UniProtKB - F5H4E2 (F5H4E2_HUMAN)
Protein
Submitted name:
SPARC
Gene
SPARC
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- calcium ion binding Source: InterPro
- collagen binding Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: SPARCImported |
Gene namesi | Name:SPARCImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11219, SPARC |
VEuPathDBi | HostDB:ENSG00000113140.10 |
Subcellular locationi
Extracellular region or secreted
- collagen-containing extracellular matrix Source: InterPro
- extracellular space Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5003327259 | 18 – 111 | Sequence analysisAdd BLAST | 94 |
Proteomic databases
MaxQBi | F5H4E2 |
PeptideAtlasi | F5H4E2 |
PRIDEi | F5H4E2 |
ProteomicsDBi | 26545 |
Expressioni
Gene expression databases
Bgeei | ENSG00000113140, Expressed in tibia and 242 other tissues |
ExpressionAtlasi | F5H4E2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 71 – 94 | Follistatin-likeInterPro annotationAdd BLAST | 24 |
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00510000046787 |
HOGENOMi | CLU_2189844_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR003645, Fol_N IPR015369, Follistatin/Osteonectin_EGF IPR001999, Osteonectin_CS IPR037641, SPARC |
PANTHERi | PTHR13866:SF6, PTHR13866:SF6, 1 hit |
Pfami | View protein in Pfam PF09289, FOLN, 1 hit |
SMARTi | View protein in SMART SM00274, FOLN, 1 hit |
PROSITEi | View protein in PROSITE PS00612, OSTEONECTIN_1, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
F5H4E2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRAWIFFLLC LAGRALAAPQ QEALPDETEV VEETVAEVTE VSVGANPVQV
60 70 80 90 100
EVGEFDDGAE ETEEEVVAEN PCQNHHCKHG KVCELDENNT PMCVCQDPTS
110
CPAPIGEFEK V
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP09486 | SPRC_HUMAN | SPARC | SPARC ON | 303 | Annotation score: | ||
F5GY03 | F5GY03_HUMAN | Osteonectin | SPARC | 149 | Annotation score: | ||
E5RK62 | E5RK62_HUMAN | Osteonectin | SPARC | 115 | Annotation score: | ||
E5RJA5 | E5RJA5_HUMAN | SPARC | SPARC | 53 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 111 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011374 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000539687; ENSP00000444998; ENSG00000113140 |
UCSCi | uc063ivv.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011374 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | F5H4E2 |
PeptideAtlasi | F5H4E2 |
PRIDEi | F5H4E2 |
ProteomicsDBi | 26545 |
Protocols and materials databases
Antibodypediai | 878, 758 antibodies |
Genome annotation databases
Ensembli | ENST00000539687; ENSP00000444998; ENSG00000113140 |
UCSCi | uc063ivv.1, human |
Organism-specific databases
HGNCi | HGNC:11219, SPARC |
OpenTargetsi | ENSG00000113140 |
VEuPathDBi | HostDB:ENSG00000113140.10 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00510000046787 |
HOGENOMi | CLU_2189844_0_0_1 |
Miscellaneous databases
ChiTaRSi | SPARC, human |
Gene expression databases
Bgeei | ENSG00000113140, Expressed in tibia and 242 other tissues |
ExpressionAtlasi | F5H4E2, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR003645, Fol_N IPR015369, Follistatin/Osteonectin_EGF IPR001999, Osteonectin_CS IPR037641, SPARC |
PANTHERi | PTHR13866:SF6, PTHR13866:SF6, 1 hit |
Pfami | View protein in Pfam PF09289, FOLN, 1 hit |
SMARTi | View protein in SMART SM00274, FOLN, 1 hit |
PROSITEi | View protein in PROSITE PS00612, OSTEONECTIN_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F5H4E2_HUMAN | |
Accessioni | F5H4E2Primary (citable) accession number: F5H4E2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | February 10, 2021 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |