UniProtKB - F5H3U5 (F5H3U5_HUMAN)
Protein
Submitted name:
Acyl-CoA (8-3)-desaturase
Gene
FADS1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- lipid metabolic process Source: UniProtKB-KW
Keywordsi
Biological process | Lipid biosynthesisARBA annotation, Lipid metabolism |
Names & Taxonomyi
Protein namesi | Submitted name: Acyl-CoA (8-3)-desaturaseImported |
Gene namesi | Name:FADS1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3574, FADS1 |
VEuPathDBi | HostDB:ENSG00000149485.16 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 50 – 74 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 16 | Sequence analysisAdd BLAST | 16 | |
ChainiPRO_5003324758 | 17 – 192 | Sequence analysisAdd BLAST | 176 |
Proteomic databases
MaxQBi | F5H3U5 |
PeptideAtlasi | F5H3U5 |
PRIDEi | F5H3U5 |
ProteomicsDBi | 26378 |
Expressioni
Gene expression databases
Bgeei | ENSG00000149485, Expressed in mammalian vulva and 241 other tissues |
ExpressionAtlasi | F5H3U5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 165 | FA_desaturaseInterPro annotationAdd BLAST | 134 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00950000182990 |
Family and domain databases
InterProi | View protein in InterPro IPR005804, FA_desaturase_dom |
Pfami | View protein in Pfam PF00487, FA_desaturase, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All
F5H3U5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTFLCSCLLF VSVSSPVGPP ALLPLYFQWY IFYFVIQRKK WVDLAWMITF
60 70 80 90 100
YVRFFLTYVP LLGLKAFLGL FFIVRFLESN WFVWVTQMNH IPMHIDHDRN
110 120 130 140 150
MDWVSTQLQA TCNVHKSAFN DWFSGHLNFQ IEHHLFPTMP RHNYHKVAPL
160 170 180 190
VQSLCAKHGI EYQSKPLLSA FADIIHSLKE SGQLWLDAYL HQ
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO60427 | FADS1_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 FADSD5 | 444 | Annotation score: | ||
A0A0A0MR51 | A0A0A0MR51_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 hCG_40849 | 501 | Annotation score: | ||
H7C2V0 | H7C2V0_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 228 | Annotation score: | ||
F5H3P6 | F5H3P6_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 146 | Annotation score: | ||
F5GWE3 | F5GWE3_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 165 | Annotation score: | ||
F5GYH4 | F5GYH4_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 153 | Annotation score: | ||
F5H852 | F5H852_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 164 | Annotation score: | ||
H0YB97 | H0YB97_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 175 | Annotation score: | ||
F5H8G5 | F5H8G5_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 124 | Annotation score: | ||
C9J425 | C9J425_HUMAN | Acyl-CoA (8-3)-desaturase | FADS1 | 47 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP002380 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000536991; ENSP00000439097; ENSG00000149485 |
UCSCi | uc058cel.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP002380 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | F5H3U5 |
PeptideAtlasi | F5H3U5 |
PRIDEi | F5H3U5 |
ProteomicsDBi | 26378 |
Protocols and materials databases
Antibodypediai | 21596, 261 antibodies |
Genome annotation databases
Ensembli | ENST00000536991; ENSP00000439097; ENSG00000149485 |
UCSCi | uc058cel.1, human |
Organism-specific databases
HGNCi | HGNC:3574, FADS1 |
OpenTargetsi | ENSG00000149485 |
VEuPathDBi | HostDB:ENSG00000149485.16 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000182990 |
Miscellaneous databases
ChiTaRSi | FADS1, human |
Gene expression databases
Bgeei | ENSG00000149485, Expressed in mammalian vulva and 241 other tissues |
ExpressionAtlasi | F5H3U5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR005804, FA_desaturase_dom |
Pfami | View protein in Pfam PF00487, FA_desaturase, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F5H3U5_HUMAN | |
Accessioni | F5H3U5Primary (citable) accession number: F5H3U5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | February 10, 2021 | |
This is version 53 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |