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Entry version 68 (07 Oct 2020)
Sequence version 2 (29 Oct 2014)
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Protein
Submitted name:

CUB and sushi domain-containing protein 1

Gene

CSMD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CUB and sushi domain-containing protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSMD1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000183117.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14026, CSMD1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3350 – 3371HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000183117

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi415 ↔ 442PROSITE-ProRule annotation
Disulfide bondi761 ↔ 788PROSITE-ProRule annotation
Disulfide bondi1139 ↔ 1166PROSITE-ProRule annotation
Disulfide bondi2510 ↔ 2537PROSITE-ProRule annotation
Disulfide bondi2568 ↔ 2595PROSITE-ProRule annotation
Disulfide bondi2626 ↔ 2653PROSITE-ProRule annotation
Disulfide bondi2689 ↔ 2716PROSITE-ProRule annotation
Disulfide bondi2747 ↔ 2774PROSITE-ProRule annotation
Disulfide bondi2808 ↔ 2835PROSITE-ProRule annotation
Disulfide bondi2867 ↔ 2894PROSITE-ProRule annotation
Disulfide bondi2985 ↔ 3012PROSITE-ProRule annotation
Disulfide bondi3043 ↔ 3070PROSITE-ProRule annotation
Disulfide bondi3105 ↔ 3132PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
F5GZ18

PRoteomics IDEntifications database

More...
PRIDEi
F5GZ18

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
24910

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183117, Expressed in primary visual cortex and 156 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
F5GZ18, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
F5GZ18, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 66SushiInterPro annotationAdd BLAST62
Domaini70 – 174CUBInterPro annotationAdd BLAST105
Domaini209 – 270SushiInterPro annotationAdd BLAST62
Domaini273 – 384CUBInterPro annotationAdd BLAST112
Domaini387 – 444SushiInterPro annotationAdd BLAST58
Domaini446 – 554CUBInterPro annotationAdd BLAST109
Domaini557 – 618SushiInterPro annotationAdd BLAST62
Domaini620 – 728CUBInterPro annotationAdd BLAST109
Domaini733 – 790SushiInterPro annotationAdd BLAST58
Domaini792 – 902CUBInterPro annotationAdd BLAST111
Domaini905 – 964SushiInterPro annotationAdd BLAST60
Domaini966 – 1074CUBInterPro annotationAdd BLAST109
Domaini1077 – 1137SushiInterPro annotationAdd BLAST61
Domaini1139 – 1248CUBInterPro annotationAdd BLAST110
Domaini1251 – 1311SushiInterPro annotationAdd BLAST61
Domaini1313 – 1421CUBInterPro annotationAdd BLAST109
Domaini1424 – 1485SushiInterPro annotationAdd BLAST62
Domaini1487 – 1595CUBInterPro annotationAdd BLAST109
Domaini1601 – 1662SushiInterPro annotationAdd BLAST62
Domaini1664 – 1772CUBInterPro annotationAdd BLAST109
Domaini1775 – 1834SushiInterPro annotationAdd BLAST60
Domaini1836 – 1944CUBInterPro annotationAdd BLAST109
Domaini1947 – 2006SushiInterPro annotationAdd BLAST60
Domaini2008 – 2119CUBInterPro annotationAdd BLAST112
Domaini2118 – 2179SushiInterPro annotationAdd BLAST62
Domaini2181 – 2292CUBInterPro annotationAdd BLAST112
Domaini2292 – 2354SushiInterPro annotationAdd BLAST63
Domaini2355 – 2416SushiInterPro annotationAdd BLAST62
Domaini2417 – 2481SushiInterPro annotationAdd BLAST65
Domaini2482 – 2539SushiInterPro annotationAdd BLAST58
Domaini2540 – 2597SushiInterPro annotationAdd BLAST58
Domaini2598 – 2655SushiInterPro annotationAdd BLAST58
Domaini2656 – 2718SushiInterPro annotationAdd BLAST63
Domaini2719 – 2776SushiInterPro annotationAdd BLAST58
Domaini2780 – 2837SushiInterPro annotationAdd BLAST58
Domaini2838 – 2896SushiInterPro annotationAdd BLAST59
Domaini2897 – 2956SushiInterPro annotationAdd BLAST60
Domaini2957 – 3014SushiInterPro annotationAdd BLAST58
Domaini3015 – 3072SushiInterPro annotationAdd BLAST58
Domaini3076 – 3134SushiInterPro annotationAdd BLAST59
Domaini3135 – 3194SushiInterPro annotationAdd BLAST60

Keywords - Domaini

SushiPROSITE-ProRule annotationARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155701

TreeFam database of animal gene trees

More...
TreeFami
TF316872

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 28 hits
cd00041, CUB, 13 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 13 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 13 hits
PF00084, Sushi, 28 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032, CCP, 28 hits
SM00042, CUB, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 13 hits
SSF57535, SSF57535, 28 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01180, CUB, 13 hits
PS50923, SUSHI, 28 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

F5GZ18-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VLPSHTCGNP GEILKGVLHG TRFNIGDKIR YSCLPGYILE GHAILTCIVS
60 70 80 90 100
PGNGASWDFP APFCRAEGAC GGTLRGTSSS ISSPHFPSEY ENNADCTWTI
110 120 130 140 150
LAEPGDTIAL VFTDFQLEEG YDFLEISGTE APSIWLTGMN LPSPVISSKN
160 170 180 190 200
WLRLHFTSDS NHRRKGFNAQ FQVKKAIELK SRGVKMLPSK DGSHKNSVLS
210 220 230 240 250
QGGVALVSDM CPDPGIPENG RRAGSDFRVG ANVQFSCEDN YVLQGSKSIT
260 270 280 290 300
CQRVTETLAA WSDHRPICRA RTCGSNLRGP SGVITSPNYP VQYEDNAHCV
310 320 330 340 350
WVITTTDPDK VIKLAFEEFE LERGYDTLTV GDAGKVGDTR SVLYVLTGSS
360 370 380 390 400
VPDLIVSMSN QMWLHLQSDD SIGSPGFKAV YQEIEKGGCG DPGIPAYGKR
410 420 430 440 450
TGSSFLHGDT LTFECPAAFE LVGERVITCQ QNNQWSGNKP SCVFSCFFNF
460 470 480 490 500
TASSGIILSP NYPEEYGNNM NCVWLIISEP GSRIHLIFND FDVEPQFDFL
510 520 530 540 550
AVKDDGISDI TVLGTFSGNE VPSQLASSGH IVRLEFQSDH STTGRGFNIT
560 570 580 590 600
YTTFGQNECH DPGIPINGRR FGDRFLLGSS VSFHCDDGFV KTQGSESITC
610 620 630 640 650
ILQDGNVVWS STVPRCEAPC GGHLTASSGV ILPPGWPGYY KDSLHCEWII
660 670 680 690 700
EAKPGHSIKI TFDRFQTEVN YDTLEVRDGP ASSSPLIGEY HGTQAPQFLI
710 720 730 740 750
STGNFMYLLF TTDNSRSSIG FLIHYESVTL ESDSCLDPGI PVNGHRHGGD
760 770 780 790 800
FGIRSTVTFS CDPGYTLSDD EPLVCERNHQ WNHALPSCDA LCGGYIQGKS
810 820 830 840 850
GTVLSPGFPD FYPNSLNCTW TIEVSHGKGV QMIFHTFHLE SSHDYLLITE
860 870 880 890 900
DGSFSEPVAR LTGSVLPHTI KAGLFGNFTA QLRFISDFSI SYEGFNITFS
910 920 930 940 950
EYDLEPCDDP GVPAFSRRIG FHFGVGDSLT FSCFLGYRLE GATKLTCLGG
960 970 980 990 1000
GRRVWSAPLP RCVAECGASV KGNEGTLLSP NFPSNYDNNH ECIYKIETEA
1010 1020 1030 1040 1050
GKGIHLRTRS FQLFEGDTLK VYDGKDSSSR PLGTFTKNEL LGLILNSTSN
1060 1070 1080 1090 1100
HLWLEFNTNG SDTDQGFQLT YTSFDLVKCE DPGIPNYGYR IRDEGHFTDT
1110 1120 1130 1140 1150
VVLYSCNPGY AMHGSNTLTC LSGDRRVWDK PLPSCIAECG GQIHAATSGR
1160 1170 1180 1190 1200
ILSPGYPAPY DNNLHCTWII EADPGKTISL HFIVFDTEMA HDILKVWDGP
1210 1220 1230 1240 1250
VDSDILLKEW SGSALPEDIH STFNSLTLQF DSDFFISKSG FSIQFSTSIA
1260 1270 1280 1290 1300
ATCNDPGMPQ NGTRYGDSRE AGDTVTFQCD PGYQLQGQAK ITCVQLNNRF
1310 1320 1330 1340 1350
FWQPDPPTCI AACGGNLTGP AGVILSPNYP QPYPPGKECD WRVKVNPDFV
1360 1370 1380 1390 1400
IALIFKSFNM EPSYDFLHIY EGEDSNSPLI GSYQGSQAPE RIESSGNSLF
1410 1420 1430 1440 1450
LAFRSDASVG LSGFAIEFKE KPREACFDPG NIMNGTRVGT DFKLGSTITY
1460 1470 1480 1490 1500
QCDSGYKILD PSSITCVIGA DGKPSWDQVL PSCNAPCGGQ YTGSEGVVLS
1510 1520 1530 1540 1550
PNYPHNYTAG QICLYSITVP KEFVVFGQFA YFQTALNDLA ELFDGTHAQA
1560 1570 1580 1590 1600
RLLSSLSGSH SGETLPLATS NQILLRFSAK SGASARGFHF VYQAVPRTSD
1610 1620 1630 1640 1650
TQCSSVPEPR YGRRIGSEFS AGSIVRFECN PGYLLQGSTA LHCQSVPNAL
1660 1670 1680 1690 1700
AQWNDTIPSC VVPCSGNFTQ RRGTILSPGY PEPYGNNLNC IWKIIVTEGS
1710 1720 1730 1740 1750
GIQIQVISFA TEQNWDSLEI HDGGDVTAPR LGSFSGTTVP ALLNSTSNQL
1760 1770 1780 1790 1800
YLHFQSDISV AAAGFHLEYK TVGLAACQEP ALPSNSIKIG DRYMVNDVLS
1810 1820 1830 1840 1850
FQCEPGYTLQ GRSHISCMPG TVRRWNYPSP LCIATCGGTL STLGGVILSP
1860 1870 1880 1890 1900
GFPGSYPNNL DCTWRISLPI GYGAHIQFLN FSTEANHDFL EIQNGPYHTS
1910 1920 1930 1940 1950
PMIGQFSGTD LPAALLSTTH ETLIHFYSDH SQNRQGFKLA YQAYELQNCP
1960 1970 1980 1990 2000
DPPPFQNGYM INSDYSVGQS VSFECYPGYI LIGHPVLTCQ HGINRNWNYP
2010 2020 2030 2040 2050
FPRCDAPCGY NVTSQNGTIY SPGFPDEYPI LKDCIWLITV PPGHGVYINF
2060 2070 2080 2090 2100
TLLQTEAVND YIAVWDGPDQ NSPQLGVFSG NTALETAYSS TNQVLLKFHS
2110 2120 2130 2140 2150
DFSNGGFFVL NFHAFQLKKC QPPPAVPQAE MLTEDDDFEI GDFVKYQCHP
2160 2170 2180 2190 2200
GYTLVGTDIL TCKLSSQLQF EGSLPTCEAQ CPANEVRTGS SGVILSPGYP
2210 2220 2230 2240 2250
GNYFNSQTCS WSIKVEPNYN ITIFVDTFQS EKQFDALEVF DGSSGQSPLL
2260 2270 2280 2290 2300
VVLSGNHTEQ SNFTSRSNQL YLRWSTDHAT SKKGFKIRYA APYCSLTHPL
2310 2320 2330 2340 2350
KNGGILNRTA GAVGSKVHYF CKPGYRMVGH SNATCRRNPL GMYQWDSLTP
2360 2370 2380 2390 2400
LCQAVSCGIP ESPGNGSFTG NEFTLDSKVV YECHEGFKLE SSQQATAVCQ
2410 2420 2430 2440 2450
EDGLWSNKGK PPTCKPVACP SIEAQLSEHV IWRLVSGSLN EYGAQVLLSC
2460 2470 2480 2490 2500
SPGYYLEGWR LLRCQANGTW NIGDERPSCR VISCGSLSFP PNGNKIGTLT
2510 2520 2530 2540 2550
VYGATAIFTC NTGYTLVGSH VRECLANGLW SGSETRCLAG HCGSPDPIVN
2560 2570 2580 2590 2600
GHISGDGFSY RDTVVYQCNP GFRLVGTSVR ICLQDHKWSG QTPVCVPITC
2610 2620 2630 2640 2650
GHPGNPAHGF TNGSEFNLND VVNFTCNTGY LLQGVSRAQC RSNGQWSSPL
2660 2670 2680 2690 2700
PTCRVVNCSD PGFVENAIRH GQQNFPESFE YGMSILYHCK KGFYLLGSSA
2710 2720 2730 2740 2750
LTCMANGLWD RSLPKCLAIS CGHPGVPANA VLTGELFTYG AVVHYSCRGS
2760 2770 2780 2790 2800
ESLIGNDTRV CQEDSHWSGA LPHCTGNNPG FCGDPGTPAH GSRLGDDFKT
2810 2820 2830 2840 2850
KSLLRFSCEM GHQLRGSPER TCLLNGSWSG LQPVCEAVSC GNPGTPTNGM
2860 2870 2880 2890 2900
IVSSDGILFS SSVIYACWEG YKTSGLMTRH CTANGTWTGT APDCTIISCG
2910 2920 2930 2940 2950
DPGTLANGIQ FGTDFTFNKT VSYQCNPGYV MEAVTSATIR CTKDGRWNPS
2960 2970 2980 2990 3000
KPVCKAVLCP QPPPVQNGTV EGSDFRWGSS ISYSCMDGYQ LSHSAILSCE
3010 3020 3030 3040 3050
GRGVWKGEIP QCLPVFCGDP GIPAEGRLSG KSFTYKSEVF FQCKSPFILV
3060 3070 3080 3090 3100
GSSRRVCQAD GTWSGIQPTC IDPAHNTCPD PGTPHFGIQN SSRGYEVGST
3110 3120 3130 3140 3150
VFFRCRKGYH IQGSTTRTCL ANLTWSGIQT ECIPHACRQP ETPAHADVRA
3160 3170 3180 3190 3200
IDLPTFGYTL VYTCHPGFFL AGGSEHRTCK ADMKWTGKSP VCKSKGVREV
3210 3220 3230 3240 3250
NETVTKTPVP SDVFFVNSLW KGYYEYLGKR QPATLTVDWF NATSSKVNAT
3260 3270 3280 3290 3300
FSEASPVELK LTGIYKKEEA HLLLKAFQIK GQADIFVSKF ENDNWGLDGY
3310 3320 3330 3340 3350
VSSGLERGGF TFQGDIHGKD FGKFKLERQD PLNPDQDSSS HYHGTSSGSV
3360 3370 3380 3390 3400
AAAILVPFFA LILSGFAFYL YKHRTRPKVQ YNGYAGHENS NGQASFENPM
3410 3420
YDTNLKPTEA KAVRFDTTLN TVCTVV
Length:3,426
Mass (Da):373,554
Last modified:October 29, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C4CDE6D4238AFD3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96PZ7CSMD1_HUMAN
CUB and sushi domain-containing pro...
CSMD1 KIAA1890, UNQ5952/PRO19863
3,564Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9C3F8W9C3_HUMAN
CUB and sushi domain-containing pro...
CSMD1
3,388Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIG2E5RIG2_HUMAN
CUB and sushi domain-containing pro...
CSMD1
3,565Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXU2H7BXU2_HUMAN
CUB and sushi domain-containing pro...
CSMD1
2,967Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC021523 Genomic DNA No translation available.
AC023296 Genomic DNA No translation available.
AC026991 Genomic DNA No translation available.
AC087692 Genomic DNA No translation available.
AC135324 Genomic DNA No translation available.
KF458665 Genomic DNA No translation available.
KF458666 Genomic DNA No translation available.
KF458667 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000537824; ENSP00000441462; ENSG00000183117

UCSC genome browser

More...
UCSCi
uc064jzl.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021523 Genomic DNA No translation available.
AC023296 Genomic DNA No translation available.
AC026991 Genomic DNA No translation available.
AC087692 Genomic DNA No translation available.
AC135324 Genomic DNA No translation available.
KF458665 Genomic DNA No translation available.
KF458666 Genomic DNA No translation available.
KF458667 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiF5GZ18
PRIDEiF5GZ18
ProteomicsDBi24910

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
52810, 77 antibodies

The DNASU plasmid repository

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DNASUi
64478

Genome annotation databases

EnsembliENST00000537824; ENSP00000441462; ENSG00000183117
UCSCiuc064jzl.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000183117.18
HGNCiHGNC:14026, CSMD1
OpenTargetsiENSG00000183117

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

GeneTreeiENSGT00940000155701
TreeFamiTF316872

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CSMD1, human

Gene expression databases

BgeeiENSG00000183117, Expressed in primary visual cortex and 156 other tissues
ExpressionAtlasiF5GZ18, baseline and differential
GenevisibleiF5GZ18, HS

Family and domain databases

CDDicd00033, CCP, 28 hits
cd00041, CUB, 13 hits
Gene3Di2.60.120.290, 13 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00431, CUB, 13 hits
PF00084, Sushi, 28 hits
SMARTiView protein in SMART
SM00032, CCP, 28 hits
SM00042, CUB, 13 hits
SUPFAMiSSF49854, SSF49854, 13 hits
SSF57535, SSF57535, 28 hits
PROSITEiView protein in PROSITE
PS01180, CUB, 13 hits
PS50923, SUSHI, 28 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF5GZ18_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F5GZ18
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 29, 2014
Last modified: October 7, 2020
This is version 68 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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