UniProtKB - F5GXF9 (F5GXF9_HUMAN)
Protein
Submitted name:
AF4/FMR2 family member 1
Gene
AFF1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: AF4/FMR2 family member 1Imported |
Gene namesi | Name:AFF1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7135, AFF1 |
VEuPathDBi | HostDB:ENSG00000172493.20 |
Subcellular locationi
Nucleus
- nucleus Source: UniProtKB-KW
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000172493, Expressed in placenta and 259 other tissues |
ExpressionAtlasi | F5GXF9, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 948 – 1182 | AF-4_CInterPro annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 45 | DisorderedSequence analysisAdd BLAST | 45 | |
Regioni | 73 – 314 | DisorderedSequence analysisAdd BLAST | 242 | |
Regioni | 366 – 956 | DisorderedSequence analysisAdd BLAST | 591 | |
Regioni | 1091 – 1119 | DisorderedSequence analysisAdd BLAST | 29 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 12 – 37 | PolyampholyteSequence analysisAdd BLAST | 26 | |
Compositional biasi | 99 – 135 | PolarSequence analysisAdd BLAST | 37 | |
Compositional biasi | 168 – 191 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 213 – 241 | PolarSequence analysisAdd BLAST | 29 | |
Compositional biasi | 371 – 426 | PolarSequence analysisAdd BLAST | 56 | |
Compositional biasi | 459 – 486 | PolarSequence analysisAdd BLAST | 28 | |
Compositional biasi | 585 – 605 | PolarSequence analysisAdd BLAST | 21 | |
Compositional biasi | 710 – 728 | PolarSequence analysisAdd BLAST | 19 | |
Compositional biasi | 781 – 833 | PolyampholyteSequence analysisAdd BLAST | 53 | |
Compositional biasi | 834 – 879 | PolarSequence analysisAdd BLAST | 46 | |
Compositional biasi | 911 – 927 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 928 – 943 | PolarSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the AF4 family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00950000182974 |
OrthoDBi | 558558at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR007797, AF4/FMR2 IPR043640, AF4/FMR2_CHD IPR043639, AF4_int |
PANTHERi | PTHR10528, PTHR10528, 1 hit |
Pfami | View protein in Pfam PF18876, AF-4_C, 1 hit PF18875, AF4_int, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
F5GXF9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAQSSLYND DRNLLRIREK ERRNQEAHQE KEAFPEKIPL FGEPYKTAKG
60 70 80 90 100
DELSSRIQNM LGNYEEVKEF LSTKSHTHRL DASENRLGKP KYPLIPDKGS
110 120 130 140 150
SIPSSSFHTS VHHQSIHTPA SGPLSVGNIS HNPKMAQPRT EPMPSLHAKS
160 170 180 190 200
CGPPDSQHLT QDRLGQEGFG SSHHKKGDRR ADGDHCASVT DSAPERELSP
210 220 230 240 250
LISLPSPVPP LSPIHSNQQT LPRTQGSSKV HGSSNNSKGY CPAKSPKDLA
260 270 280 290 300
VKVHDKETPQ DSLVAPAQPP SQTFPPPSLP SKSVAMQQKP TAYVRPMDGQ
310 320 330 340 350
DQAPSESPEL KPLPEDYRQQ TFEKTDLKVP AKAKLTKLKM PSQSVEQTYS
360 370 380 390 400
NEVHCVEEIL KEMTHSWPPP LTAIHTPSTA EPSKFPFPTK DSQHVSSVTQ
410 420 430 440 450
NQKQYDTSSK THSNSQQGTS SMLEDDLQLS DSEDSDSEQT PEKPPSSSAP
460 470 480 490 500
PSAPQSLPEP VASAHSSSAE SESTSDSDSS SDSESESSSS DSEENEPLET
510 520 530 540 550
PAPEPEPPTT NKWQLDNWLT KVSQPAAPPE GPRSTEPPRR HPESKGSSDS
560 570 580 590 600
ATSQEHSESK DPPPKSSSKA PRAPPEAPHP GKRSCQKSPA QQEPPQRQTV
610 620 630 640 650
GTKQPKKPVK ASARAGSRTS LQGEREPGLL PYGSRDQTSK DKPKVKTKGR
660 670 680 690 700
PRAAASNEPK PAVPPSSEKK KHKSSLPAPS KALSGPEPAK DNVEDRTPEH
710 720 730 740 750
FALVPLTESQ GPPHSGSGSR TSGCRQAVVV QEDSRKDRLP LPLRDTKLLS
760 770 780 790 800
PLRDTPPPQS LMVKITLDLL SRIPQPPGKG SRQRKAEDKQ PPAGKKHSSE
810 820 830 840 850
KRSSDSSSKL AKKRKGEAER DCDNKKIRLE KEIKSQSSSS SSSHKESSKT
860 870 880 890 900
KPSRPSSQSS KKEMLPPPPV SSSSQKPAKP ALKRSRREAD TCGQDPPKVP
910 920 930 940 950
AVPRATTDSS IPKQRRVEGK GSRSSSEHKG SSGDTANPFP VPSLPNGNSK
960 970 980 990 1000
PGKPQVKFDK QQADLHMREA KKMKQKAELM TDRVGKAFKY LEAVLSFIEC
1010 1020 1030 1040 1050
GIATESESQS SKSAYSVYSE TVDLIKFIMS LKSFSDATAP TQEKIFAVLC
1060 1070 1080 1090 1100
MRCQSILNMA MFRCKKDIAI KYSRTLNKHF ESSSKVAQAP SPCIARSTGT
1110 1120 1130 1140 1150
PSPLSPMPSP ASSVGSQSSA GSVGSSGVAA TISTPVTIQN MTSSYVTITS
1160 1170 1180 1190 1200
HVLTAFDLWE QAEALTRKNK EFFARLSQMC APWPSTAVWW TWCTIHDRVF
SSYKN
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP51825 | AFF1_HUMAN | AF4/FMR2 family member 1 | AFF1 AF4, FEL, MLLT2, PBM1 | 1,210 | Annotation score: | ||
A0A669KBI3 | A0A669KBI3_HUMAN | AF4/FMR2 family member 1 | AFF1 | 1,075 | Annotation score: | ||
E7ETI4 | E7ETI4_HUMAN | AF4/FMR2 family member 1 | AFF1 | 406 | Annotation score: | ||
H0Y9S4 | H0Y9S4_HUMAN | AF4/FMR2 family member 1 | AFF1 | 194 | Annotation score: | ||
D6RAU0 | D6RAU0_HUMAN | AF4/FMR2 family member 1 | AFF1 | 137 | Annotation score: | ||
D6RIZ5 | D6RIZ5_HUMAN | AF4/FMR2 family member 1 | AFF1 | 52 | Annotation score: | ||
E7EMC5 | E7EMC5_HUMAN | AF4/FMR2 family member 1 | AFF1 | 417 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092658 Genomic DNA No translation available. AC093779 Genomic DNA No translation available. AC093827 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000544085; ENSP00000440843; ENSG00000172493 |
UCSCi | uc062yab.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092658 Genomic DNA No translation available. AC093779 Genomic DNA No translation available. AC093827 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | F5GXF9 |
PRIDEi | F5GXF9 |
ProteomicsDBi | 24412 |
Protocols and materials databases
Antibodypediai | 25387, 249 antibodies |
Genome annotation databases
Ensembli | ENST00000544085; ENSP00000440843; ENSG00000172493 |
UCSCi | uc062yab.1, human |
Organism-specific databases
HGNCi | HGNC:7135, AFF1 |
OpenTargetsi | ENSG00000172493 |
VEuPathDBi | HostDB:ENSG00000172493.20 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000182974 |
OrthoDBi | 558558at2759 |
Miscellaneous databases
ChiTaRSi | AFF1, human |
Gene expression databases
Bgeei | ENSG00000172493, Expressed in placenta and 259 other tissues |
ExpressionAtlasi | F5GXF9, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR007797, AF4/FMR2 IPR043640, AF4/FMR2_CHD IPR043639, AF4_int |
PANTHERi | PTHR10528, PTHR10528, 1 hit |
Pfami | View protein in Pfam PF18876, AF-4_C, 1 hit PF18875, AF4_int, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F5GXF9_HUMAN | |
Accessioni | F5GXF9Primary (citable) accession number: F5GXF9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 28, 2011 |
Last sequence update: | October 29, 2014 | |
Last modified: | February 10, 2021 | |
This is version 64 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |