKLIAFKP
1310 1320 1330 1340 1350
KHYFCDAWNT FDALIVVGSI VDIAITEVNP AEHTQCSPSM NAEENSRISI
1360 1370 1380 1390 1400
TFFRLFRVMR LVKLLSRGEG IRTLLWTFIK SFQALPYVAL LIVMLFFIYA
1410 1420 1430 1440 1450
VIGMQVFGKI ALNDTTEINR NNNFQTFPQA VLLLFRCATG EAWQDIMLAC
1460 1470 1480 1490 1500
MPGKKCAPES EPSNSTEGET PCGSSFAVFY FISFYMLCAF LIINLFVAVI
1510 1520 1530 1540 1550
MDNFDYLTRD WSILGPHHLD EFKRIWAEYD PEAKGRIKHL DVVTLLRRIQ
1560 1570 1580 1590 1600
PPLGFGKLCP HRVACKRLVS MNMPLNSDGT VMFNATLFAL VRTALRIKTE
1610 1620 1630 1640 1650
GNLEQANEEL RAIIKKIWKR TSMKLLDQVV PPAGDDEVTV GKFYATFLIQ
1660 1670 1680 1690 1700
EYFRKFKKRK EQGLVGKPSQ RNALSLQAGL RTLHDIGPEI RRAISGDLTA
1710 1720 1730 1740 1750
EEELDKAMKE AVSAASEDDI FRRAGGLFGN HVSYYQSDGR SAFPQTFTTQ
1760 1770 1780 1790 1800
RPLHINKAGS SQGDTESPSH EKLVDSTFTP SSYSSTGSNA NINNANNTAL
1810 1820 1830 1840 1850
GRLPRPAGYP STVSTVEGHG PPLSPAIRVQ EVAWKLSSNR CHSRESQAAM
1860 1870 1880 1890 1900
AGQEETSQDE TYEVKMNHDT EACSEPSLLS TEMLSYQDDE NRQLTLPEED
1910 1920 1930 1940 1950
KRDIRQSPKR GFLRSASLGR RASFHLECLK RQKDRGGDIS QKTVLPLHLV
1960 1970 1980 1990 2000
HHQALAVAGL SPLLQRSHSP ASFPRPFATP PATPGSRGWP PQPVPTLRLE
2010 2020 2030 2040 2050
GVESSEKLNS SFPSIHCGSW AETTPGGGGS SAARRVRPVS LMVPSQAGAP
2060 2070 2080 2090 2100
GRQFHGSASS LVEAVLISEG LGQFAQDPKF IEVTTQELAD ACDMTIEEME
2110 2120 2130 2140 2150
SAADNILSGG APQSPNGALL PFVNCRDAGQ DRAGGEEDAG CVRARGRPSE
2160
EELQDSRVYV SSL
Computationally mapped potential isoform sequencesi
There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ13936 | CAC1C_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C CACH2, CACN2, CACNL1A1, CCHL1A1 | 2,221 | Annotation score: | ||
A0A0A0MR67 | A0A0A0MR67_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 2,173 | Annotation score: | ||
A0A0A0MSA1 | A0A0A0MSA1_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 2,173 | Annotation score: | ||
E9PDI6 | E9PDI6_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 2,198 | Annotation score: | ||
F5GY28 | F5GY28_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 2,209 | Annotation score: | ||
F5H638 | F5H638_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 371 | Annotation score: | ||
A0A804HI37 | A0A804HI37_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 2,168 | Annotation score: | ||
A0A804HIJ8 | A0A804HIJ8_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 2,168 | Annotation score: | ||
A0A804HJB6 | A0A804HJB6_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 2,168 | Annotation score: | ||
A0A804HKC4 | A0A804HKC4_HUMAN | Voltage-dependent L-type calcium ch... | CACNA1C | 2,193 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005293 Genomic DNA No translation available. AC005342 Genomic DNA No translation available. AC005344 Genomic DNA No translation available. AC005414 Genomic DNA No translation available. AC005866 Genomic DNA No translation available. AC006051 Genomic DNA No translation available. KF455573 Genomic DNA No translation available. KF455574 Genomic DNA No translation available. |
RefSeqi | XP_011519325.1, XM_011521023.2 |
Genome annotation databases
Ensembli | ENST00000335762.10; ENSP00000336982.5; ENSG00000151067.23 |
GeneIDi | 775 |
UCSCi | uc001qkv.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005293 Genomic DNA No translation available. AC005342 Genomic DNA No translation available. AC005344 Genomic DNA No translation available. AC005414 Genomic DNA No translation available. AC005866 Genomic DNA No translation available. AC006051 Genomic DNA No translation available. KF455573 Genomic DNA No translation available. KF455574 Genomic DNA No translation available. |
RefSeqi | XP_011519325.1, XM_011521023.2 |
3D structure databases
SMRi | F5H522 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | F5H522 |
PRIDEi | F5H522 |
ProteomicsDBi | 26746 |
Protocols and materials databases
Antibodypediai | 22118, 520 antibodies from 40 providers |
DNASUi | 775 |
Genome annotation databases
Ensembli | ENST00000335762.10; ENSP00000336982.5; ENSG00000151067.23 |
GeneIDi | 775 |
UCSCi | uc001qkv.2, human |
Organism-specific databases
CTDi | 775 |
HGNCi | HGNC:1390, CACNA1C |
OpenTargetsi | ENSG00000151067 |
VEuPathDBi | HostDB:ENSG00000151067 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156127 |
OrthoDBi | 172471at2759 |
Miscellaneous databases
BioGRID-ORCSi | 775, 13 hits in 1073 CRISPR screens |
ChiTaRSi | CACNA1C, human |
GenomeRNAii | 775 |
Gene expression databases
Bgeei | ENSG00000151067, Expressed in heart and 182 other tissues |
ExpressionAtlasi | F5H522, baseline and differential |
Family and domain databases
Gene3Di | 1.20.120.350, 4 hits |
InterProi | View protein in InterPro IPR031688, CAC1F_C IPR031649, GPHH_dom IPR005821, Ion_trans_dom IPR014873, VDCC_a1su_IQ IPR005451, VDCC_L_a1csu IPR005446, VDCC_L_a1su IPR002077, VDCCAlpha1 IPR027359, Volt_channel_dom_sf |
Pfami | View protein in Pfam PF08763, Ca_chan_IQ, 1 hit PF16885, CAC1F_C, 2 hits PF16905, GPHH, 1 hit PF00520, Ion_trans, 4 hits |
PRINTSi | PR00167, CACHANNEL PR01630, LVDCCALPHA1 PR01635, LVDCCALPHA1C |
SMARTi | View protein in SMART SM01062, Ca_chan_IQ, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F5H522_HUMAN | |
Accessioni | F5H522Primary (citable) accession number: F5H522 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | May 25, 2022 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |