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UniProtKB - F5H522 (F5H522_HUMAN)

Entry version 77 (25 May 2022)
Sequence version 1 (28 Jun 2011)
Previous versions | rss
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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

CACNA1C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.

UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotationARBA annotation, Calmodulin-bindingARBA annotation, Ion channel, Voltage-gated channelUniRule annotationARBA annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CACNA1C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1390, CACNA1C

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000151067

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei128 – 145HelicalSequence analysisAdd BLAST18
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei197 – 215HelicalSequence analysisAdd BLAST19
Transmembranei268 – 290HelicalSequence analysisAdd BLAST23
Transmembranei349 – 370HelicalSequence analysisAdd BLAST22
Transmembranei382 – 404HelicalSequence analysisAdd BLAST23
Transmembranei550 – 568HelicalSequence analysisAdd BLAST19
Transmembranei676 – 698HelicalSequence analysisAdd BLAST23
Transmembranei752 – 778HelicalSequence analysisAdd BLAST27
Transmembranei926 – 945HelicalSequence analysisAdd BLAST20
Transmembranei957 – 979HelicalSequence analysisAdd BLAST23
Transmembranei999 – 1022HelicalSequence analysisAdd BLAST24
Transmembranei1043 – 1076HelicalSequence analysisAdd BLAST34
Transmembranei1168 – 1194HelicalSequence analysisAdd BLAST27
Transmembranei1245 – 1266HelicalSequence analysisAdd BLAST22
Transmembranei1278 – 1298HelicalSequence analysisAdd BLAST21
Transmembranei1384 – 1402HelicalSequence analysisAdd BLAST19
Transmembranei1478 – 1501HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membraneARBA annotation, Cell projectionARBA annotation, Membrane, Postsynaptic cell membraneARBA annotation, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000151067

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		F5H522

PRoteomics IDEntifications database

More...PRIDEi		F5H522

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		26746

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000151067, Expressed in heart and 182 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F5H522, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		F5H522

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1635 – 1669Ca_chan_IQInterPro annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni73 – 98DisorderedSequence analysisAdd BLAST26
Regioni448 – 468DisorderedSequence analysisAdd BLAST21
Regioni789 – 886DisorderedSequence analysisAdd BLAST98
Regioni1755 – 1824DisorderedSequence analysisAdd BLAST70
Regioni1971 – 2005DisorderedSequence analysisAdd BLAST35
Regioni2128 – 2163DisorderedSequence analysisAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1596 – 1616Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi789 – 834Basic and acidic residuesSequence analysisAdd BLAST46
Compositional biasi1755 – 1800Polar residuesSequence analysisAdd BLAST46
Compositional biasi1974 – 1991Pro residuesSequence analysisAdd BLAST18
Compositional biasi2130 – 2154Basic and acidic residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1C subfamily. [View classification]ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156127

Database of Orthologous Groups

More...OrthoDBi		172471at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031688, CAC1F_C
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005451, VDCC_L_a1csu
IPR005446, VDCC_L_a1su
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16885, CAC1F_C, 2 hits
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00167, CACHANNEL
PR01630, LVDCCALPHA1
PR01635, LVDCCALPHA1C

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01062, Ca_chan_IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 19 potential isoforms that are computationally mapped.Show allAlign All

F5H522-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNENTRMYI PEENHQGSNY GSPRPAHANM NANAAAGLAP EHIPTPGAAL 
        60         70         80         90        100
SWQAAIDAAR QAKLMGSAGN ATISTVSSTQ RKRQQYGKPK KQGSTTATRP 
       110        120        130        140        150
PRALLCLTLK NPIRRACISI VEWKPFEIII LLTIFANCVA LAIYIPFPED 
       160        170        180        190        200
DSNATNSNLE RVEYLFLIIF TVEAFLKVIA YGLLFHPNAY LRNGWNLLDF 
       210        220        230        240        250
IIVVVGLFSA ILEQATKADG ANALGGKGAG FDVKALRAFR VLRPLRLVSG 
       260        270        280        290        300
VPSLQVVLNS IIKAMVPLLH IALLVLFVII IYAIIGLELF MGKMHKTCYN 
       310        320        330        340        350
QEGIADVPAE DDPSPCALET GHGRQCQNGT VCKPGWDGPK HGITNFDNFA 
       360        370        380        390        400
FAMLTVFQCI TMEGWTDVLY WVNDAVGRDW PWIYFVTLII IGSFFVLNLV 
       410        420        430        440        450
LGVLSGEFSK EREKAKARGD FQKLREKQQL EEDLKGYLDW ITQAEDIDPE 
       460        470        480        490        500
NEDEGMDEEK PRNRGTPAGM LDQKKGKFAW FSHSTETHVS MPTSETESVN 
       510        520        530        540        550
TENVAGGDIE GENCGARLAH RISKSKFSRY WRRWNRFCRR KCRAAVKSNV 
       560        570        580        590        600
FYWLVIFLVF LNTLTIASEH YNQPNWLTEV QDTANKALLA LFTAEMLLKM 
       610        620        630        640        650
YSLGLQAYFV SLFNRFDCFV VCGGILETIL VETKIMSPLG ISVLRCVRLL 
       660        670        680        690        700
RIFKITRYWN SLSNLVASLL NSVRSIASLL LLLFLFIIIF SLLGMQLFGG 
       710        720        730        740        750
KFNFDEMQTR RSTFDNFPQS LLTVFQILTG EDWNSVMYDG IMAYGGPSFP 
       760        770        780        790        800
GMLVCIYFII LFICGNYILL NVFLAIAVDN LADAESLTSA QKEEEEEKER 
       810        820        830        840        850
KKLARTASPE KKQELVEKPA VGESKEEKIE LKSITADGES PPATKINMDD 
       860        870        880        890        900
LQPNENEDKS PYPNPETTGE EDEEEPEMPV GPRPRPLSEL HLKEKAVPMP 
       910        920        930        940        950
EASAFFIFSS NNRFRLQCHR IVNDTIFTNL ILFFILLSSI SLAAEDPVQH 
       960        970        980        990       1000
TSFRNHILFY FDIVFTTIFT IEIALKMTAY GAFLHKGSFC RNYFNILDLL 
      1010       1020       1030       1040       1050
VVSVSLISFG IQSSAINVVK ILRVLRVLRP LRAINRAKGL KHVVQCVFVA 
      1060       1070       1080       1090       1100
IRTIGNIVIV TTLLQFMFAC IGVQLFKGKL YTCSDSSKQT EAECKGNYIT 
      1110       1120       1130       1140       1150
YKDGEVDHPI IQPRSWENSK FDFDNVLAAM MALFTVSTFE GWPELLYRSI 
      1160       1170       1180       1190       1200
DSHTEDKGPI YNYRVEISIF FIIYIIIIAF FMMNIFVGFV IVTFQEQGEQ 
      1210       1220       1230       1240       1250
EYKNCELDKN QRQCVEYALK ARPLRRYIPK NQHQYKVWYV VNSTYFEYLM 
      1260       1270       1280       1290       1300
FVLILLNTIC LAMQHYGQSC LFKIAMNILN MLFTGLFTVE MILKLIAFKP 
      1310       1320       1330       1340       1350
KHYFCDAWNT FDALIVVGSI VDIAITEVNP AEHTQCSPSM NAEENSRISI 
      1360       1370       1380       1390       1400
TFFRLFRVMR LVKLLSRGEG IRTLLWTFIK SFQALPYVAL LIVMLFFIYA 
      1410       1420       1430       1440       1450
VIGMQVFGKI ALNDTTEINR NNNFQTFPQA VLLLFRCATG EAWQDIMLAC 
      1460       1470       1480       1490       1500
MPGKKCAPES EPSNSTEGET PCGSSFAVFY FISFYMLCAF LIINLFVAVI 
      1510       1520       1530       1540       1550
MDNFDYLTRD WSILGPHHLD EFKRIWAEYD PEAKGRIKHL DVVTLLRRIQ 
      1560       1570       1580       1590       1600
PPLGFGKLCP HRVACKRLVS MNMPLNSDGT VMFNATLFAL VRTALRIKTE 
      1610       1620       1630       1640       1650
GNLEQANEEL RAIIKKIWKR TSMKLLDQVV PPAGDDEVTV GKFYATFLIQ 
      1660       1670       1680       1690       1700
EYFRKFKKRK EQGLVGKPSQ RNALSLQAGL RTLHDIGPEI RRAISGDLTA 
      1710       1720       1730       1740       1750
EEELDKAMKE AVSAASEDDI FRRAGGLFGN HVSYYQSDGR SAFPQTFTTQ 
      1760       1770       1780       1790       1800
RPLHINKAGS SQGDTESPSH EKLVDSTFTP SSYSSTGSNA NINNANNTAL 
      1810       1820       1830       1840       1850
GRLPRPAGYP STVSTVEGHG PPLSPAIRVQ EVAWKLSSNR CHSRESQAAM 
      1860       1870       1880       1890       1900
AGQEETSQDE TYEVKMNHDT EACSEPSLLS TEMLSYQDDE NRQLTLPEED 
      1910       1920       1930       1940       1950
KRDIRQSPKR GFLRSASLGR RASFHLECLK RQKDRGGDIS QKTVLPLHLV 
      1960       1970       1980       1990       2000
HHQALAVAGL SPLLQRSHSP ASFPRPFATP PATPGSRGWP PQPVPTLRLE 
      2010       2020       2030       2040       2050
GVESSEKLNS SFPSIHCGSW AETTPGGGGS SAARRVRPVS LMVPSQAGAP 
      2060       2070       2080       2090       2100
GRQFHGSASS LVEAVLISEG LGQFAQDPKF IEVTTQELAD ACDMTIEEME 
      2110       2120       2130       2140       2150
SAADNILSGG APQSPNGALL PFVNCRDAGQ DRAGGEEDAG CVRARGRPSE 
      2160 
EELQDSRVYV SSL
Length:2,163
Mass (Da):242,406
Last modified:June 28, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD56176EEDFCAA0CC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q13936CAC1C_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1C CACH2, CACN2, CACNL1A1, CCHL1A1
2,221Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MR67A0A0A0MR67_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1C
2,173Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MSA1A0A0A0MSA1_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1C
2,173Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PDI6E9PDI6_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1C
2,198Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GY28F5GY28_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1C
2,209Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H638F5H638_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1C
371Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HI37A0A804HI37_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1C
2,168Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HIJ8A0A804HIJ8_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1C
2,168Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HJB6A0A804HJB6_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1C
2,168Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A804HKC4A0A804HKC4_HUMAN
Voltage-dependent L-type calcium ch...
CACNA1C
2,193Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC005293 Genomic DNA No translation available.
AC005342 Genomic DNA No translation available.
AC005344 Genomic DNA No translation available.
AC005414 Genomic DNA No translation available.
AC005866 Genomic DNA No translation available.
AC006051 Genomic DNA No translation available.
KF455573 Genomic DNA No translation available.
KF455574 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_011519325.1, XM_011521023.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000335762.10; ENSP00000336982.5; ENSG00000151067.23

Database of genes from NCBI RefSeq genomes

More...GeneIDi		775

UCSC genome browser

More...UCSCi		uc001qkv.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005293 Genomic DNA No translation available.
AC005342 Genomic DNA No translation available.
AC005344 Genomic DNA No translation available.
AC005414 Genomic DNA No translation available.
AC005866 Genomic DNA No translation available.
AC006051 Genomic DNA No translation available.
KF455573 Genomic DNA No translation available.
KF455574 Genomic DNA No translation available.
RefSeqiXP_011519325.1, XM_011521023.2

3D structure databases

SMRiF5H522
ModBaseiSearch...

Proteomic databases

PeptideAtlasiF5H522
PRIDEiF5H522
ProteomicsDBi26746

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22118, 520 antibodies from 40 providers

The DNASU plasmid repository

More...DNASUi		775

Genome annotation databases

EnsembliENST00000335762.10; ENSP00000336982.5; ENSG00000151067.23
GeneIDi775
UCSCiuc001qkv.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		775
HGNCiHGNC:1390, CACNA1C
OpenTargetsiENSG00000151067
VEuPathDBiHostDB:ENSG00000151067

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000156127
OrthoDBi172471at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		775, 13 hits in 1073 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CACNA1C, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		775

Gene expression databases

BgeeiENSG00000151067, Expressed in heart and 182 other tissues
ExpressionAtlasiF5H522, baseline and differential

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031688, CAC1F_C
IPR031649, GPHH_dom
IPR005821, Ion_trans_dom
IPR014873, VDCC_a1su_IQ
IPR005451, VDCC_L_a1csu
IPR005446, VDCC_L_a1su
IPR002077, VDCCAlpha1
IPR027359, Volt_channel_dom_sf
PfamiView protein in Pfam
PF08763, Ca_chan_IQ, 1 hit
PF16885, CAC1F_C, 2 hits
PF16905, GPHH, 1 hit
PF00520, Ion_trans, 4 hits
PRINTSiPR00167, CACHANNEL
PR01630, LVDCCALPHA1
PR01635, LVDCCALPHA1C
SMARTiView protein in SMART
SM01062, Ca_chan_IQ, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF5H522_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F5H522
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 25, 2022
This is version 77 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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