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UniProtKB - F5GZ18 (F5GZ18_HUMAN)

Entry version 68 (07 Oct 2020)
Sequence version 2 (29 Oct 2014)
Previous versions | rss
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Protein
Submitted name:

CUB and sushi domain-containing protein 1

Gene

CSMD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CUB and sushi domain-containing protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CSMD1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000183117.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:14026, CSMD1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3350 – 3371HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000183117

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi415 ↔ 442PROSITE-ProRule annotation
Disulfide bondi761 ↔ 788PROSITE-ProRule annotation
Disulfide bondi1139 ↔ 1166PROSITE-ProRule annotation
Disulfide bondi2510 ↔ 2537PROSITE-ProRule annotation
Disulfide bondi2568 ↔ 2595PROSITE-ProRule annotation
Disulfide bondi2626 ↔ 2653PROSITE-ProRule annotation
Disulfide bondi2689 ↔ 2716PROSITE-ProRule annotation
Disulfide bondi2747 ↔ 2774PROSITE-ProRule annotation
Disulfide bondi2808 ↔ 2835PROSITE-ProRule annotation
Disulfide bondi2867 ↔ 2894PROSITE-ProRule annotation
Disulfide bondi2985 ↔ 3012PROSITE-ProRule annotation
Disulfide bondi3043 ↔ 3070PROSITE-ProRule annotation
Disulfide bondi3105 ↔ 3132PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		F5GZ18

PRoteomics IDEntifications database

More...PRIDEi		F5GZ18

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		24910

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000183117, Expressed in primary visual cortex and 156 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		F5GZ18, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		F5GZ18, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 66SushiInterPro annotationAdd BLAST62
Domaini70 – 174CUBInterPro annotationAdd BLAST105
Domaini209 – 270SushiInterPro annotationAdd BLAST62
Domaini273 – 384CUBInterPro annotationAdd BLAST112
Domaini387 – 444SushiInterPro annotationAdd BLAST58
Domaini446 – 554CUBInterPro annotationAdd BLAST109
Domaini557 – 618SushiInterPro annotationAdd BLAST62
Domaini620 – 728CUBInterPro annotationAdd BLAST109
Domaini733 – 790SushiInterPro annotationAdd BLAST58
Domaini792 – 902CUBInterPro annotationAdd BLAST111
Domaini905 – 964SushiInterPro annotationAdd BLAST60
Domaini966 – 1074CUBInterPro annotationAdd BLAST109
Domaini1077 – 1137SushiInterPro annotationAdd BLAST61
Domaini1139 – 1248CUBInterPro annotationAdd BLAST110
Domaini1251 – 1311SushiInterPro annotationAdd BLAST61
Domaini1313 – 1421CUBInterPro annotationAdd BLAST109
Domaini1424 – 1485SushiInterPro annotationAdd BLAST62
Domaini1487 – 1595CUBInterPro annotationAdd BLAST109
Domaini1601 – 1662SushiInterPro annotationAdd BLAST62
Domaini1664 – 1772CUBInterPro annotationAdd BLAST109
Domaini1775 – 1834SushiInterPro annotationAdd BLAST60
Domaini1836 – 1944CUBInterPro annotationAdd BLAST109
Domaini1947 – 2006SushiInterPro annotationAdd BLAST60
Domaini2008 – 2119CUBInterPro annotationAdd BLAST112
Domaini2118 – 2179SushiInterPro annotationAdd BLAST62
Domaini2181 – 2292CUBInterPro annotationAdd BLAST112
Domaini2292 – 2354SushiInterPro annotationAdd BLAST63
Domaini2355 – 2416SushiInterPro annotationAdd BLAST62
Domaini2417 – 2481SushiInterPro annotationAdd BLAST65
Domaini2482 – 2539SushiInterPro annotationAdd BLAST58
Domaini2540 – 2597SushiInterPro annotationAdd BLAST58
Domaini2598 – 2655SushiInterPro annotationAdd BLAST58
Domaini2656 – 2718SushiInterPro annotationAdd BLAST63
Domaini2719 – 2776SushiInterPro annotationAdd BLAST58
Domaini2780 – 2837SushiInterPro annotationAdd BLAST58
Domaini2838 – 2896SushiInterPro annotationAdd BLAST59
Domaini2897 – 2956SushiInterPro annotationAdd BLAST60
Domaini2957 – 3014SushiInterPro annotationAdd BLAST58
Domaini3015 – 3072SushiInterPro annotationAdd BLAST58
Domaini3076 – 3134SushiInterPro annotationAdd BLAST59
Domaini3135 – 3194SushiInterPro annotationAdd BLAST60

Keywords - Domaini

SushiPROSITE-ProRule annotationARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155701

TreeFam database of animal gene trees

More...TreeFami		TF316872

Family and domain databases

Conserved Domains Database

More...CDDi		cd00033, CCP, 28 hits
cd00041, CUB, 13 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.290, 13 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00431, CUB, 13 hits
PF00084, Sushi, 28 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032, CCP, 28 hits
SM00042, CUB, 13 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49854, SSF49854, 13 hits
SSF57535, SSF57535, 28 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01180, CUB, 13 hits
PS50923, SUSHI, 28 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

F5GZ18-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VLPSHTCGNP GEILKGVLHG TRFNIGDKIR YSCLPGYILE GHAILTCIVS 
        60         70         80         90        100
PGNGASWDFP APFCRAEGAC GGTLRGTSSS ISSPHFPSEY ENNADCTWTI 
       110        120        130        140        150
LAEPGDTIAL VFTDFQLEEG YDFLEISGTE APSIWLTGMN LPSPVISSKN 
       160        170        180        190        200
WLRLHFTSDS NHRRKGFNAQ FQVKKAIELK SRGVKMLPSK DGSHKNSVLS 
       210        220        230        240        250
QGGVALVSDM CPDPGIPENG RRAGSDFRVG ANVQFSCEDN YVLQGSKSIT 
       260        270        280        290        300
CQRVTETLAA WSDHRPICRA RTCGSNLRGP SGVITSPNYP VQYEDNAHCV 
       310        320        330        340        350
WVITTTDPDK VIKLAFEEFE LERGYDTLTV GDAGKVGDTR SVLYVLTGSS 
       360        370        380        390        400
VPDLIVSMSN QMWLHLQSDD SIGSPGFKAV YQEIEKGGCG DPGIPAYGKR 
       410        420        430        440        450
TGSSFLHGDT LTFECPAAFE LVGERVITCQ QNNQWSGNKP SCVFSCFFNF 
       460        470        480        490        500
TASSGIILSP NYPEEYGNNM NCVWLIISEP GSRIHLIFND FDVEPQFDFL 
       510        520        530        540        550
AVKDDGISDI TVLGTFSGNE VPSQLASSGH IVRLEFQSDH STTGRGFNIT 
       560        570        580        590        600
YTTFGQNECH DPGIPINGRR FGDRFLLGSS VSFHCDDGFV KTQGSESITC 
       610        620        630        640        650
ILQDGNVVWS STVPRCEAPC GGHLTASSGV ILPPGWPGYY KDSLHCEWII 
       660        670        680        690        700
EAKPGHSIKI TFDRFQTEVN YDTLEVRDGP ASSSPLIGEY HGTQAPQFLI 
       710        720        730        740        750
STGNFMYLLF TTDNSRSSIG FLIHYESVTL ESDSCLDPGI PVNGHRHGGD 
       760        770        780        790        800
FGIRSTVTFS CDPGYTLSDD EPLVCERNHQ WNHALPSCDA LCGGYIQGKS 
       810        820        830        840        850
GTVLSPGFPD FYPNSLNCTW TIEVSHGKGV QMIFHTFHLE SSHDYLLITE 
       860        870        880        890        900
DGSFSEPVAR LTGSVLPHTI KAGLFGNFTA QLRFISDFSI SYEGFNITFS 
       910        920        930        940        950
EYDLEPCDDP GVPAFSRRIG FHFGVGDSLT FSCFLGYRLE GATKLTCLGG 
       960        970        980        990       1000
GRRVWSAPLP RCVAECGASV KGNEGTLLSP NFPSNYDNNH ECIYKIETEA 
      1010       1020       1030       1040       1050
GKGIHLRTRS FQLFEGDTLK VYDGKDSSSR PLGTFTKNEL LGLILNSTSN 
      1060       1070       1080       1090       1100
HLWLEFNTNG SDTDQGFQLT YTSFDLVKCE DPGIPNYGYR IRDEGHFTDT 
      1110       1120       1130       1140       1150
VVLYSCNPGY AMHGSNTLTC LSGDRRVWDK PLPSCIAECG GQIHAATSGR 
      1160       1170       1180       1190       1200
ILSPGYPAPY DNNLHCTWII EADPGKTISL HFIVFDTEMA HDILKVWDGP 
      1210       1220       1230       1240       1250
VDSDILLKEW SGSALPEDIH STFNSLTLQF DSDFFISKSG FSIQFSTSIA 
      1260       1270       1280       1290       1300
ATCNDPGMPQ NGTRYGDSRE AGDTVTFQCD PGYQLQGQAK ITCVQLNNRF 
      1310       1320       1330       1340       1350
FWQPDPPTCI AACGGNLTGP AGVILSPNYP QPYPPGKECD WRVKVNPDFV 
      1360       1370       1380       1390       1400
IALIFKSFNM EPSYDFLHIY EGEDSNSPLI GSYQGSQAPE RIESSGNSLF 
      1410       1420       1430       1440       1450
LAFRSDASVG LSGFAIEFKE KPREACFDPG NIMNGTRVGT DFKLGSTITY 
      1460       1470       1480       1490       1500
QCDSGYKILD PSSITCVIGA DGKPSWDQVL PSCNAPCGGQ YTGSEGVVLS 
      1510       1520       1530       1540       1550
PNYPHNYTAG QICLYSITVP KEFVVFGQFA YFQTALNDLA ELFDGTHAQA 
      1560       1570       1580       1590       1600
RLLSSLSGSH SGETLPLATS NQILLRFSAK SGASARGFHF VYQAVPRTSD 
      1610       1620       1630       1640       1650
TQCSSVPEPR YGRRIGSEFS AGSIVRFECN PGYLLQGSTA LHCQSVPNAL 
      1660       1670       1680       1690       1700
AQWNDTIPSC VVPCSGNFTQ RRGTILSPGY PEPYGNNLNC IWKIIVTEGS 
      1710       1720       1730       1740       1750
GIQIQVISFA TEQNWDSLEI HDGGDVTAPR LGSFSGTTVP ALLNSTSNQL 
      1760       1770       1780       1790       1800
YLHFQSDISV AAAGFHLEYK TVGLAACQEP ALPSNSIKIG DRYMVNDVLS 
      1810       1820       1830       1840       1850
FQCEPGYTLQ GRSHISCMPG TVRRWNYPSP LCIATCGGTL STLGGVILSP 
      1860       1870       1880       1890       1900
GFPGSYPNNL DCTWRISLPI GYGAHIQFLN FSTEANHDFL EIQNGPYHTS 
      1910       1920       1930       1940       1950
PMIGQFSGTD LPAALLSTTH ETLIHFYSDH SQNRQGFKLA YQAYELQNCP 
      1960       1970       1980       1990       2000
DPPPFQNGYM INSDYSVGQS VSFECYPGYI LIGHPVLTCQ HGINRNWNYP 
      2010       2020       2030       2040       2050
FPRCDAPCGY NVTSQNGTIY SPGFPDEYPI LKDCIWLITV PPGHGVYINF 
      2060       2070       2080       2090       2100
TLLQTEAVND YIAVWDGPDQ NSPQLGVFSG NTALETAYSS TNQVLLKFHS 
      2110       2120       2130       2140       2150
DFSNGGFFVL NFHAFQLKKC QPPPAVPQAE MLTEDDDFEI GDFVKYQCHP 
      2160       2170       2180       2190       2200
GYTLVGTDIL TCKLSSQLQF EGSLPTCEAQ CPANEVRTGS SGVILSPGYP 
      2210       2220       2230       2240       2250
GNYFNSQTCS WSIKVEPNYN ITIFVDTFQS EKQFDALEVF DGSSGQSPLL 
      2260       2270       2280       2290       2300
VVLSGNHTEQ SNFTSRSNQL YLRWSTDHAT SKKGFKIRYA APYCSLTHPL 
      2310       2320       2330       2340       2350
KNGGILNRTA GAVGSKVHYF CKPGYRMVGH SNATCRRNPL GMYQWDSLTP 
      2360       2370       2380       2390       2400
LCQAVSCGIP ESPGNGSFTG NEFTLDSKVV YECHEGFKLE SSQQATAVCQ 
      2410       2420       2430       2440       2450
EDGLWSNKGK PPTCKPVACP SIEAQLSEHV IWRLVSGSLN EYGAQVLLSC 
      2460       2470       2480       2490       2500
SPGYYLEGWR LLRCQANGTW NIGDERPSCR VISCGSLSFP PNGNKIGTLT 
      2510       2520       2530       2540       2550
VYGATAIFTC NTGYTLVGSH VRECLANGLW SGSETRCLAG HCGSPDPIVN 
      2560       2570       2580       2590       2600
GHISGDGFSY RDTVVYQCNP GFRLVGTSVR ICLQDHKWSG QTPVCVPITC 
      2610       2620       2630       2640       2650
GHPGNPAHGF TNGSEFNLND VVNFTCNTGY LLQGVSRAQC RSNGQWSSPL 
      2660       2670       2680       2690       2700
PTCRVVNCSD PGFVENAIRH GQQNFPESFE YGMSILYHCK KGFYLLGSSA 
      2710       2720       2730       2740       2750
LTCMANGLWD RSLPKCLAIS CGHPGVPANA VLTGELFTYG AVVHYSCRGS 
      2760       2770       2780       2790       2800
ESLIGNDTRV CQEDSHWSGA LPHCTGNNPG FCGDPGTPAH GSRLGDDFKT 
      2810       2820       2830       2840       2850
KSLLRFSCEM GHQLRGSPER TCLLNGSWSG LQPVCEAVSC GNPGTPTNGM 
      2860       2870       2880       2890       2900
IVSSDGILFS SSVIYACWEG YKTSGLMTRH CTANGTWTGT APDCTIISCG 
      2910       2920       2930       2940       2950
DPGTLANGIQ FGTDFTFNKT VSYQCNPGYV MEAVTSATIR CTKDGRWNPS 
      2960       2970       2980       2990       3000
KPVCKAVLCP QPPPVQNGTV EGSDFRWGSS ISYSCMDGYQ LSHSAILSCE 
      3010       3020       3030       3040       3050
GRGVWKGEIP QCLPVFCGDP GIPAEGRLSG KSFTYKSEVF FQCKSPFILV 
      3060       3070       3080       3090       3100
GSSRRVCQAD GTWSGIQPTC IDPAHNTCPD PGTPHFGIQN SSRGYEVGST 
      3110       3120       3130       3140       3150
VFFRCRKGYH IQGSTTRTCL ANLTWSGIQT ECIPHACRQP ETPAHADVRA 
      3160       3170       3180       3190       3200
IDLPTFGYTL VYTCHPGFFL AGGSEHRTCK ADMKWTGKSP VCKSKGVREV 
      3210       3220       3230       3240       3250
NETVTKTPVP SDVFFVNSLW KGYYEYLGKR QPATLTVDWF NATSSKVNAT 
      3260       3270       3280       3290       3300
FSEASPVELK LTGIYKKEEA HLLLKAFQIK GQADIFVSKF ENDNWGLDGY 
      3310       3320       3330       3340       3350
VSSGLERGGF TFQGDIHGKD FGKFKLERQD PLNPDQDSSS HYHGTSSGSV 
      3360       3370       3380       3390       3400
AAAILVPFFA LILSGFAFYL YKHRTRPKVQ YNGYAGHENS NGQASFENPM 
      3410       3420 
YDTNLKPTEA KAVRFDTTLN TVCTVV
Length:3,426
Mass (Da):373,554
Last modified:October 29, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C4CDE6D4238AFD3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q96PZ7CSMD1_HUMAN
CUB and sushi domain-containing pro...
CSMD1 KIAA1890, UNQ5952/PRO19863
3,564Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9C3F8W9C3_HUMAN
CUB and sushi domain-containing pro...
CSMD1
3,388Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIG2E5RIG2_HUMAN
CUB and sushi domain-containing pro...
CSMD1
3,565Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXU2H7BXU2_HUMAN
CUB and sushi domain-containing pro...
CSMD1
2,967Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC021523 Genomic DNA No translation available.
AC023296 Genomic DNA No translation available.
AC026991 Genomic DNA No translation available.
AC087692 Genomic DNA No translation available.
AC135324 Genomic DNA No translation available.
KF458665 Genomic DNA No translation available.
KF458666 Genomic DNA No translation available.
KF458667 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000537824; ENSP00000441462; ENSG00000183117

UCSC genome browser

More...UCSCi		uc064jzl.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC021523 Genomic DNA No translation available.
AC023296 Genomic DNA No translation available.
AC026991 Genomic DNA No translation available.
AC087692 Genomic DNA No translation available.
AC135324 Genomic DNA No translation available.
KF458665 Genomic DNA No translation available.
KF458666 Genomic DNA No translation available.
KF458667 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PeptideAtlasiF5GZ18
PRIDEiF5GZ18
ProteomicsDBi24910

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		52810, 77 antibodies

The DNASU plasmid repository

More...DNASUi		64478

Genome annotation databases

EnsembliENST00000537824; ENSP00000441462; ENSG00000183117
UCSCiuc064jzl.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000183117.18
HGNCiHGNC:14026, CSMD1
OpenTargetsiENSG00000183117

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000155701
TreeFamiTF316872

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CSMD1, human

Gene expression databases

BgeeiENSG00000183117, Expressed in primary visual cortex and 156 other tissues
ExpressionAtlasiF5GZ18, baseline and differential
GenevisibleiF5GZ18, HS

Family and domain databases

CDDicd00033, CCP, 28 hits
cd00041, CUB, 13 hits
Gene3Di2.60.120.290, 13 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR035914, Sperma_CUB_dom_sf
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00431, CUB, 13 hits
PF00084, Sushi, 28 hits
SMARTiView protein in SMART
SM00032, CCP, 28 hits
SM00042, CUB, 13 hits
SUPFAMiSSF49854, SSF49854, 13 hits
SSF57535, SSF57535, 28 hits
PROSITEiView protein in PROSITE
PS01180, CUB, 13 hits
PS50923, SUSHI, 28 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF5GZ18_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: F5GZ18
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 28, 2011
Last sequence update: October 29, 2014
Last modified: October 7, 2020
This is version 68 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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