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Protein

Peptidyl-prolyl cis-trans isomerase A-like 4D

Gene

PPIAL4D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Miscellaneous

It is one of six related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 1.Curated

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase A-like 4DCurated (EC:5.2.1.8)
Short name:
PPIase A-like 4D
Gene namesi
Name:PPIAL4DImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000256374.2
HGNCiHGNC:33998 PPIAL4D
neXtProtiNX_F5H284

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004209071 – 164Peptidyl-prolyl cis-trans isomerase A-like 4DAdd BLAST164

Proteomic databases

MaxQBiF5H284
PaxDbiF5H284
PRIDEiF5H284
ProteomicsDBi25892

PTM databases

iPTMnetiF5H284
PhosphoSitePlusiF5H284

Expressioni

Gene expression databases

BgeeiENSG00000256374

Organism-specific databases

HPAiHPA058345

Interactioni

Protein-protein interaction databases

IntActiF5H284, 1 interactor
STRINGi9606.ENSP00000439444

Structurei

3D structure databases

ProteinModelPortaliF5H284
SMRiF5H284
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 163PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST157

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0865 Eukaryota
COG0652 LUCA
GeneTreeiENSGT00760000119119
InParanoidiF5H284
KOiK12738
OrthoDBiEOG091G0BGL
PhylomeDBiF5H284
TreeFamiTF316719

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

F5H284-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNSVVFFEI TRDGKPLGRI SIKLFADKIP KTAENFRALS TGEKGFRYKG
60 70 80 90 100
SCFHRIIPGF MCQGGDFTRP NGTGDKSIYG EKFDDENLIR KHTGSGILSM
110 120 130 140 150
ANAGPNTNGS QFFICAAKTE WLDGKHVAFG KVKERVNIVE ATEHFGYRNS
160
KTSKKITIAD CGQF
Length:164
Mass (Da):18,167
Last modified:June 28, 2011 - v1
Checksum:i647DF57F1A6FC81E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX283067 Genomic DNA No translation available.
CCDSiCCDS59199.1
RefSeqiNP_001157733.1, NM_001164261.1
UniGeneiHs.730589

Genome annotation databases

EnsembliENST00000544708; ENSP00000439444; ENSG00000256374
GeneIDi645142
KEGGihsa:645142
UCSCiuc031usm.2 human

Similar proteinsi

Entry informationi

Entry nameiPAL4D_HUMAN
AccessioniPrimary (citable) accession number: F5H284
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: June 28, 2011
Last modified: July 18, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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