UniProtKB - F5H2D5 (F5H2D5_HUMAN)
Protein
Submitted name:
Rap guanine nucleotide exchange factor-like 1
Gene
RAPGEFL1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
GO - Biological processi
- small GTPase mediated signal transduction Source: InterPro
Keywordsi
Molecular function | Guanine-nucleotide releasing factorPROSITE-ProRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Rap guanine nucleotide exchange factor-like 1Imported |
Gene namesi | Name:RAPGEFL1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000108352.11 |
HGNCi | HGNC:17428, RAPGEFL1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000108352, Expressed in skin of abdomen and 176 other tissues |
ExpressionAtlasi | F5H2D5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 267 – 503 | Ras-GEFInterPro annotationAdd BLAST | 237 |
Phylogenomic databases
GeneTreei | ENSGT00940000160144 |
Family and domain databases
CDDi | cd00155, RasGEF, 1 hit |
Gene3Di | 1.10.840.10, 1 hit |
InterProi | View protein in InterPro IPR008937, Ras-like_GEF IPR023578, Ras_GEF_dom_sf IPR001895, RASGEF_cat_dom IPR036964, RASGEF_cat_dom_sf IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR23113, PTHR23113, 1 hit |
Pfami | View protein in Pfam PF00617, RasGEF, 1 hit |
SMARTi | View protein in SMART SM00147, RasGEF, 1 hit |
SUPFAMi | SSF48366, SSF48366, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50009, RASGEF_CAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
F5H2D5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMLRPGYPLS QESFPIDILL DDIVLTHSLF LPTEKFLQEL HQYFVRAGGM
60 70 80 90 100
EGPEGLGRKQ ACLAMLLHFL DTYQGLLQEE EGAGHIIKDL YLLIMKDESL
110 120 130 140 150
YQGLREDTLR LHQLVETVEL KIPEENQPPS KQVKPLFRHF RRIDSCLQTR
160 170 180 190 200
VAFRGSDEIF CRVYMPDHSY VTIRSRLSAS VQDILGSVTE KLQYSEEPAG
210 220 230 240 250
REDSLILVAV SSSGEKVLLQ PTEDCVFTAL GINSHLFACT RDSYEALVPL
260 270 280 290 300
PEEIQVSPGD TEIHRVEPED VANHLTAFHW ELFRCVHELE FVDYVFHGER
310 320 330 340 350
GRRETANLEL LLQRCSEVTH WVATEVLLCE APGKRAQLLK KFIKIAALCK
360 370 380 390 400
QNQDLLSFYA VVMGLDNAAV SRLRLTWEKL PGKFKNLFRK FENLTDPCRN
410 420 430 440 450
HKSYREVISK MKPPVIPFVP LILKDLTFLH EGSKTLVDGL VNIEKLHSVA
460 470 480 490 500
EKVRTIRKYR SRPLCLDMEA SPNHLQTKAY VRQFQVIDNQ NLLFELSYKL
EANSQ
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9UHV5 | RPGFL_HUMAN | Rap guanine nucleotide exchange fac... | RAPGEFL1 | 662 | Annotation score: | ||
A0A087WVW6 | A0A087WVW6_HUMAN | Rap guanine nucleotide exchange fac... | RAPGEFL1 | 662 | Annotation score: | ||
F5GYJ3 | F5GYJ3_HUMAN | Rap guanine nucleotide exchange fac... | RAPGEFL1 | 149 | Annotation score: | ||
F5GXC6 | F5GXC6_HUMAN | Rap guanine nucleotide exchange fac... | RAPGEFL1 | 101 | Annotation score: | ||
F5H582 | F5H582_HUMAN | Rap guanine nucleotide exchange fac... | RAPGEFL1 | 62 | Annotation score: | ||
F5GY17 | F5GY17_HUMAN | Rap guanine nucleotide exchange fac... | RAPGEFL1 | 20 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC068669 Genomic DNA No translation available. KF459699 Genomic DNA No translation available. |
RefSeqi | NP_001290463.1, NM_001303534.1 |
Genome annotation databases
Ensembli | ENST00000544503; ENSP00000438631; ENSG00000108352 |
GeneIDi | 51195 |
UCSCi | uc060exm.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC068669 Genomic DNA No translation available. KF459699 Genomic DNA No translation available. |
RefSeqi | NP_001290463.1, NM_001303534.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | F5H2D5 |
PRIDEi | F5H2D5 |
ProteomicsDBi | 25937 |
Protocols and materials databases
Antibodypediai | 16447, 75 antibodies |
Genome annotation databases
Ensembli | ENST00000544503; ENSP00000438631; ENSG00000108352 |
GeneIDi | 51195 |
UCSCi | uc060exm.1, human |
Organism-specific databases
CTDi | 51195 |
EuPathDBi | HostDB:ENSG00000108352.11 |
HGNCi | HGNC:17428, RAPGEFL1 |
OpenTargetsi | ENSG00000108352 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160144 |
Miscellaneous databases
BioGRID-ORCSi | 51195, 5 hits in 842 CRISPR screens |
ChiTaRSi | RAPGEFL1, human |
GenomeRNAii | 51195 |
Gene expression databases
Bgeei | ENSG00000108352, Expressed in skin of abdomen and 176 other tissues |
ExpressionAtlasi | F5H2D5, baseline and differential |
Family and domain databases
CDDi | cd00155, RasGEF, 1 hit |
Gene3Di | 1.10.840.10, 1 hit |
InterProi | View protein in InterPro IPR008937, Ras-like_GEF IPR023578, Ras_GEF_dom_sf IPR001895, RASGEF_cat_dom IPR036964, RASGEF_cat_dom_sf IPR029071, Ubiquitin-like_domsf |
PANTHERi | PTHR23113, PTHR23113, 1 hit |
Pfami | View protein in Pfam PF00617, RasGEF, 1 hit |
SMARTi | View protein in SMART SM00147, RasGEF, 1 hit |
SUPFAMi | SSF48366, SSF48366, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS50009, RASGEF_CAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F5H2D5_HUMAN | |
Accessioni | F5H2D5Primary (citable) accession number: F5H2D5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | December 2, 2020 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |