UniProtKB - F5H1T4 (F5H1T4_HUMAN)
Protein
Receptor protein-tyrosine kinase
Gene
ERBB2
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:2.7.10.1ARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Kinase, ReceptorARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ERBB2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3430, ERBB2 |
VEuPathDBi | HostDB:ENSG00000141736.13 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
MembranePTM / Processingi
Keywords - PTMi
GlycoproteinARBA annotation, PhosphoproteinARBA annotationProteomic databases
MaxQBi | F5H1T4 |
PeptideAtlasi | F5H1T4 |
PRIDEi | F5H1T4 |
ProteomicsDBi | 25755 |
Expressioni
Gene expression databases
Bgeei | ENSG00000141736, Expressed in esophagus mucosa and 226 other tissues |
ExpressionAtlasi | F5H1T4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 142 | Recep_L_domainInterPro annotationAdd BLAST | 121 | |
Domaini | 160 – 313 | Furin-likeInterPro annotationAdd BLAST | 154 | |
Domaini | 336 – 455 | Recep_L_domainInterPro annotationAdd BLAST | 120 | |
Domaini | 481 – 602 | GF_recep_IVInterPro annotationAdd BLAST | 122 |
Keywords - Domaini
Transmembrane, Transmembrane helixARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000158232 |
OrthoDBi | 81952at2759 |
Family and domain databases
CDDi | cd00064, FU, 3 hits |
Gene3Di | 3.80.20.20, 2 hits |
InterProi | View protein in InterPro IPR006211, Furin-like_Cys-rich_dom IPR006212, Furin_repeat IPR032778, GF_recep_IV IPR009030, Growth_fac_rcpt_cys_sf IPR000494, Rcpt_L-dom IPR036941, Rcpt_L-dom_sf |
Pfami | View protein in Pfam PF00757, Furin-like, 1 hit PF14843, GF_recep_IV, 1 hit PF01030, Recep_L_domain, 2 hits |
SMARTi | View protein in SMART SM00261, FU, 3 hits |
SUPFAMi | SSF57184, SSF57184, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
F5H1T4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLRLPASPE THLDMLRHLY QGCQVVQGNL ELTYLPTNAS LSFLQDIQEV
60 70 80 90 100
QGYVLIAHNQ VRQVPLQRLR IVRGTQLFED NYALAVLDNG DPLNNTTPVT
110 120 130 140 150
GASPGGLREL QLRSLTEILK GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA
160 170 180 190 200
LTLIDTNRSR ACHPCSPMCK GSRCWGESSE DCQSLTRTVC AGGCARCKGP
210 220 230 240 250
LPTDCCHEQC AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE
260 270 280 290 300
SMPNPEGRYT FGASCVTACP YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR
310 320 330 340 350
CEKCSKPCAR VCYGLGMEHL REVRAVTSAN IQEFAGCKKI FGSLAFLPES
360 370 380 390 400
FDGDPASNTA PLQPEQLQVF ETLEEITGYL YISAWPDSLP DLSVFQNLQV
410 420 430 440 450
IRGRILHNGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHH NTHLCFVHTV
460 470 480 490 500
PWDQLFRNPH QALLHTANRP EDECVGEGLA CHQLCARGHC WGPGPTQCVN
510 520 530 540 550
CSQFLRGQEC VEECRVLQGL PREYVNARHC LPCHPECQPQ NGSVTCFGPE
560 570 580 590 600
ADQCVACAHY KDPPFCVARC PSGVKPDLSY MPIWKFPDEE GACQPCPINC
THS
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP04626 | ERBB2_HUMAN | Receptor tyrosine-protein kinase er... | ERBB2 HER2, MLN19, NEU, NGL | 1,255 | Annotation score: | ||
J3QLU9 | J3QLU9_HUMAN | Receptor protein-tyrosine kinase | ERBB2 | 1,055 | Annotation score: | ||
B4DTR1 | B4DTR1_HUMAN | Receptor tyrosine-protein kinase er... | ERBB2 | 979 | Annotation score: | ||
J3KTI5 | J3KTI5_HUMAN | Receptor tyrosine-protein kinase er... | ERBB2 | 251 | Annotation score: | ||
J3QRJ7 | J3QRJ7_HUMAN | Receptor tyrosine-protein kinase er... | ERBB2 | 177 | Annotation score: | ||
J3KRI9 | J3KRI9_HUMAN | Receptor tyrosine-protein kinase er... | ERBB2 | 96 | Annotation score: | ||
J3QL83 | J3QL83_HUMAN | Receptor tyrosine-protein kinase er... | ERBB2 | 90 | Annotation score: | ||
J3QRX1 | J3QRX1_HUMAN | Receptor tyrosine-protein kinase er... | ERBB2 | 166 | Annotation score: | ||
J3QLV2 | J3QLV2_HUMAN | Receptor tyrosine-protein kinase er... | ERBB2 | 102 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC079199 Genomic DNA No translation available. AC087491 Genomic DNA No translation available. |
RefSeqi | NP_001276867.1, NM_001289938.1 |
Genome annotation databases
Ensembli | ENST00000578199; ENSP00000462808; ENSG00000141736 |
GeneIDi | 2064 |
UCSCi | uc002hsl.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC079199 Genomic DNA No translation available. AC087491 Genomic DNA No translation available. |
RefSeqi | NP_001276867.1, NM_001289938.1 |
3D structure databases
SMRi | F5H1T4 |
ModBasei | Search... |
Proteomic databases
MaxQBi | F5H1T4 |
PeptideAtlasi | F5H1T4 |
PRIDEi | F5H1T4 |
ProteomicsDBi | 25755 |
Protocols and materials databases
Antibodypediai | 740, 5598 antibodies |
Genome annotation databases
Ensembli | ENST00000578199; ENSP00000462808; ENSG00000141736 |
GeneIDi | 2064 |
UCSCi | uc002hsl.4, human |
Organism-specific databases
CTDi | 2064 |
HGNCi | HGNC:3430, ERBB2 |
OpenTargetsi | ENSG00000141736 |
VEuPathDBi | HostDB:ENSG00000141736.13 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158232 |
OrthoDBi | 81952at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2064, 72 hits in 905 CRISPR screens |
ChiTaRSi | ERBB2, human |
GenomeRNAii | 2064 |
Gene expression databases
Bgeei | ENSG00000141736, Expressed in esophagus mucosa and 226 other tissues |
ExpressionAtlasi | F5H1T4, baseline and differential |
Family and domain databases
CDDi | cd00064, FU, 3 hits |
Gene3Di | 3.80.20.20, 2 hits |
InterProi | View protein in InterPro IPR006211, Furin-like_Cys-rich_dom IPR006212, Furin_repeat IPR032778, GF_recep_IV IPR009030, Growth_fac_rcpt_cys_sf IPR000494, Rcpt_L-dom IPR036941, Rcpt_L-dom_sf |
Pfami | View protein in Pfam PF00757, Furin-like, 1 hit PF14843, GF_recep_IV, 1 hit PF01030, Recep_L_domain, 2 hits |
SMARTi | View protein in SMART SM00261, FU, 3 hits |
SUPFAMi | SSF57184, SSF57184, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F5H1T4_HUMAN | |
Accessioni | F5H1T4Primary (citable) accession number: F5H1T4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | February 10, 2021 | |
This is version 72 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |