UniProtKB - F5GZ18 (F5GZ18_HUMAN)
Protein
Submitted name:
CUB and sushi domain-containing protein 1
Gene
CSMD1
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
Names & Taxonomyi
Protein namesi | Submitted name: CUB and sushi domain-containing protein 1Imported |
Gene namesi | Name:CSMD1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000183117.18 |
HGNCi | HGNC:14026, CSMD1 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 3350 – 3371 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 415 ↔ 442 | PROSITE-ProRule annotation | ||
Disulfide bondi | 761 ↔ 788 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1139 ↔ 1166 | PROSITE-ProRule annotation | ||
Disulfide bondi | 2510 ↔ 2537 | PROSITE-ProRule annotation | ||
Disulfide bondi | 2568 ↔ 2595 | PROSITE-ProRule annotation | ||
Disulfide bondi | 2626 ↔ 2653 | PROSITE-ProRule annotation | ||
Disulfide bondi | 2689 ↔ 2716 | PROSITE-ProRule annotation | ||
Disulfide bondi | 2747 ↔ 2774 | PROSITE-ProRule annotation | ||
Disulfide bondi | 2808 ↔ 2835 | PROSITE-ProRule annotation | ||
Disulfide bondi | 2867 ↔ 2894 | PROSITE-ProRule annotation | ||
Disulfide bondi | 2985 ↔ 3012 | PROSITE-ProRule annotation | ||
Disulfide bondi | 3043 ↔ 3070 | PROSITE-ProRule annotation | ||
Disulfide bondi | 3105 ↔ 3132 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationProteomic databases
PeptideAtlasi | F5GZ18 |
PRIDEi | F5GZ18 |
ProteomicsDBi | 24910 |
Expressioni
Gene expression databases
Bgeei | ENSG00000183117, Expressed in primary visual cortex and 156 other tissues |
ExpressionAtlasi | F5GZ18, baseline and differential |
Genevisiblei | F5GZ18, HS |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 66 | SushiInterPro annotationAdd BLAST | 62 | |
Domaini | 70 – 174 | CUBInterPro annotationAdd BLAST | 105 | |
Domaini | 209 – 270 | SushiInterPro annotationAdd BLAST | 62 | |
Domaini | 273 – 384 | CUBInterPro annotationAdd BLAST | 112 | |
Domaini | 387 – 444 | SushiInterPro annotationAdd BLAST | 58 | |
Domaini | 446 – 554 | CUBInterPro annotationAdd BLAST | 109 | |
Domaini | 557 – 618 | SushiInterPro annotationAdd BLAST | 62 | |
Domaini | 620 – 728 | CUBInterPro annotationAdd BLAST | 109 | |
Domaini | 733 – 790 | SushiInterPro annotationAdd BLAST | 58 | |
Domaini | 792 – 902 | CUBInterPro annotationAdd BLAST | 111 | |
Domaini | 905 – 964 | SushiInterPro annotationAdd BLAST | 60 | |
Domaini | 966 – 1074 | CUBInterPro annotationAdd BLAST | 109 | |
Domaini | 1077 – 1137 | SushiInterPro annotationAdd BLAST | 61 | |
Domaini | 1139 – 1248 | CUBInterPro annotationAdd BLAST | 110 | |
Domaini | 1251 – 1311 | SushiInterPro annotationAdd BLAST | 61 | |
Domaini | 1313 – 1421 | CUBInterPro annotationAdd BLAST | 109 | |
Domaini | 1424 – 1485 | SushiInterPro annotationAdd BLAST | 62 | |
Domaini | 1487 – 1595 | CUBInterPro annotationAdd BLAST | 109 | |
Domaini | 1601 – 1662 | SushiInterPro annotationAdd BLAST | 62 | |
Domaini | 1664 – 1772 | CUBInterPro annotationAdd BLAST | 109 | |
Domaini | 1775 – 1834 | SushiInterPro annotationAdd BLAST | 60 | |
Domaini | 1836 – 1944 | CUBInterPro annotationAdd BLAST | 109 | |
Domaini | 1947 – 2006 | SushiInterPro annotationAdd BLAST | 60 | |
Domaini | 2008 – 2119 | CUBInterPro annotationAdd BLAST | 112 | |
Domaini | 2118 – 2179 | SushiInterPro annotationAdd BLAST | 62 | |
Domaini | 2181 – 2292 | CUBInterPro annotationAdd BLAST | 112 | |
Domaini | 2292 – 2354 | SushiInterPro annotationAdd BLAST | 63 | |
Domaini | 2355 – 2416 | SushiInterPro annotationAdd BLAST | 62 | |
Domaini | 2417 – 2481 | SushiInterPro annotationAdd BLAST | 65 | |
Domaini | 2482 – 2539 | SushiInterPro annotationAdd BLAST | 58 | |
Domaini | 2540 – 2597 | SushiInterPro annotationAdd BLAST | 58 | |
Domaini | 2598 – 2655 | SushiInterPro annotationAdd BLAST | 58 | |
Domaini | 2656 – 2718 | SushiInterPro annotationAdd BLAST | 63 | |
Domaini | 2719 – 2776 | SushiInterPro annotationAdd BLAST | 58 | |
Domaini | 2780 – 2837 | SushiInterPro annotationAdd BLAST | 58 | |
Domaini | 2838 – 2896 | SushiInterPro annotationAdd BLAST | 59 | |
Domaini | 2897 – 2956 | SushiInterPro annotationAdd BLAST | 60 | |
Domaini | 2957 – 3014 | SushiInterPro annotationAdd BLAST | 58 | |
Domaini | 3015 – 3072 | SushiInterPro annotationAdd BLAST | 58 | |
Domaini | 3076 – 3134 | SushiInterPro annotationAdd BLAST | 59 | |
Domaini | 3135 – 3194 | SushiInterPro annotationAdd BLAST | 60 |
Keywords - Domaini
SushiPROSITE-ProRule annotationARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155701 |
TreeFami | TF316872 |
Family and domain databases
CDDi | cd00033, CCP, 28 hits cd00041, CUB, 13 hits |
Gene3Di | 2.60.120.290, 13 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR035914, Sperma_CUB_dom_sf IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00431, CUB, 13 hits PF00084, Sushi, 28 hits |
SMARTi | View protein in SMART SM00032, CCP, 28 hits SM00042, CUB, 13 hits |
SUPFAMi | SSF49854, SSF49854, 13 hits SSF57535, SSF57535, 28 hits |
PROSITEi | View protein in PROSITE PS01180, CUB, 13 hits PS50923, SUSHI, 28 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
F5GZ18-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
VLPSHTCGNP GEILKGVLHG TRFNIGDKIR YSCLPGYILE GHAILTCIVS
60 70 80 90 100
PGNGASWDFP APFCRAEGAC GGTLRGTSSS ISSPHFPSEY ENNADCTWTI
110 120 130 140 150
LAEPGDTIAL VFTDFQLEEG YDFLEISGTE APSIWLTGMN LPSPVISSKN
160 170 180 190 200
WLRLHFTSDS NHRRKGFNAQ FQVKKAIELK SRGVKMLPSK DGSHKNSVLS
210 220 230 240 250
QGGVALVSDM CPDPGIPENG RRAGSDFRVG ANVQFSCEDN YVLQGSKSIT
260 270 280 290 300
CQRVTETLAA WSDHRPICRA RTCGSNLRGP SGVITSPNYP VQYEDNAHCV
310 320 330 340 350
WVITTTDPDK VIKLAFEEFE LERGYDTLTV GDAGKVGDTR SVLYVLTGSS
360 370 380 390 400
VPDLIVSMSN QMWLHLQSDD SIGSPGFKAV YQEIEKGGCG DPGIPAYGKR
410 420 430 440 450
TGSSFLHGDT LTFECPAAFE LVGERVITCQ QNNQWSGNKP SCVFSCFFNF
460 470 480 490 500
TASSGIILSP NYPEEYGNNM NCVWLIISEP GSRIHLIFND FDVEPQFDFL
510 520 530 540 550
AVKDDGISDI TVLGTFSGNE VPSQLASSGH IVRLEFQSDH STTGRGFNIT
560 570 580 590 600
YTTFGQNECH DPGIPINGRR FGDRFLLGSS VSFHCDDGFV KTQGSESITC
610 620 630 640 650
ILQDGNVVWS STVPRCEAPC GGHLTASSGV ILPPGWPGYY KDSLHCEWII
660 670 680 690 700
EAKPGHSIKI TFDRFQTEVN YDTLEVRDGP ASSSPLIGEY HGTQAPQFLI
710 720 730 740 750
STGNFMYLLF TTDNSRSSIG FLIHYESVTL ESDSCLDPGI PVNGHRHGGD
760 770 780 790 800
FGIRSTVTFS CDPGYTLSDD EPLVCERNHQ WNHALPSCDA LCGGYIQGKS
810 820 830 840 850
GTVLSPGFPD FYPNSLNCTW TIEVSHGKGV QMIFHTFHLE SSHDYLLITE
860 870 880 890 900
DGSFSEPVAR LTGSVLPHTI KAGLFGNFTA QLRFISDFSI SYEGFNITFS
910 920 930 940 950
EYDLEPCDDP GVPAFSRRIG FHFGVGDSLT FSCFLGYRLE GATKLTCLGG
960 970 980 990 1000
GRRVWSAPLP RCVAECGASV KGNEGTLLSP NFPSNYDNNH ECIYKIETEA
1010 1020 1030 1040 1050
GKGIHLRTRS FQLFEGDTLK VYDGKDSSSR PLGTFTKNEL LGLILNSTSN
1060 1070 1080 1090 1100
HLWLEFNTNG SDTDQGFQLT YTSFDLVKCE DPGIPNYGYR IRDEGHFTDT
1110 1120 1130 1140 1150
VVLYSCNPGY AMHGSNTLTC LSGDRRVWDK PLPSCIAECG GQIHAATSGR
1160 1170 1180 1190 1200
ILSPGYPAPY DNNLHCTWII EADPGKTISL HFIVFDTEMA HDILKVWDGP
1210 1220 1230 1240 1250
VDSDILLKEW SGSALPEDIH STFNSLTLQF DSDFFISKSG FSIQFSTSIA
1260 1270 1280 1290 1300
ATCNDPGMPQ NGTRYGDSRE AGDTVTFQCD PGYQLQGQAK ITCVQLNNRF
1310 1320 1330 1340 1350
FWQPDPPTCI AACGGNLTGP AGVILSPNYP QPYPPGKECD WRVKVNPDFV
1360 1370 1380 1390 1400
IALIFKSFNM EPSYDFLHIY EGEDSNSPLI GSYQGSQAPE RIESSGNSLF
1410 1420 1430 1440 1450
LAFRSDASVG LSGFAIEFKE KPREACFDPG NIMNGTRVGT DFKLGSTITY
1460 1470 1480 1490 1500
QCDSGYKILD PSSITCVIGA DGKPSWDQVL PSCNAPCGGQ YTGSEGVVLS
1510 1520 1530 1540 1550
PNYPHNYTAG QICLYSITVP KEFVVFGQFA YFQTALNDLA ELFDGTHAQA
1560 1570 1580 1590 1600
RLLSSLSGSH SGETLPLATS NQILLRFSAK SGASARGFHF VYQAVPRTSD
1610 1620 1630 1640 1650
TQCSSVPEPR YGRRIGSEFS AGSIVRFECN PGYLLQGSTA LHCQSVPNAL
1660 1670 1680 1690 1700
AQWNDTIPSC VVPCSGNFTQ RRGTILSPGY PEPYGNNLNC IWKIIVTEGS
1710 1720 1730 1740 1750
GIQIQVISFA TEQNWDSLEI HDGGDVTAPR LGSFSGTTVP ALLNSTSNQL
1760 1770 1780 1790 1800
YLHFQSDISV AAAGFHLEYK TVGLAACQEP ALPSNSIKIG DRYMVNDVLS
1810 1820 1830 1840 1850
FQCEPGYTLQ GRSHISCMPG TVRRWNYPSP LCIATCGGTL STLGGVILSP
1860 1870 1880 1890 1900
GFPGSYPNNL DCTWRISLPI GYGAHIQFLN FSTEANHDFL EIQNGPYHTS
1910 1920 1930 1940 1950
PMIGQFSGTD LPAALLSTTH ETLIHFYSDH SQNRQGFKLA YQAYELQNCP
1960 1970 1980 1990 2000
DPPPFQNGYM INSDYSVGQS VSFECYPGYI LIGHPVLTCQ HGINRNWNYP
2010 2020 2030 2040 2050
FPRCDAPCGY NVTSQNGTIY SPGFPDEYPI LKDCIWLITV PPGHGVYINF
2060 2070 2080 2090 2100
TLLQTEAVND YIAVWDGPDQ NSPQLGVFSG NTALETAYSS TNQVLLKFHS
2110 2120 2130 2140 2150
DFSNGGFFVL NFHAFQLKKC QPPPAVPQAE MLTEDDDFEI GDFVKYQCHP
2160 2170 2180 2190 2200
GYTLVGTDIL TCKLSSQLQF EGSLPTCEAQ CPANEVRTGS SGVILSPGYP
2210 2220 2230 2240 2250
GNYFNSQTCS WSIKVEPNYN ITIFVDTFQS EKQFDALEVF DGSSGQSPLL
2260 2270 2280 2290 2300
VVLSGNHTEQ SNFTSRSNQL YLRWSTDHAT SKKGFKIRYA APYCSLTHPL
2310 2320 2330 2340 2350
KNGGILNRTA GAVGSKVHYF CKPGYRMVGH SNATCRRNPL GMYQWDSLTP
2360 2370 2380 2390 2400
LCQAVSCGIP ESPGNGSFTG NEFTLDSKVV YECHEGFKLE SSQQATAVCQ
2410 2420 2430 2440 2450
EDGLWSNKGK PPTCKPVACP SIEAQLSEHV IWRLVSGSLN EYGAQVLLSC
2460 2470 2480 2490 2500
SPGYYLEGWR LLRCQANGTW NIGDERPSCR VISCGSLSFP PNGNKIGTLT
2510 2520 2530 2540 2550
VYGATAIFTC NTGYTLVGSH VRECLANGLW SGSETRCLAG HCGSPDPIVN
2560 2570 2580 2590 2600
GHISGDGFSY RDTVVYQCNP GFRLVGTSVR ICLQDHKWSG QTPVCVPITC
2610 2620 2630 2640 2650
GHPGNPAHGF TNGSEFNLND VVNFTCNTGY LLQGVSRAQC RSNGQWSSPL
2660 2670 2680 2690 2700
PTCRVVNCSD PGFVENAIRH GQQNFPESFE YGMSILYHCK KGFYLLGSSA
2710 2720 2730 2740 2750
LTCMANGLWD RSLPKCLAIS CGHPGVPANA VLTGELFTYG AVVHYSCRGS
2760 2770 2780 2790 2800
ESLIGNDTRV CQEDSHWSGA LPHCTGNNPG FCGDPGTPAH GSRLGDDFKT
2810 2820 2830 2840 2850
KSLLRFSCEM GHQLRGSPER TCLLNGSWSG LQPVCEAVSC GNPGTPTNGM
2860 2870 2880 2890 2900
IVSSDGILFS SSVIYACWEG YKTSGLMTRH CTANGTWTGT APDCTIISCG
2910 2920 2930 2940 2950
DPGTLANGIQ FGTDFTFNKT VSYQCNPGYV MEAVTSATIR CTKDGRWNPS
2960 2970 2980 2990 3000
KPVCKAVLCP QPPPVQNGTV EGSDFRWGSS ISYSCMDGYQ LSHSAILSCE
3010 3020 3030 3040 3050
GRGVWKGEIP QCLPVFCGDP GIPAEGRLSG KSFTYKSEVF FQCKSPFILV
3060 3070 3080 3090 3100
GSSRRVCQAD GTWSGIQPTC IDPAHNTCPD PGTPHFGIQN SSRGYEVGST
3110 3120 3130 3140 3150
VFFRCRKGYH IQGSTTRTCL ANLTWSGIQT ECIPHACRQP ETPAHADVRA
3160 3170 3180 3190 3200
IDLPTFGYTL VYTCHPGFFL AGGSEHRTCK ADMKWTGKSP VCKSKGVREV
3210 3220 3230 3240 3250
NETVTKTPVP SDVFFVNSLW KGYYEYLGKR QPATLTVDWF NATSSKVNAT
3260 3270 3280 3290 3300
FSEASPVELK LTGIYKKEEA HLLLKAFQIK GQADIFVSKF ENDNWGLDGY
3310 3320 3330 3340 3350
VSSGLERGGF TFQGDIHGKD FGKFKLERQD PLNPDQDSSS HYHGTSSGSV
3360 3370 3380 3390 3400
AAAILVPFFA LILSGFAFYL YKHRTRPKVQ YNGYAGHENS NGQASFENPM
3410 3420
YDTNLKPTEA KAVRFDTTLN TVCTVV
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ96PZ7 | CSMD1_HUMAN | CUB and sushi domain-containing pro... | CSMD1 KIAA1890, UNQ5952/PRO19863 | 3,564 | Annotation score: | ||
F8W9C3 | F8W9C3_HUMAN | CUB and sushi domain-containing pro... | CSMD1 | 3,388 | Annotation score: | ||
E5RIG2 | E5RIG2_HUMAN | CUB and sushi domain-containing pro... | CSMD1 | 3,565 | Annotation score: | ||
H7BXU2 | H7BXU2_HUMAN | CUB and sushi domain-containing pro... | CSMD1 | 2,967 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021523 Genomic DNA No translation available. AC023296 Genomic DNA No translation available. AC026991 Genomic DNA No translation available. AC087692 Genomic DNA No translation available. AC135324 Genomic DNA No translation available. KF458665 Genomic DNA No translation available. KF458666 Genomic DNA No translation available. KF458667 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000537824; ENSP00000441462; ENSG00000183117 |
UCSCi | uc064jzl.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC021523 Genomic DNA No translation available. AC023296 Genomic DNA No translation available. AC026991 Genomic DNA No translation available. AC087692 Genomic DNA No translation available. AC135324 Genomic DNA No translation available. KF458665 Genomic DNA No translation available. KF458666 Genomic DNA No translation available. KF458667 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | F5GZ18 |
PRIDEi | F5GZ18 |
ProteomicsDBi | 24910 |
Protocols and materials databases
Antibodypediai | 52810, 78 antibodies |
DNASUi | 64478 |
Genome annotation databases
Ensembli | ENST00000537824; ENSP00000441462; ENSG00000183117 |
UCSCi | uc064jzl.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000183117.18 |
HGNCi | HGNC:14026, CSMD1 |
OpenTargetsi | ENSG00000183117 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155701 |
TreeFami | TF316872 |
Miscellaneous databases
ChiTaRSi | CSMD1, human |
Gene expression databases
Bgeei | ENSG00000183117, Expressed in primary visual cortex and 156 other tissues |
ExpressionAtlasi | F5GZ18, baseline and differential |
Genevisiblei | F5GZ18, HS |
Family and domain databases
CDDi | cd00033, CCP, 28 hits cd00041, CUB, 13 hits |
Gene3Di | 2.60.120.290, 13 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR035914, Sperma_CUB_dom_sf IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
Pfami | View protein in Pfam PF00431, CUB, 13 hits PF00084, Sushi, 28 hits |
SMARTi | View protein in SMART SM00032, CCP, 28 hits SM00042, CUB, 13 hits |
SUPFAMi | SSF49854, SSF49854, 13 hits SSF57535, SSF57535, 28 hits |
PROSITEi | View protein in PROSITE PS01180, CUB, 13 hits PS50923, SUSHI, 28 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F5GZ18_HUMAN | |
Accessioni | F5GZ18Primary (citable) accession number: F5GZ18 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | October 29, 2014 | |
Last modified: | December 2, 2020 | |
This is version 69 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |