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Protein
Submitted name:

Sodium/potassium/calcium exchanger 1

Gene

SLC24A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Sodium/potassium/calcium exchanger 1Imported
Gene namesi
Name:SLC24A1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000074621.13
HGNCiHGNC:10975 SLC24A1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Transmembranei454 – 473HelicalSequence analysisAdd BLAST20
Transmembranei494 – 518HelicalSequence analysisAdd BLAST25
Transmembranei524 – 546HelicalSequence analysisAdd BLAST23
Transmembranei558 – 576HelicalSequence analysisAdd BLAST19
Transmembranei582 – 599HelicalSequence analysisAdd BLAST18
Transmembranei822 – 846HelicalSequence analysisAdd BLAST25
Transmembranei858 – 880HelicalSequence analysisAdd BLAST23
Transmembranei887 – 910HelicalSequence analysisAdd BLAST24
Transmembranei922 – 943HelicalSequence analysisAdd BLAST22
Transmembranei955 – 974HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000074621

PTM / Processingi

Proteomic databases

PeptideAtlasiF5H483
PRIDEiF5H483

Expressioni

Gene expression databases

BgeeiENSG00000074621
ExpressionAtlasiF5H483 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5H483
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini459 – 599Na_Ca_exInterPro annotationAdd BLAST141
Domaini823 – 972Na_Ca_exInterPro annotationAdd BLAST150

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili742 – 781Sequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. [View classification]SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119209

Family and domain databases

InterProiView protein in InterPro
IPR004481 K/Na/Ca-exchanger
IPR004837 NaCa_Exmemb
IPR004817 SLC24A1
PANTHERiPTHR10846 PTHR10846, 2 hits
PfamiView protein in Pfam
PF01699 Na_Ca_ex, 2 hits
TIGRFAMsiTIGR00927 2A1904, 1 hit
TIGR00367 TIGR00367, 1 hit

Sequencei

Sequence statusi: Complete.

F5H483-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKLIRMGPQ ERWLLRTKRL HWSRLLFLLG MLIIGSTYQH LRRPRGLSSL
60 70 80 90 100
WAAVSSHQPI KLASRDLSSE EMMMMSSSPS KPSSEMGGKM LVPQASVGSD
110 120 130 140 150
EATLSMTVEN IPSMPKRTAK MIPTTTKNNY SPTAAGTERR KEDTPTSSRT
160 170 180 190 200
LTYYTSTSSR QIVKKYTPTP RGEMKSYSPT QVREKVKYTP SPRGRRVGTY
210 220 230 240 250
VPSTFMTMET SHAITPRTTV KDSDITATYK ILETNSLKRI MEETTPTTLK
260 270 280 290 300
GMFDSTPTFL THEVEANVLT SPRSVMEKNN LFPPRRVESN SSAHPWGLVG
310 320 330 340 350
KSNPKTPQGT VLLHTPATSE GQVTISTMTG SSPAETKAFT AAWSLRNPSP
360 370 380 390 400
RTSVSAIKTA PAIVWRLAKK PSTAPSTSTT PTVRAKLTMQ VHHCVVVKPT
410 420 430 440 450
PAMLTTPSPS LTTALLPEEL SPSPSVLPPS LPDLHPKGEY PPDLFSVEER
460 470 480 490 500
RQGWVVLHVF GMMYVFVALA IVCDEYFVPA LGVITDKLQI SEDVAGATFM
510 520 530 540 550
AAGGSAPELF TSLIGVFISH SNVGIGTIVG SAVFNILFVI GTCSLFSREI
560 570 580 590 600
LNLTWWPLFR DVSFYILDLI MLILFFLDSL IAWWESLLLL LAYAFYVFTM
610 620 630 640 650
KWNKHIEVWV KEQLSRRPVA KVMALEDLSK EDVAEAESTG EMPGEEGETA
660 670 680 690 700
GEGETEEKSG GETQPEGEGE TETQGKGEEC EDENEAEGKG DNEGEDEGEI
710 720 730 740 750
HAEDGEMKGN EGETESQELS AENHGEAKND EKGVEDGGGS DGGDSEEEEE
760 770 780 790 800
EEEEQEEEEE EEEQEEEEEE EEEEEEKGNE EPLSLDWPET RQKQAIYLFL
810 820 830 840 850
LPIVFPLWLT VPDVRRQESR KFFVFTFLGS IMWIAMFSYL MVWWAHQVGE
860 870 880 890 900
TIGISEEIMG LTILAAGTSI PDLITSVIVA RKGLGDMAVS SSVGSNIFDI
910 920 930 940 950
TVGLPVPWLL FSLINGLQPV PVSSNGLFCA IVLLFLMLLF VISSIASCKW
960 970 980
RMNKILGFTM FLLYFVFLII SVMLEDRIIS CPVSV
Length:985
Mass (Da):109,074
Last modified:June 28, 2011 - v1
Checksum:iD483D324929A0D50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011939 Genomic DNA No translation available.
AC027220 Genomic DNA No translation available.
RefSeqiXP_006720831.1, XM_006720768.3
UniGeneiHs.173092
Hs.617821

Genome annotation databases

EnsembliENST00000544319; ENSP00000445163; ENSG00000074621
GeneIDi9187
UCSCiuc059kks.1 human

Similar proteinsi

Entry informationi

Entry nameiF5H483_HUMAN
AccessioniPrimary (citable) accession number: F5H483
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: June 28, 2011
Last modified: March 28, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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