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UniProtKB - F5GXL4 (F5GXL4_HUMAN)
Protein
Submitted name:
Pepsin A-3
Gene
PGA3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- aspartic-type endopeptidase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Aspartyl proteaseUniRule annotation, Hydrolase, Protease |
Names & Taxonomyi
Protein namesi | Submitted name: Pepsin A-3Submitted name: Pepsin A-4 |
Gene namesi | Name:PGA3 Synonyms:PGA4 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8885, PGA3 HGNC:8886, PGA4 |
VEuPathDBi | HostDB:ENSG00000229183 HostDB:ENSG00000229859 |
PTM / Processingi
Keywords - PTMi
Disulfide bondARBA annotation, ZymogenARBA annotationProteomic databases
ProteomicsDBi | 24458 |
Expressioni
Gene expression databases
Bgeei | ENSG00000229183, Expressed in fundus of stomach and 101 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 231 | Peptidase A1InterPro annotationAdd BLAST | 231 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 22 – 61 | DisorderedSequence analysisAdd BLAST | 40 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000155036 |
HOGENOMi | CLU_013253_6_1_1 |
Family and domain databases
Gene3Di | 2.40.70.10, 1 hit |
InterProi | View protein in InterPro IPR001461, Aspartic_peptidase_A1 IPR001969, Aspartic_peptidase_AS IPR033121, PEPTIDASE_A1 IPR021109, Peptidase_aspartic_dom_sf |
PANTHERi | PTHR47966, PTHR47966, 1 hit |
Pfami | View protein in Pfam PF00026, Asp, 1 hit |
PRINTSi | PR00792, PEPSIN |
SUPFAMi | SSF50630, SSF50630, 1 hit |
PROSITEi | View protein in PROSITE PS00141, ASP_PROTEASE, 1 hit PS51767, PEPTIDASE_A1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
F5GXL4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSGNNSDSA HCIGTGLRGK ETTLVTPQDS PRKCPIKGSP EEATADGHTN
60 70 80 90 100
GRTKKFMSSP LTFHSDDQSG SVVIFGGIDS SYYTGSLNWV PVTVEGYWQI
110 120 130 140 150
TVDSITMNGE AIACAEGCQA IVDTGTSLLT GPTSPIANIQ SDIGASENSD
160 170 180 190 200
GDMVVSCSAI SSLPDIVFTI NGVQYPVPPS AYILQSEGSC ISGFQGMNLP
210 220 230
TESGELWILG DVFIRQYFTV FDRANNQVGL APVA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP0DJD7 | PEPA4_HUMAN | Pepsin A-4 | PGA4 | 388 | Annotation score: | ||
F5H0H6 | F5H0H6_HUMAN | Pepsin A-3 | PGA4 PGA3 | 128 | Annotation score: | ||
F5H842 | F5H842_HUMAN | Pepsin A-3 | PGA3 | 265 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000437 Genomic DNA No translation available. AP003037 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000537932.5; ENSP00000442757.1; ENSG00000229183.10 ENST00000543125.5; ENSP00000440177.1; ENSG00000229859.10 |
UCSCi | uc058bxx.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AP000437 Genomic DNA No translation available. AP003037 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 24458 |
Protocols and materials databases
Antibodypediai | 28068, 203 antibodies from 19 providers 28082, 138 antibodies from 21 providers |
Genome annotation databases
Ensembli | ENST00000537932.5; ENSP00000442757.1; ENSG00000229183.10 ENST00000543125.5; ENSP00000440177.1; ENSG00000229859.10 |
UCSCi | uc058bxx.1, human |
Organism-specific databases
HGNCi | HGNC:8885, PGA3 HGNC:8886, PGA4 |
OpenTargetsi | ENSG00000229183 ENSG00000229859 |
VEuPathDBi | HostDB:ENSG00000229183 HostDB:ENSG00000229859 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155036 |
HOGENOMi | CLU_013253_6_1_1 |
Miscellaneous databases
ChiTaRSi | PGA3, human |
Gene expression databases
Bgeei | ENSG00000229183, Expressed in fundus of stomach and 101 other tissues |
Family and domain databases
Gene3Di | 2.40.70.10, 1 hit |
InterProi | View protein in InterPro IPR001461, Aspartic_peptidase_A1 IPR001969, Aspartic_peptidase_AS IPR033121, PEPTIDASE_A1 IPR021109, Peptidase_aspartic_dom_sf |
PANTHERi | PTHR47966, PTHR47966, 1 hit |
Pfami | View protein in Pfam PF00026, Asp, 1 hit |
PRINTSi | PR00792, PEPSIN |
SUPFAMi | SSF50630, SSF50630, 1 hit |
PROSITEi | View protein in PROSITE PS00141, ASP_PROTEASE, 1 hit PS51767, PEPTIDASE_A1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | F5GXL4_HUMAN | |
Accessioni | F5GXL4Primary (citable) accession number: F5GXL4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | June 28, 2011 | |
Last modified: | May 25, 2022 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |