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Protein
Submitted name:

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

Gene

GNB3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiF5H100

Names & Taxonomyi

Protein namesi
Submitted name:
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3Imported
Gene namesi
Name:GNB3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111664.10
HGNCiHGNC:4400 GNB3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000111664

PTM / Processingi

Proteomic databases

MaxQBiF5H100
PeptideAtlasiF5H100
PRIDEiF5H100

Expressioni

Gene expression databases

BgeeiENSG00000111664 Expressed in 146 organ(s), highest expression level in pituitary gland
ExpressionAtlasiF5H100 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliF5H100
SMRiF5H100
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 232WD_REPEATS_REGIONInterPro annotationAdd BLAST182
Repeati51 – 92WDPROSITE-ProRule annotationAdd BLAST42
Repeati139 – 179WDPROSITE-ProRule annotationAdd BLAST41
Repeati180 – 221WDPROSITE-ProRule annotationAdd BLAST42

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 31Sequence analysisAdd BLAST31

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, WD repeatPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0286 Eukaryota
ENOG410XQUX LUCA
GeneTreeiENSGT00760000119239

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001632 Gprotein_B
IPR016346 Guanine_nucleotide-bd_bsu
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19850 PTHR19850, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00319 GPROTEINB
PR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

F5H100-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEMEQLRQE AEQLKKQIAD ARKACADVTL AELVSGLEVV GRVQMRTRRT
60 70 80 90 100
LRGHLAKIYA MHWATDSKLL VSASQDGKLI VWDSYTTNKV HAIPLRSSWV
110 120 130 140 150
MTCAYAPSGN FVACGGLDNM CSIYNLKSRE GNVKVSRELS AHTGYLSCCR
160 170 180 190 200
FLDDNNIVTS SGDTTCALWD IETGQQKTVF VGHTGDCMSL AVSPDFNLFI
210 220 230
SGACDASAKL WDVREGTCRQ TFTGHESDIN AI
Length:232
Mass (Da):25,482
Last modified:September 18, 2013 - v2
Checksum:i88E16B5DB2B12B30
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P16520GBB3_HUMAN
Guanine nucleotide-binding protein ...
GNB3
340Annotation score:
E9PCP0E9PCP0_HUMAN
Guanine nucleotide-binding protein ...
GNB3
339Annotation score:
F5H8J8F5H8J8_HUMAN
Guanine nucleotide-binding protein ...
GNB3
232Annotation score:
F5H0S8F5H0S8_HUMAN
Guanine nucleotide-binding protein ...
GNB3
264Annotation score:
F5GZN8F5GZN8_HUMAN
Guanine nucleotide-binding protein ...
GNB3
36Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei232Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47924 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000541978; ENSP00000439753; ENSG00000111664
UCSCiuc058klt.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47924 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliF5H100
SMRiF5H100
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiF5H100
PeptideAtlasiF5H100
PRIDEiF5H100

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000541978; ENSP00000439753; ENSG00000111664
UCSCiuc058klt.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000111664.10
HGNCiHGNC:4400 GNB3
OpenTargetsiENSG00000111664
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0286 Eukaryota
ENOG410XQUX LUCA
GeneTreeiENSGT00760000119239

Enzyme and pathway databases

SignaLinkiF5H100

Miscellaneous databases

ChiTaRSiGNB3 human

Gene expression databases

BgeeiENSG00000111664 Expressed in 146 organ(s), highest expression level in pituitary gland
ExpressionAtlasiF5H100 baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001632 Gprotein_B
IPR016346 Guanine_nucleotide-bd_bsu
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PANTHERiPTHR19850 PTHR19850, 1 hit
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00319 GPROTEINB
PR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF5H100_HUMAN
AccessioniPrimary (citable) accession number: F5H100
Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: September 18, 2013
Last modified: September 12, 2018
This is version 52 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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