UniProtKB - F5GYA2 (F5GYA2_HUMAN)
Protein
Uracil-DNA glycosylase
Gene
UNG
Organism
Homo sapiens (Human)
Status
Functioni
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation
Catalytic activityi
- Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation EC:3.2.2.27
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 145 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- uracil DNA N-glycosylase activity Source: UniProtKB-UniRule
GO - Biological processi
- base-excision repair Source: UniProtKB-UniRule
Keywordsi
Molecular function | HydrolaseUniRule annotationARBA annotation |
Biological process | DNA damage, DNA repairUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:UNGImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000076248.10 |
HGNCi | HGNC:12572, UNG |
Expressioni
Gene expression databases
Bgeei | ENSG00000076248, Expressed in secondary oocyte and 241 other tissues |
ExpressionAtlasi | F5GYA2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 130 – 249 | UDGInterPro annotationAdd BLAST | 120 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 40 – 59 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotationARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00390000003405 |
Family and domain databases
CDDi | cd10027, UDG_F1, 1 hit |
Gene3Di | 3.40.470.10, 1 hit |
InterProi | View protein in InterPro IPR002043, UDG_fam1 IPR018085, Ura-DNA_Glyclase_AS IPR005122, Uracil-DNA_glycosylase-like IPR036895, Uracil-DNA_glycosylase-like_sf |
PANTHERi | PTHR11264, PTHR11264, 1 hit |
Pfami | View protein in Pfam PF03167, UDG, 1 hit |
SMARTi | View protein in SMART SM00986, UDG, 1 hit |
SUPFAMi | SSF52141, SSF52141, 1 hit |
TIGRFAMsi | TIGR00628, ung, 1 hit |
PROSITEi | View protein in PROSITE PS00130, U_DNA_GLYCOSYLASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
F5GYA2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGVFCLGPWG LGRKLRTPGK GPLQLLSRLC GDHLQAIPAK KAPAGQEEPG
60 70 80 90 100
TPPSSPLSAE QLDRIQRNKA AALLRLAARN VPVGFGESWK KHLSGEFGKP
110 120 130 140 150
YFIKLMGFVA EERKHYTVYP PPHQVFTWTQ MCDIKDVKVV ILGQDPYHGP
160 170 180 190 200
NQAHGLCFSV QRPVPPPPSL ENIYKELSTD IEDFVHPGHG DLSGWAKQGV
210 220 230 240 250
LLLNAVLTVR AHQANSHKER GWEQFTDAVV SWLNQNSNGL VFLLWGSYAQ
KKGSAIDR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP13051 | UNG_HUMAN | Uracil-DNA glycosylase | UNG DGU, UNG1, UNG15 | 313 | Annotation score: | ||
Q68DM5 | Q68DM5_HUMAN | Uracil-DNA glycosylase | UNG DKFZp781L1143 | 141 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007637 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000539287; ENSP00000440784; ENSG00000076248 |
UCSCi | uc058sxn.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007637 Genomic DNA No translation available. |
3D structure databases
SMRi | F5GYA2 |
ModBasei | Search... |
Proteomic databases
MaxQBi | F5GYA2 |
PeptideAtlasi | F5GYA2 |
ProteomicsDBi | 24673 |
Genome annotation databases
Ensembli | ENST00000539287; ENSP00000440784; ENSG00000076248 |
UCSCi | uc058sxn.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000076248.10 |
HGNCi | HGNC:12572, UNG |
OpenTargetsi | ENSG00000076248 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000003405 |
Miscellaneous databases
ChiTaRSi | UNG, human |
Gene expression databases
Bgeei | ENSG00000076248, Expressed in secondary oocyte and 241 other tissues |
ExpressionAtlasi | F5GYA2, baseline and differential |
Family and domain databases
CDDi | cd10027, UDG_F1, 1 hit |
Gene3Di | 3.40.470.10, 1 hit |
InterProi | View protein in InterPro IPR002043, UDG_fam1 IPR018085, Ura-DNA_Glyclase_AS IPR005122, Uracil-DNA_glycosylase-like IPR036895, Uracil-DNA_glycosylase-like_sf |
PANTHERi | PTHR11264, PTHR11264, 1 hit |
Pfami | View protein in Pfam PF03167, UDG, 1 hit |
SMARTi | View protein in SMART SM00986, UDG, 1 hit |
SUPFAMi | SSF52141, SSF52141, 1 hit |
TIGRFAMsi | TIGR00628, ung, 1 hit |
PROSITEi | View protein in PROSITE PS00130, U_DNA_GLYCOSYLASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F5GYA2_HUMAN | |
Accessioni | F5GYA2Primary (citable) accession number: F5GYA2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | October 7, 2020 | |
This is version 64 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |